Adult BMI change and risk of Breast Cancer: National Health and Nutrition Examination Survey (NHANES) 2005–2010

Abstract

Objective Breast cancer is the second leading cause of cancer mortality among women in the developed world. This study assessed the association between occurrence of breast cancer and Body Mass Index (BMI) change from age 25 to age closest to breast cancer diagnosis while exploring the modifying effects of demographic variables. Methods The National Health and Nutrition Examination Survey data were used. Women included were ≥50 years, not pregnant and without a diagnosis of any cancer but breast. The total sample included 2,895 women (172 with breast cancer and 2,723 controls with no breast cancer diagnosis). Multivariate logistic regression was used to estimate the OR and 95% CI’s and interaction evaluated by including an interaction term in the model. Results Women whose BMI increased from normal or overweight to obese compared to those who remained at a normal BMI were found to have a 2 times higher odds (OR=2.1; 95% CI: 1.11-3.79) of developing breast cancer. No significant association was observed for women who increased to overweight. However, a more pronounced association was observed in non-Hispanic black women (OR=6.6; 95% CI: 1.68-25.86) and a significant association observed when they increased from normal to overweight (OR=4.2; 95% CI: 1.02-17.75). Conclusions Becoming obese after age 25 is associated with increased risk of breast cancer in women over 50 years old, with non-Hispanic black women being at greatest risk.

The role of cancer in marijuana and prescription opioid use in the United States: A population‐based analysis from 2005 to 2014

“…Thus, we do not have additional information about the respondent cancer status that may affect substance use (ie, currently undergoing treatment vs in remission), and it is possible that these data may not be generalizable to all patients with cancer with a verified diagnosis. However, NHANES data (and this specific cancer variable) have been used to investigate cancer in other studies . Finally, we defined opioid use on the basis of filling a prescription within the last 30 days, and this may be an underrepresentation of total opioid use.…”

“…However, NHANES data (and this specific cancer variable) have been used to investigate cancer in other studies. 29,30 Finally, we defined opioid use on the basis of filling a prescription within the last 30 days, and this may be an underrepresentation of total opioid use. Although the complex, multistage probability sampling method of NHANES data collection introduces statistical challenges, our analysis effectively accounts for confounding variables via propensity score matching and multivariable analyses.…”

“…Respondents were grouped by the reported diagnosis of cancer. For respondents with multiple cancer diagnoses, the primary cancer site was defined as the first site reported …”

“…For respondents with multiple cancer diagnoses, the primary cancer site was defined as the first site reported. 29,30 Demographic variables of interest included age, sex, race, education, self-reported health status, low income, and insurance coverage. Age was analyzed as a continuous variable.…”

Changes in Adult BMI and Waist Circumference Are Associated with Increased Risk of Advanced Colorectal Neoplasia

“…In calculating BMI change, BMI at age 21 was the baseline BMI and was compared with BMI at Time 2 (current, i.e., time of screening). BMI changes were defined in 9 specific categories within three broad areas [31]: A. Maintained BMI : 1) Stable-Normal : having normal BMI at both time points; 2) Stable-Overweight : being overweight at both time points; and 3) Stable-Obese : being obese at both time points.…”