Admission Visfatin Levels Predict Pancreatic and Peripancreatic Necrosis in Acute Pancreatitis and Correlate With Clinical Severity

Abstract

Admission visfatin concentration serves as an early predictive marker of peripancreatic necrosis and clinical severity in acute pancreatitis. Visfatin may have potential for clinical use as a new and diagnostic serum marker.

Soluble CD163 is increased in patients with acute pancreatitis independent of disease severity

“…Similar results have been obtained for visfatin which is also released from monocytes/macrophages (Dahl et al, 2007;Schaffler et al, 2011). CD14 expression of circulating monocytes is induced and higher systemic soluble CD14 is linked to inflammation and multiorgan failure in acute pancreatitis (Rahman et al, 2007).…”

“…There are some limitations to our study. Of note, in total 8 patients with unknown cause of pancreatitis were excluded (Schaffler et al, 2010;Schaffler et al, 2011), and these would presumably include patients with idiopathic pancreatitis. Since studies suggest that idiopathic pancreatitis can be severe, future examinations should add a careful and separate evaluation of patients suffering from idiopathic pancreatitis as a subgroup.…”

“…Additional exclusion criteria were: Unknown cause of pancreatitis, not consenting to participate in the study, and age b18 or N85 years. Detailed inclusion/exclusion criteria and procedure of patient inclusion have been summarized earlier (Schaffler et al, 2010;Schaffler et al, 2011).…”

“…Levels of sCD163 were measured in a recently described cohort of 50 patients (20 females) with a BMI of 29.9 ± 7.8 kg/m 2 and age of 57.9 ± 16.2 years with acute pancreatitis (Schaffler et al, 2010;Schaffler et al, 2011;Shao et al, 2012). Patients were admitted to the University Hospital of Regensburg, Germany from August 2002 until August 2007.…”

Peripancreatic fat necrosis worsens acute pancreatitis independent of pancreatic necrosis via unsaturated fatty acids increased in human pancreatic necrosis collections

“…Agents elevated in body fluids of patients with severe acute pancreatitis (SAP) and animal models of acute pancreatitis (AP)1 2 include adipokines,3 4proteases like trypsin,5–8 unsaturated fatty acids (UFAs) such as oleic and linoleic acid (LA)1 9 10 or cytokines including interleukin (IL)-1β,11 IL-6,12–15 IL-8,12 15 16 monocyte chemotactic protein-1 (MCP-1)17 and tumour necrosis factor-alpha (TNF-α) 13. Scoring systems to risk stratify AP include these 17–20.…”