1984
DOI: 10.1001/archderm.120.7.941
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Adjuvant therapy of pemphigus

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Cited by 59 publications
(77 citation statements)
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“…In patients with P. vulgaris there is pronounced imbalance of helper T -T supressor ratio, which is restored by corticosteroid therapy. 24 Oral lesions of Pemphigus Vulgaris may respond partially to topical or intralesional corticosteroids. Systemic corticosteroids.…”
Section: Corticosteroidsmentioning
confidence: 99%
“…In patients with P. vulgaris there is pronounced imbalance of helper T -T supressor ratio, which is restored by corticosteroid therapy. 24 Oral lesions of Pemphigus Vulgaris may respond partially to topical or intralesional corticosteroids. Systemic corticosteroids.…”
Section: Corticosteroidsmentioning
confidence: 99%
“…Pemphigus vulgaris has an average age of onset of 40–60 years with oral lesions found in two‐thirds of patients . Pemphigus vulgaris was almost invariably fatal before the 1950s, owing to uncontrolled fluid and protein loss or opportunistic infection . However, since this time, with the advent of corticosteroids, life expectancy has increased significantly and now the mortality rate is approximately 6%, usually associated with the side effects of immunosuppressive therapy used to control the disease .…”
Section: Introductionmentioning
confidence: 99%
“…Pemphigus vulgaris was almost invariably fatal before the 1950s, owing to uncontrolled fluid and protein loss or opportunistic infection . However, since this time, with the advent of corticosteroids, life expectancy has increased significantly and now the mortality rate is approximately 6%, usually associated with the side effects of immunosuppressive therapy used to control the disease . Initial treatment for PV is prompt conventional immunosuppressive therapy in the form of high‐dose tapering steroids with titrated adjunctive steroid sparing immunomodulatory drugs.…”
Section: Introductionmentioning
confidence: 99%
“…However, only few large scale studies have been performed in the past because of the low incidence of the disease. Thus, although the steroid treatments have dramatically reduced mortality (16), no optimal therapy is ascertained. Preclinical testing and the use of animal models may therefore be of value when designing and optimizing new clinical trials.…”
Section: Introductionmentioning
confidence: 99%