2003
DOI: 10.1096/fj.03-0678fje
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Abstract: We investigated the influences of short-term and lifespan-prolonging long-term caloric restriction (LCR) on gene expression in white adipose tissue (WAT). Over 11,000 genes were examined using high-density oligonucleotide microarrays in four groups of 10- to 11-month-old male C57Bl6 mice that were either fasted for 18 h before death (F), subjected to short-term caloric restriction for 23 days (SCR), or LCR for 9 months and compared with nonfasted control (CO) mice. Only a few transcripts of F and SCR were diff… Show more

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Cited by 152 publications
(130 citation statements)
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“…In support of this, Srebp‐1c activated the PGC‐1α promoter in brown adipocytes (Hao et al ., 2010). Our findings supported other reports that multilocular adipocytes, which are characteristically similar to brown adipocytes, were present in WAT in CR mice (Higami et al ., 2004). Moreover, it is likely that Srebp‐1c is required for CR‐associated upregulation of γ‐Gcs gene expression and Sirt3 protein expression in WAT.…”
Section: Discussionmentioning
confidence: 99%
“…In support of this, Srebp‐1c activated the PGC‐1α promoter in brown adipocytes (Hao et al ., 2010). Our findings supported other reports that multilocular adipocytes, which are characteristically similar to brown adipocytes, were present in WAT in CR mice (Higami et al ., 2004). Moreover, it is likely that Srebp‐1c is required for CR‐associated upregulation of γ‐Gcs gene expression and Sirt3 protein expression in WAT.…”
Section: Discussionmentioning
confidence: 99%
“…Similar studies have evaluated the transcriptome in adipose tissue as a function of aging and/or caloric restriction in rodent models (Higami et al 2004;Fu et al 2006;Linford et al 2007;Swindell 2008). Studies have examined 10-11-month-old male C57BL/6 mice maintained under control or long-term (9-month) caloric restriction (Higami et al 2004).…”
Section: Discussionmentioning
confidence: 99%
“…Studies have examined 10-11-month-old male C57BL/6 mice maintained under control or long-term (9-month) caloric restriction (Higami et al 2004). Caloric restriction altered expression of 345 expressed genes (5.5%) by 1.5-fold relative to ad libitum fed controls (Higami et al 2004).…”
Section: Discussionmentioning
confidence: 99%
“…3). Expression of these genes has been reported to be significantly altered by CR (Higami, 2004;Park, 2009).…”
Section: Gene Expression In Wat Associated With Energy Metabolismmentioning
confidence: 99%