Adolescent depression: A placebo-controlled fluoxetine treatment study and follow-up

Extended Open-Label Fluoxetine Treatment of Adolescents with Major Depression

“…In the absence of placebo controls, though, the clinically observed improvements might not have been genuinely due to fluoxetine; for example, placebo-treated control subjects might have shown comparable symptom changes in a similar time course. The rate of apparent treatment response (88%) in our open trial is somewhat higher than reported by others (Simeon et al 1990, Boulos et al 1992, Jain et al 1992) and might be attributable to the longer trial length. Another difference between this study and prior work is that our patients did not consistently receive any other psychoactive medication while be-229 ing treated with fluoxetine, raising the likelihood that the improvements observed were due to the fluoxetine in combination with the psychosocial interventions.…”

Extended Open-Label Fluoxetine Treatment of Adolescents with Major Depression

“…In the absence of placebo controls, though, the clinically observed improvements might not have been genuinely due to fluoxetine; for example, placebo-treated control subjects might have shown comparable symptom changes in a similar time course. The rate of apparent treatment response (88%) in our open trial is somewhat higher than reported by others (Simeon et al 1990, Boulos et al 1992, Jain et al 1992) and might be attributable to the longer trial length. Another difference between this study and prior work is that our patients did not consistently receive any other psychoactive medication while be-229 ing treated with fluoxetine, raising the likelihood that the improvements observed were due to the fluoxetine in combination with the psychosocial interventions.…”

Fluoxetine treatment of prepubescent rats produces a selective functional reduction in the 5-HT2A receptor-mediated stimulation of oxytocin

“…This effect was somewhat smaller than the attenuation in body weight gain previously observed in adult rats ($7-9%) following a similar fluoxetine treatment paradigm Raap et al, 1999b;Zhang et al, 2000). Consistent with these data, adolescent patients treated with fluoxetine also exhibit a small decrease in body weight (Simeon et al, 1990). A recent case report in children showed growth attenuation or arrest with normal weight gain during fluoxetine treatment (Weintrob et al, 2002).…”

Efficacy of antidepressant medication with depressed youth: What psychologists should know.

“…Two studies have evaluated fluoxetine effectiveness with adolescents and young adults. In the only double-blind, placebocontrolled study of fluoxetine with youth that we found, Simeon, Dinicola, Ferguson, and Copping (1990) reported no statistically significant differences between the efficacy of 20 to 60 mg/day of fluoxetine and placebo with 40 adolescents ages 13 to 18 years. In a rather vaguely worded results section, the authors stated, "Approximately two-thirds of the patients showed marked or moderate clinical global improvement with both fluoxetine and placebo" (p. 791).…”

Extended Open-Label Fluoxetine Treatment of Adolescents with Major Depression

“…In the absence of placebo controls, though, the clinically observed improvements might not have been genuinely due to fluoxetine; for example, placebo-treated control subjects might have shown comparable symptom changes in a similar time course. The rate of apparent treatment response (88%) in our open trial is somewhat higher than reported by others (Simeon et al 1990, Boulos et al 1992, Jain et al 1992) and might be attributable to the longer trial length. Another difference between this study and prior work is that our patients did not consistently receive any other psychoactive medication while be-229 ing treated with fluoxetine, raising the likelihood that the improvements observed were due to the fluoxetine in combination with the psychosocial interventions.…”

Fluoxetine treatment of prepubescent rats produces a selective functional reduction in the 5-HT2A receptor-mediated stimulation of oxytocin

“…This effect was somewhat smaller than the attenuation in body weight gain previously observed in adult rats ($7-9%) following a similar fluoxetine treatment paradigm Raap et al, 1999b;Zhang et al, 2000). Consistent with these data, adolescent patients treated with fluoxetine also exhibit a small decrease in body weight (Simeon et al, 1990). A recent case report in children showed growth attenuation or arrest with normal weight gain during fluoxetine treatment (Weintrob et al, 2002).…”

Efficacy of antidepressant medication with depressed youth: What psychologists should know.

“…Two studies have evaluated fluoxetine effectiveness with adolescents and young adults. In the only double-blind, placebocontrolled study of fluoxetine with youth that we found, Simeon, Dinicola, Ferguson, and Copping (1990) reported no statistically significant differences between the efficacy of 20 to 60 mg/day of fluoxetine and placebo with 40 adolescents ages 13 to 18 years. In a rather vaguely worded results section, the authors stated, "Approximately two-thirds of the patients showed marked or moderate clinical global improvement with both fluoxetine and placebo" (p. 791).…”

Extended Open-Label Fluoxetine Treatment of Adolescents with Major Depression

“…In the absence of placebo controls, though, the clinically observed improvements might not have been genuinely due to fluoxetine; for example, placebo-treated control subjects might have shown comparable symptom changes in a similar time course. The rate of apparent treatment response (88%) in our open trial is somewhat higher than reported by others (Simeon et al 1990, Boulos et al 1992, Jain et al 1992) and might be attributable to the longer trial length. Another difference between this study and prior work is that our patients did not consistently receive any other psychoactive medication while be-229 ing treated with fluoxetine, raising the likelihood that the improvements observed were due to the fluoxetine in combination with the psychosocial interventions.…”

Fluoxetine treatment of prepubescent rats produces a selective functional reduction in the 5-HT2A receptor-mediated stimulation of oxytocin

“…This effect was somewhat smaller than the attenuation in body weight gain previously observed in adult rats ($7-9%) following a similar fluoxetine treatment paradigm Raap et al, 1999b;Zhang et al, 2000). Consistent with these data, adolescent patients treated with fluoxetine also exhibit a small decrease in body weight (Simeon et al, 1990). A recent case report in children showed growth attenuation or arrest with normal weight gain during fluoxetine treatment (Weintrob et al, 2002).…”

Efficacy of antidepressant medication with depressed youth: What psychologists should know.

“…Two studies have evaluated fluoxetine effectiveness with adolescents and young adults. In the only double-blind, placebocontrolled study of fluoxetine with youth that we found, Simeon, Dinicola, Ferguson, and Copping (1990) reported no statistically significant differences between the efficacy of 20 to 60 mg/day of fluoxetine and placebo with 40 adolescents ages 13 to 18 years. In a rather vaguely worded results section, the authors stated, "Approximately two-thirds of the patients showed marked or moderate clinical global improvement with both fluoxetine and placebo" (p. 791).…”