Adrenoceptor activity and adenylate cyclase inhibition in depression

Abou‐Saleh, Mohammed T.; Collins, James; George, Armia; Rommelspacher, Hans

doi:10.1192/bjp.165.2.276b

Cited by 6 publications

(5 citation statements)

References 2 publications

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“…Previous studies demonstrated lower or similar forskolin-stimulated cAMP levels in clinically depressed individuals compared with controls (Abu-Saleh et al., 1994; Gracia-Sevilla et al., 1990; Mazzola-Pomietto et al., 1994; Menninger & Tabakoff, 1997; Newman et al, 1992) or in the brains of suicide victims (Cowburn et al, 1994). This may be the result of modifications in the central and peripheral nervous system generated by the depression itself or by antidepressant drugs (Buckholtz et al, 1988; Ebstein et al, 1988; Ossofsky, 1976) or by changes in brain functions coexhibited with psychiatric morbidity (Davidson et al, 2002).…”

Section: Discussionmentioning

confidence: 89%

“…In clinically depressed patients, forskolin-stimulated cAMP levels were found to be lower than controls (Cowburn et al., 1994; Menninger & Tabakoff, 1997) or similar to them (Newman et al, 1992). Also, contrasting results were reported for cAMP stimulation with prostaglandin E1 or via Beta-adrenergic receptors (Abu-Saleh et al, 1994; Garcia-Sevilla et al, 1990; Mazzola-Pomietto et al, 1994).…”

Section: Introductionmentioning

confidence: 85%

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The Association of Forskolin-Stimulated Cyclic AMP Levels in Peripheral Blood Mononuclear Cells of Healthy People with Depressive Mood and Sense of Coherence

Cohen

Sklair-Tavron

Pollack³

2004

Journal of Psychophysiology

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Background: Depressive mood exerts a suppressive effect on immune functions, mediated through neuro-immune processes. Research suggests a protective effect of sense of coherence (SOC) on psychological and physical health in face of stressful life events. Cyclic adenosine monophosphate (cAMP) is a cellular second messenger that is coupled to certain receptors expressed on peripheral blood mononuclear cells (PBMC). By interfering with the neuro-endocrine-immune axis, depressive mood may induce changes in intracellular cAMP levels in PBMC. Aims of study: To examine a possible association of SOC, stressful life events during the previous year, depressive mood, and cAMP levels. Methods: Fifteen male volunteers participated in the study. They completed the SOC and Zung's depression questionnaires and stressful life events inventory. Basic cAMP level and forskolin-stimulated cAMP production were measured in PBMC. Results: Forskolin-stimulated cAMP production was significantly higher in individuals who reported higher depressive mood, more stressful life events, or lower SOC scores. SOC scores explained 40% of forskolin-stimulated cAMP production. Basal cAMP levels could not be correlated with psychological scores. Age or education level did not affect forskolin-stimulated or basal cAMP levels. Conclusions: Our data suggest that high forskolin-stimulated cAMP production in PBMC is associated with low SOC, which points to availability of personal resources for coping with stressful life events. Further examination of the possible mediating role of SOC in relation to depressive mood and neuroimmune functions is needed.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 85%

The Association of Forskolin-Stimulated Cyclic AMP Levels in Peripheral Blood Mononuclear Cells of Healthy People with Depressive Mood and Sense of Coherence

Cohen

Sklair-Tavron

Pollack³

2004

Journal of Psychophysiology

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“…6 However, the most commonly used methodology for studying adenylyl cyclase activity is through direct measurement of cAMP accumulation from adenosine 5'-triphosphate (ATP) following agonist stimulation. 32 P-radiolabeled ATP is converted to 3 2 P cAMP, which is then separated and quantified through a double-step Dowex-neutral alumina chromatography. 7 The traditional methodology from Salomon 7 can be summarized as follows.…”

Section: Methodowgic Tools For Study-ing Adenylyl Cyclase Activitymentioning

confidence: 99%

“…The final eluate, obtained with imidazole, is collected in scintillation vials. The sample radioactivity is then analyzed by liquid scintillation/duallabel [ 32…”

Section: Methodowgic Tools For Study-ing Adenylyl Cyclase Activitymentioning

confidence: 99%

“…8 This last methodology, although used less frequently, appears to ensure a better chromatographic separation. In fact, unreacted 32 P ATP and proteins are eliminated by precipitation and centrifugation, as well as unreacted 32 p ATP. The former method yields denaturation of proteins but not their complete elimination during chromatography.…”

Section: Methodowgic Tools For Study-ing Adenylyl Cyclase Activitymentioning

confidence: 99%

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Adenylyl Cyclase Activity and Mood Disorders: Preliminary Data in Human Brain Postmortem

Palego¹,

Giromella²,

Mazzoni³

et al. 1998

CNS spectr.

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During the past decade, an increasing interest has been shifted from the study of neuroreceptors to their links with second-messenger pathways. In the present article, we shall briefly review the methodological tools for evaluating adenylyl cyclase activity in several human brain and peripheral models, as well as the studies suggesting its involvement in the pathophysiology of mood disorders. We shall present also some preliminary data obtained in our laboratory providing evidence for the measurement of serotonin-sensitive adenylyl cyclase activity in human brain postmortem.

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cDNA gene expression profile of rat hippocampus after chronic treatment with antidepressant drugs

Drigues

Poltyrev

Bejar

et al. 2003

Journal of Neural Transmission

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Adrenoceptor activity and adenylate cyclase inhibition in depression

Abstract: CORRESPONDENCE dopamine. In our two healthy volunteers the oppo site may have happened, and the combination of amphetamine with haloperidol may have caused marked dystonia by potentiation of dopamine release.

Cited by 6 publications

References 2 publications

The Association of Forskolin-Stimulated Cyclic AMP Levels in Peripheral Blood Mononuclear Cells of Healthy People with Depressive Mood and Sense of Coherence

The Association of Forskolin-Stimulated Cyclic AMP Levels in Peripheral Blood Mononuclear Cells of Healthy People with Depressive Mood and Sense of Coherence

Adenylyl Cyclase Activity and Mood Disorders: Preliminary Data in Human Brain Postmortem

cDNA gene expression profile of rat hippocampus after chronic treatment with antidepressant drugs

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