Adjuvant gonadotropin-releasing hormone analogues for the prevention of chemotherapy induced premature ovarian failure in premenopausal women

Fertility Preservation Counseling for Pediatric and Adolescent Cancer Patients

“…However, many of the recent studies report improving fertility in the adult population. 15,16 As previously discussed, this study's response rate is an obvious limitation, but it is consistent with the findings of other previous published reports. 12,17,18 Compensation may be a future strategy to improve response rates.…”

Fertility Preservation Counseling for Pediatric and Adolescent Cancer Patients

“…However, many of the recent studies report improving fertility in the adult population. 15,16 As previously discussed, this study's response rate is an obvious limitation, but it is consistent with the findings of other previous published reports. 12,17,18 Compensation may be a future strategy to improve response rates.…”

Controversies over the use of GnRH agonists for reduction of chemotherapy-induced gonadotoxicity

“…Also, its use almost doubled the chance of achieving subsequent pregnancies (OR 1.83; p ¼ 0.041; 33 vs. 19 patients) 11 . These data are in accordance with those from previous meta-analyses that showed similar results, supporting GnRH co-treatment during chemotherapy 5,12 . In the meta-analysis by Del Mastro and colleagues, including nine randomized, controlled trials, and considering three different cancers, 225 events of POF were reported among 765 patients (29.4%).…”

Preservation of gonadal function in women undergoing chemotherapy: a systematic review and meta-analysis of the potential role for gonadotropin-releasing hormone agonists

“…Given the importance of fertility and gonadal function to patient quality of life, the long-term effects of chemotherapy treatment on ovarian function must not be ignored. This systematic review, in addition to many prior studies [15,[35][36][37][38][39][40][41][42][43][44][45][46], supports the use of GnRHa during gonadotoxic chemotherapy for the preservation of ovarian function.…”

Fertility Preservation Counseling for Pediatric and Adolescent Cancer Patients

“…However, many of the recent studies report improving fertility in the adult population. 15,16 As previously discussed, this study's response rate is an obvious limitation, but it is consistent with the findings of other previous published reports. 12,17,18 Compensation may be a future strategy to improve response rates.…”

Controversies over the use of GnRH agonists for reduction of chemotherapy-induced gonadotoxicity

“…Also, its use almost doubled the chance of achieving subsequent pregnancies (OR 1.83; p ¼ 0.041; 33 vs. 19 patients) 11 . These data are in accordance with those from previous meta-analyses that showed similar results, supporting GnRH co-treatment during chemotherapy 5,12 . In the meta-analysis by Del Mastro and colleagues, including nine randomized, controlled trials, and considering three different cancers, 225 events of POF were reported among 765 patients (29.4%).…”

Preservation of gonadal function in women undergoing chemotherapy: a systematic review and meta-analysis of the potential role for gonadotropin-releasing hormone agonists

“…Given the importance of fertility and gonadal function to patient quality of life, the long-term effects of chemotherapy treatment on ovarian function must not be ignored. This systematic review, in addition to many prior studies [15,[35][36][37][38][39][40][41][42][43][44][45][46], supports the use of GnRHa during gonadotoxic chemotherapy for the preservation of ovarian function.…”

Fertility Preservation Counseling for Pediatric and Adolescent Cancer Patients

“…However, many of the recent studies report improving fertility in the adult population. 15,16 As previously discussed, this study's response rate is an obvious limitation, but it is consistent with the findings of other previous published reports. 12,17,18 Compensation may be a future strategy to improve response rates.…”

Controversies over the use of GnRH agonists for reduction of chemotherapy-induced gonadotoxicity

“…Also, its use almost doubled the chance of achieving subsequent pregnancies (OR 1.83; p ¼ 0.041; 33 vs. 19 patients) 11 . These data are in accordance with those from previous meta-analyses that showed similar results, supporting GnRH co-treatment during chemotherapy 5,12 . In the meta-analysis by Del Mastro and colleagues, including nine randomized, controlled trials, and considering three different cancers, 225 events of POF were reported among 765 patients (29.4%).…”

Preservation of gonadal function in women undergoing chemotherapy: a systematic review and meta-analysis of the potential role for gonadotropin-releasing hormone agonists

“…Given the importance of fertility and gonadal function to patient quality of life, the long-term effects of chemotherapy treatment on ovarian function must not be ignored. This systematic review, in addition to many prior studies [15,[35][36][37][38][39][40][41][42][43][44][45][46], supports the use of GnRHa during gonadotoxic chemotherapy for the preservation of ovarian function.…”