Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes

Kováčová, Zuzana; Tharp, William G.; Liu, Dianxin; Wei, Wan; Xie, Hui; Collins, Sheila; Pratley, Richard E.

doi:10.1002/oby.21418

Cited by 75 publications

(82 citation statements)

References 38 publications

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“…Little is known about the mechanisms responsible for the improvements in the NP-induced metabolic effects, but these may relate to NP secretion as well as NP receptor expression and post-receptor signalling. Indeed, in humans, whole-body insulin sensitivity was recently shown to strongly correlate with NPRA in subcutaneous AT (153) and skeletal muscle (124). In line with this, AT (148,153) and skeletal muscle (124) NPRC expression was negatively associated with whole-body insulin sensitivity.…”

Section: Natriuretic Peptide and Insulin Sensitivitymentioning

confidence: 62%

“…Indeed, in humans, whole-body insulin sensitivity was recently shown to strongly correlate with NPRA in subcutaneous AT (153) and skeletal muscle (124). In line with this, AT (148,153) and skeletal muscle (124) NPRC expression was negatively associated with whole-body insulin sensitivity. Additionally, NP degradation by NEP (74) may contribute to the development of IR (as was shown in obese Zucker rats) (184,185).…”

Section: Natriuretic Peptide and Insulin Sensitivitymentioning

confidence: 62%

“…Moreover, exercise training enhances mitochondrial function at the level of the skeletal muscle and ultimately insulin sensitivity , at least partly because of an increased NPRA expression and signalling , the latter also resulting from caloric‐restriction‐induced weight loss in obese subjects . Of interest, pharmacologically improved insulin sensitivity (by the anti‐diabetic drug pioglitazone) was accompanied by an increased NPRA/NPRC ratio in subcutaneous AT of obese individuals with T2DM . Liraglutide‐induced weight loss in obese individuals with T2DM was correlated with change in NP levels, although the mechanism responsible remained elusive .…”

Section: Impact Of Exercise/lifestyle Intervention On Natriuretic Pepmentioning

confidence: 99%

“…Of interest, the presence of low-glucose conditions together with insulin stimulation abolished NPRC expression to basal levels, indicating the existence of a 'nutritional signalling' in NPRC regulation (122). The relative ratio of NPRA to NPRC mRNA levels in subcutaneous AT was decreased depending on glucometabolic status because patients with T2DM had the lowest ratio compared with subjects with normal glucose tolerance or impaired glucose metabolism (148,153). Acute increases in systemic blood glucose decreased circulating Nterminal proANP in lean, overweight and obese subjects, a mechanism mediated through glucose-induced miR-425 expression (154), a negative regulator of NPRA (155).…”

Section: Natriuretic Peptide and Adipose Tissue Lipolysismentioning

confidence: 99%

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Natriuretic peptides in the control of lipid metabolism and insulin sensitivity

et al. 2017

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Natriuretic peptides have long been known for their cardiovascular function. However, a growing body of evidence emphasizes the role of natriuretic peptides in human substrate and energy metabolism, thereby connecting the heart with several insulin-sensitive organs like adipose tissue, skeletal muscle and liver. Obesity may be associated with an impaired regulation of the natriuretic peptide system, also indicated as a natriuretic handicap. Evidence points towards a contribution of this natriuretic handicap to the development of obesity, type 2 diabetes mellitus and cardiometabolic complications, although the causal relationship is not fully understood. Nevertheless, targeting the natriuretic peptide pathway may improve metabolic health in obesity and type 2 diabetes mellitus. This review will focus on current literature regarding the metabolic roles of natriuretic peptides with emphasis on lipid metabolism and insulin sensitivity. Furthermore, it will be discussed how exercise and lifestyle intervention may modulate the natriuretic peptide-related metabolic effects.

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Section: Natriuretic Peptide and Insulin Sensitivitymentioning

confidence: 62%

Section: Natriuretic Peptide and Insulin Sensitivitymentioning

confidence: 62%

Section: Impact Of Exercise/lifestyle Intervention On Natriuretic Pepmentioning

confidence: 99%

Section: Natriuretic Peptide and Adipose Tissue Lipolysismentioning

confidence: 99%

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Natriuretic peptides in the control of lipid metabolism and insulin sensitivity

et al. 2017

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“…Several studies suggested that adiponectin resistance might lead to elevated levels of adiponectin in patients with heart failure, which would in turn predict high CVD mortality. 48,49 In addition, the natriuretic peptide system including B-type natriuretic peptide (BNP) and the N-terminal fragment of its prohormone (NT-pro BNP) plays an important role in adipose tissue metabolism, 50,51 which might influence the secretion of adiponectin. Some studies demonstrated that NT-pro BNP and adiponectin had a significantly positive correlation and both could predict a high mortality in participants with chronic heart failure or chronic kidney disease.…”

Section: Discussionmentioning

confidence: 99%

Plasma Levels of Fatty Acid–Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes

Liu

Ding

Chiuve

et al. 2016

ATVB

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Objective To examine select adipokines, including fatty acid-binding protein 4 (FABP4), retinol-binding protein 4 (RBP4), and high-molecular weight (HMW) adiponectin in relation to cardiovascular disease (CVD) mortality among patients with type 2 diabetes (T2D). Approach and Results Plasma levels of FABP4, RBP4, and HMW adiponectin were measured in 950 men with T2D in the Health Professionals Follow-up Study. After an average of 22 years of follow up (1993–2015), 580 deaths occurred, of whom 220 died of CVD. After multivariate adjustment for covariates, higher levels of FABP4 were significantly associated with a higher CVD mortality: comparing extreme tertiles, the hazard ratio (HR) and 95% confidence interval (CI) of CVD mortality was 1.78 (1.22, 2.59; P trend=0.001). A positive association was also observed for HMW adiponectin: the HR (95% CI) was 2.07 (1.42, 3.06; P trend=0.0002), comparing extreme tertiles, whereas higher RBP4 levels were non-significantly associated with a decreased CVD mortality with an HR (95% CI) of 0.73 (0.50, 1.07; P trend=0.09). A Mendelian randomization (MR) analysis suggested that the causal relationships of HMW adiponectin and RBP4 would be directionally opposite to those observed based on the biomarkers, although none of the MR associations achieved statistical significance. Conclusions These data suggest that higher levels of FABP4 and HMW adiponectin are associated with elevated CVD mortality among men with T2D. Biological mechanisms underlying these observations deserve elucidation, but the associations of HMW adiponectin may partially reflect altered adipose tissue functionality among T2D patients.

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Contribution of Maladaptive Adipose Tissue Expansion to Development of Cardiovascular Disease

Jia

Sowers

2016

Comprehensive Physiology

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The overweight and obesity epidemic has led to an increase in the metabolic syndrome and associated cardiovascular disease (CVD). These abnormalities include insulin resistance, type 2 diabetes mellitus, vascular stiffness, hypertension, stroke, and coronary heart disease. Visceral white adipocyte tissue (WAT) expansion and associated fibrosis/stiffness of WAT promote insulin resistance and CVD through increases in proinflammatory adipokines, oxidative stress, activation of renin-angiotensin-aldosterone system, dysregulation of adipocyte apoptosis and autophagy, dysfunctional immune modulation, and adverse changes in the gut microbiome. The expansion of WAT is partly determined by activation of peroxisome proliferator-activated receptor gamma and mammalian target of rapamycin/ribosomal S6 kinase signaling pathways. Further, the chronic activation of these signaling pathways may not only induce adipocyte hypertrophy and fibrosis, but also contribute to systemic inflammation, and impairment of insulin metabolic signaling in fat, liver, and skeletal muscle tissue. Therefore, the interplay of adipocyte dysfunction, maladaptive immune and inflammatory responses, and associated metabolic disorders often coexist leading to systemic low-grade inflammation and insulin resistance that are associated with increased CVD in obese individuals. © 2017 American Physiological Society. Compr Physiol 7:253-262, 2017.

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Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes

Cited by 75 publications

References 38 publications

Natriuretic peptides in the control of lipid metabolism and insulin sensitivity

Natriuretic peptides in the control of lipid metabolism and insulin sensitivity

Plasma Levels of Fatty Acid–Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes

Contribution of Maladaptive Adipose Tissue Expansion to Development of Cardiovascular Disease

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