Adult Disseminated Primary Papular Xanthoma Treated With Doxycycline

Bastida, Jesús

doi:10.1001/archderm.143.5.667

Cited by 8 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For MCRH, because of the frequent failure of cytotoxic and anti-TNF-α drugs and the risk of associated malignant conditions, an interesting complete remission was obtained with anakinra [18]. Similarly, besides local treatment for isolated and/or accessible lesions in XD, several treatment strategies showed disappointing results (or were successful in isolated cases), including lipid-lowering agents, prednisone, interferon-α, immunosuppressants and chemotherapies (table 1) [20,21,22,23,24,25,26,27,28,29,30,31]. The proposal of anakinra therefore appears adequate in our XD patient, by analogy with its harmless and successful results in ECD and MCRH, on the basis of histological and biological evidence for the leading role of IL-1 cytokines in these last two NLH [3,18].…”

Section: Discussionmentioning

confidence: 99%

Cerebral and Cutaneous Involvements of Xanthoma Disseminatum Successfully Treated with an Interleukin-1 Receptor Antagonist: A Case Report and Minireview

Campero¹,

Campero

Guerrero

et al. 2016

Dermatology

View full text Add to dashboard Cite

A young male presented with panhypopituitarism (including diabetes insipidus) and temporal lobe epilepsy. A histology specimen of cutaneous papules was diagnostic of non-Langerhans histiocytosis. The diagnosis of xanthoma granulomata was considered based on the clinical and brain MRI findings. Brain lesions significantly worsened over time despite radiotherapy until anakinra induced a complete clinical and radiological remission of all active lesions. Although a single case, the outcome of this patient with xanthoma disseminatum treated with an interleukin-1 receptor antagonist opens and strengthens new and recent physiopathogenic and treatment perspectives for the otherwise difficult-to-treat non-Langerhans cell histiocytosis. Similar results with anakinra have been observed in patients with Erdheim-Chester disease and in multicentric reticulohistiocytosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Cerebral and Cutaneous Involvements of Xanthoma Disseminatum Successfully Treated with an Interleukin-1 Receptor Antagonist: A Case Report and Minireview

Campero¹,

Campero

Guerrero

et al. 2016

Dermatology

View full text Add to dashboard Cite

show abstract

“…Though there is a case report of an adult PX being resolved satisfactorily with doxycycline. [11] Juvenile xanthogranuloma is characterised by presentation in infancy, single or few lesions, involvement of mucous membranes, presence of telengiectasia and involvement of visceral organs such as lung, liver, spleen, testes, pericardium, gastrointestinal tract, kidney, deeper soft tissues and central nervous system. Histopathology (HPE) reveals mixed cellular dermal infiltrate comprising of histiocytes, lymphocytes, eosinophils, occasional neutrophils, plasma cells and extending into the subcutaneous fat.…”

Section: Discussionmentioning

confidence: 99%

Papular xanthoma in a child: Report of a rare entity

Jadhav¹,

Choudhary²,

Ahar³

et al. 2015

Indian J Paediatr Dermatol

View full text Add to dashboard Cite

family members including his three younger siblings had similar lesions. The child was otherwise normal except for complaints of occasional low-grade fever. On examination, numerous close set xanthomatous lesions chiefly comprising of flat-topped papules of various sizes, the largest being 7 mm in diameter were seen on face, trunk, back, upper arms, axillae and groin creases. Eyelids were spared, so was the scalp. Few lesions showed central umbilication. The papules were discrete with no tendency to coalesce. There was a line of demarcation just above the buttocks, below which the lesions were conspicuously absent (except a few in popliteal fossae). The papules were firm on palpation and were nontender. Hair, nails, oral and genital mucosa were normal. General examination revealed no abnormality. There was no lymphadenopathy. A differential diagnosis of benign cephalic histiocytosis (BCH) and xanthoma disseminatum were considered. All hematological investigations including the serum lipid profile were normal. Ultrasonography abdomen-pelvis and chest X-ray revealed no abnormalities. Histopathological examination of one of the papules showed a thin epidermis, dense histiocytic infiltrate in the upper and mid dermis with numerous foam cells and a moderate numbers of foamy multinucleate Touton giant cells [ Figure 2a]. The lower epidermis showed mild infiltrate with hyalinization of collagen. Immunohistochemistry showed positive staining for CD68 and was negative for CD1a [ Figure 2b]. ABSTRACTPapular xanthoma (PX) is a form of Non-Langerhan's cell histiocytosis, which is rare and primarily affects adults. Rarely cases have been reported in children as well though the presentation in both the age groups vary considerably. We present a case of PX in a 4½-year-old male child who presented with multiple asymptomatic skin-colored papular lesions on the body.

show abstract

“…In general, lesions presenting in childhood tended to be self-limited, some healing with anetodermalike scars, while adult-onset papular xanthoma more commonly persisted. Of the 53 patients reported with papular xanthoma, 1,[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] 35 were part of four comprehensive cases series. 6,7,9,13 Of the three series reporting follow-up, 6,13 18 patients were tracked with a median follow-up of 28 months (mean 41.3 months), of which two patients experienced recurrent or persistent lesions.…”

Section: Papular Xanthoma Is a Rare Entity First Described In 1980 Bymentioning

confidence: 99%

Multiple papular xanthomas mimicking juvenile xanthogranulomas in an infant: A case report and review of the literature

et al. 2022

View full text Add to dashboard Cite

Adult Disseminated Primary Papular Xanthoma Treated With Doxycycline

Cited by 8 publications

References 6 publications

Cerebral and Cutaneous Involvements of Xanthoma Disseminatum Successfully Treated with an Interleukin-1 Receptor Antagonist: A Case Report and Minireview

Cerebral and Cutaneous Involvements of Xanthoma Disseminatum Successfully Treated with an Interleukin-1 Receptor Antagonist: A Case Report and Minireview

Papular xanthoma in a child: Report of a rare entity

Multiple papular xanthomas mimicking juvenile xanthogranulomas in an infant: A case report and review of the literature

Contact Info

Product

Resources

About