Adjuvant narrow band UVB improves the efficacy of oral azithromycin for the treatment of moderate to severe inflammatory facial acne vulgaris

Rassai, Sima; Rafeie, Esmaeil; Ramírez-Fort, Marigdalia K.; Feily, Amir

doi:10.4103/0974-2077.146664

Cited by 14 publications

(7 citation statements)

References 19 publications

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“…Alternative acne treatments include blue light, ultraviolet (UV) phototherapy, and photodynamic therapy [117,118,119]. These approaches could improve acne by reshaping the skin microbiota and lowering C. acnes counts within the lesions.…”

Section: Acne Treatment and Skin Microbesmentioning

confidence: 99%

Potential Role of the Microbiome in Acne: A Comprehensive Review

Lee

Byun

Kim

2019

JCM

191

195

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Acne is a highly prevalent inflammatory skin condition involving sebaceous sties. Although it clearly develops from an interplay of multiple factors, the exact cause of acne remains elusive. It is increasingly believed that the interaction between skin microbes and host immunity plays an important role in this disease, with perturbed microbial composition and activity found in acne patients. Cutibacterium acnes (C. acnes; formerly called Propionibacterium acnes) is commonly found in sebum-rich areas and its over-proliferation has long been thought to contribute to the disease. However, information provided by advanced metagenomic sequencing has indicated that the cutaneous microbiota in acne patients and acne-free individuals differ at the virulent-specific lineage level. Acne also has close connections with the gastrointestinal tract, and many argue that the gut microbiota could be involved in the pathogenic process of acne. The emotions of stress (e.g., depression and anxiety), for instance, have been hypothesized to aggravate acne by altering the gut microbiota and increasing intestinal permeability, potentially contributing to skin inflammation. Over the years, an expanding body of research has highlighted the presence of a gut–brain–skin axis that connects gut microbes, oral probiotics, and diet, currently an area of intense scrutiny, to acne severity. This review concentrates on the skin and gut microbes in acne, the role that the gut–brain–skin axis plays in the immunobiology of acne, and newly emerging microbiome-based therapies that can be applied to treat acne.

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Section: Acne Treatment and Skin Microbesmentioning

confidence: 99%

Potential Role of the Microbiome in Acne: A Comprehensive Review

Lee

Byun

Kim

2019

JCM

191

195

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“…In fact, UV's impact on acne had been widely a few studies. [18][19][20] However, more studies reached a same conclusion that this beneficial effect was slight and not sufficient for therapeutic use considering side-effect of its long-term use such as carcinogenesis and photoaging. 21,22 As a result, UV-based therapy was thought obsolete in the treatment of acne vulgaris.…”

Section: Overall and Interactive Effects Of Low Levels Of Uv Exposurementioning

confidence: 99%

Long‐term exposure to low levels of ambient UVB are associated with a decreased risk of moderate‐to‐severe acne: A retrospective cohort study in college students

Chen

Xiao

et al. 2023

Photoderm Photoimm Photomed

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Background As a crucial component of solar radiation, the association between exposure to ambient ultraviolet (UV) radiation and acne remains unclear. Methods This was a multicenter retrospective cohort study of incoming college students in five universities of China. Previous exposure (6 years prior to enrollment) to different wavelengths of ambient UVs were obtained from public repositories by linking to individual hometown addresses. Logistic models were applied to assess the relationship between ambient UV exposure and acne. Subgroup analysis was conducted by sun protection behaviors and time of daily sun exposure. Overall effect and single effect of exposure to four different wavelengths of UVs (305, 310, 324, and 380 nm) were estimated by Bayesian kernel machine regression (BKMR). Results A total of 19,939 participants was included for analysis. Analysis in all participants showed a significant association between log‐transformation levels of exposure to UV at 305 nm (log (UV 305 nm)) and acne (OR = 0.77, p = .021). The effect size was stronger in participants reporting no sun protection habit. Both UVs at 305 nm (OR = 0.51, p = .001) and 310 nm (OR = 0.50, p = .012) were associated a decreased risk of acne in participants reporting no sun protection habit. This inverse association was also observed in those exposed to low levels of UV (<1 h/day). The BKMR indicated consistent results that low levels of exposure to UVs combination and UVs at 305 and 310 nm were associated with a lower risk of acne. Conclusion Long‐term exposure to relatively low levels of ambient UVB are associated with a decreased risk of moderate‐to‐severe acne in college students.

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“…A case report by Zeichner et al showed improvement in inflammatory papules and pustules in a pregnant patient after two months of NB-UVB therapy [ 55 ]. A recent study of 104 patients demonstrated that oral azithromycin in combination with NB-UVB led to improvement of inflammatory papules when compared to oral azithromycin alone [ 56 ].…”

Section: Reviewmentioning

confidence: 99%

An Update on Narrowband Ultraviolet B Therapy for the Treatment of Skin Diseases

Myers¹,

Kheradmand²,

Miller³

2021

Cureus

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The objective of this review is to provide an update on narrowband ultraviolet B (NB-UVB) as a treatment for various skin conditions. NB-UVB works by suppressing the cutaneous cell-mediated immune response and has been shown to be an efficacious and clinically tolerable treatment for a range of inflammatory dermatoses. A literature search was conducted by advanced searches of PubMed for NB-UVB treatment of dermatologic skin diseases with a focus on reports from 2010 to 2021, including both office-based and home-based phototherapy (HBPT). Data were prioritized based on studies with a high level of evidence using the Oxford Evidence-Based Medicine guidance. We found that NB-UVB continues to serve as an effective form of therapy for several cutaneous conditions, including vitiligo, psoriasis, atopic dermatitis, mycosis fungoides, and other inflammatory dermatoses. The recent introduction of Janus kinase inhibitors in combination with NB-UVB suggests future promise in the treatment of vitiligo. Despite its rise in popularity, a decline was seen in office-based NB-UVB treatment during the coronavirus disease 2019 pandemic. Options are available to deliver NB-UVB at home with comparable efficacy to office-based treatments. In conclusion, for a select group of patients and conditions, NB-UVB continues to serve as an effective treatment modality with minimal side effects, with HBPT serving as an option to improve patient compliance.

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Adjuvant narrow band UVB improves the efficacy of oral azithromycin for the treatment of moderate to severe inflammatory facial acne vulgaris

Cited by 14 publications

References 19 publications

Potential Role of the Microbiome in Acne: A Comprehensive Review

Potential Role of the Microbiome in Acne: A Comprehensive Review

Long‐term exposure to low levels of ambient UVB are associated with a decreased risk of moderate‐to‐severe acne: A retrospective cohort study in college students

An Update on Narrowband Ultraviolet B Therapy for the Treatment of Skin Diseases

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