Adipose Tissue and Atherothrombosis

Alessi, Marie‐Christine; Lijnen, H. Roger; Bastelica, Delphine; Juhan‐Vague, I.

doi:10.1159/000083816

Cited by 56 publications

(39 citation statements)

References 113 publications

(82 reference statements)

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“…6 Moreover, the demonstration of the reduction of PAI-1 or platelet-derived MPs plasma levels through weight loss paves the way to a possible therapeutic target for controlling cardiovascular morbidity in obese subjects. 7,8 To further characterize the relationship between obesity and the thrombotic risk, we sought to evaluate the impact of a short-term very low-calorie diet (VLCD) on procoagulant MP levels, fibrinolytic status, inflammation and endothelium damage. Given the prime importance of leukocyte shedding in the formation of the thrombus, special attention was paid to the variation of leukocyte-derived MPs levels.…”

Section: Introductionmentioning

confidence: 99%

Short-term very low-calorie diet in obese females improves the haemostatic balance through the reduction of leptin levels, PAI-1 concentrations and a diminished release of platelet and leukocyte-derived microparticles

et al. 2011

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Background: In obesity, metabolic stress and inflammation in injured tissues could favour enhanced shedding of procoagulant microparticles (MPs). At sites of endothelium injury, the swift recruitment of procoagulant leukocyte-derived MPs enables the initiation of blood coagulation and thrombus growth. Objectives: In obese females, we sought to evaluate the impact of a very low-calorie diet (VLCD) on procoagulant MP levels, fibrinolytic status, inflammation and endothelium damage. Methods: Circulating biomarkers of vascular damage, fibrinolytic status, platelet activation and inflammation were measured before, 30 and 90 days after starting a short-term VLCD. MPs were measured by flow cytometry and capture assays. Their procoagulant potential was quantified using functional prothrombinase assays and their cellular origin were determined using flow cytometry (endothelium, platelet, leukocyte, lymphocyte and erythrocyte-derived MP) or capture assays. Results: A total of 24 obese females (39 ± 10 years) with a mean body mass index of 35 ± 4 kg m À2 were prospectively enroled. Procoagulant leukocyte-derived MPs were associated with the waist circumference at baseline (r ¼ 0.534; P ¼ 0.010) and at 90 days follow-up (r ¼ 0.487; P ¼ 0.021). At 90 days, weight reduction (À9.8%) was associated with a lowering of blood pressure, improvement of metabolic parameters and a significant reduction of plasminogen activator inhibitor-1 (PAI-1) (À38%), procoagulant platelet-derived MPs (À43%), leukocyte-derived MPs (À28%) and leptin (À32%) levels. Conclusion: In obese females, a short-term VLCD results in an overall improvement of the haemostatic balance characterized by the reduction of PAI-levels, diminished release of platelet and leukocyte-derived MPs and a reduction in leptin levels, an adipocyte-derived cytokine.

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Section: Introductionmentioning

confidence: 99%

Short-term very low-calorie diet in obese females improves the haemostatic balance through the reduction of leptin levels, PAI-1 concentrations and a diminished release of platelet and leukocyte-derived microparticles

et al. 2011

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“…Obesity is associated with a number of pathological disorders, including non-insulin-dependent diabetes, hypertension, hyperlipidemia, and cardiovascular diseases (1). Adipose tissue biology studies have led to improved understanding of the mechanisms that link obesity to metabolic syndrome and other complications.…”

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confidence: 99%

Ultraviolet A Regulates Adipogenic Differentiation of Human Adipose Tissue-derived Mesenchymal Stem Cells via Up-regulation of Kruppel-like Factor 2

Lee

Jung

et al. 2010

Journal of Biological Chemistry

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Adipocyte dysfunction is strongly associated with the development of obesity, which is a major risk factor for many disorders, including diabetes, hypertension, and heart disease. This study shows that ultraviolet A (UVA) inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells and its action mechanisms. The mRNA levels of peroxidase proliferator-activated receptor (PPAR) ␥ and CCAAT/enhancer -binding protein ␣ (C/EBP␣), but not CCAAT/enhancer-binding protein ((C/EBP) ␤ and ␦, were reduced by UVA. Moreover, the mRNA levels of PPAR ␥ target genes (lipoprotein lipase (LPL), CD36, adipocyte protein (aP2), and liver X receptor ␣ (LXR)) were down-regulated by UVA. Additionally, attempts to elucidate a possible mechanism underlying the UVA-mediated effects revealed that UVA induced migration inhibitory factor (MIF) gene expression, and this was mediated through activation of AP-1 (especially JNK and p42/44 MAPK) and nuclear factor-B. In addition, reduced adipogenesis by UVA was recovered upon the treatment with anti-MIF antibodies. AMP-activated protein kinase phosphorylation and up-regulation of Kruppel-like factor 2 (KLF2) were induced by UVA. Taken together, these findings suggest that the inhibition of adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells by UVA occurs primarily through the reduced expression of PPAR ␥, which is mediated by up-regulation of KLF2 via the activation of MIF-AMP-activated protein kinase signaling.

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“…따라서 이 러한 비만억제를 위하여 세포 내 지방의 축적을 예방하거나 축적된 지방을 분해하도록 자극하는 방안에 대한 연구가 최근 많은 관심을 끌고 있다. 일반적으로 비만은 지방전구세포의 분화와 같은 adipogenesis (지방세포 분화) 과정을 통하여 새 롭게 생성되는 지방세포의 비대 및 과형성에 의한 지방조직의 축적에 의하여 유발되는 것으로 알려져 있다 [1,6]. 지방세포의 비대는 음식물에 포함되어 있는 triglyceride의 축적에 의하여 유발되며, 지방세포의 과형성은 세포증식 및 분화에 의해서 유발되는 것으로 알려져 있다 [15].…”

Section: 서 론unclassified

Effects of Hizikia fusiforme Extracts on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes

Choi¹,

Kim²,

Han³

et al. 2012

Journal of Life Science

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The present study was conducted to evaluate the effects of various extracts of Hizikia fusiforme on the anti-obesity effects in 3T3-L1 preadipocytes. We used H. fusiforme extracts from ethanol (EEHF), dichloromethane (CFHF), ethyl acetate (EAFHF), butanol (BFHF), and water (WFHF). Treatment with these extracts significantly suppressed terminal differentiation of 3T3-L1 preadipocytes in a dose-dependent manner as confirmed by a decrease in lipid droplet content through Oil Red O staining; this effect was higher in WFHF than in other extracts. The concentrations of cellular triglyceride were also reduced in 3T3-L1 cells by exposure with these extracts, especially when compared with the controls. Treatment with 200 μg/ml of WFHF and CFHF caused approximately 42.6% and 23.7% reduction, respectively. In addition, the extracts of H. fusiforme significantly reduced the expression levels of key pro-adipogenic transcription factors, including peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding proteins α (C/EBPα) and C/EBPβ as compared with controls. Accordingly, our data indicated that WFHF has a preeminent effect on inhibition of adipocyte differentiation among various extracts, and H. fusiforme extracts may be an ideal candidate for obesity relief.

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Adipose Tissue and Atherothrombosis

Cited by 56 publications

References 113 publications

Short-term very low-calorie diet in obese females improves the haemostatic balance through the reduction of leptin levels, PAI-1 concentrations and a diminished release of platelet and leukocyte-derived microparticles

Short-term very low-calorie diet in obese females improves the haemostatic balance through the reduction of leptin levels, PAI-1 concentrations and a diminished release of platelet and leukocyte-derived microparticles

Ultraviolet A Regulates Adipogenic Differentiation of Human Adipose Tissue-derived Mesenchymal Stem Cells via Up-regulation of Kruppel-like Factor 2

Effects of Hizikia fusiforme Extracts on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes

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