Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity

Wang, Hongdong; Shen, Lei; Sun, Xu; Liu, Fangcen; Feng, Wenhuan; Jiang, Chunping; Chu, Xuehui; Xiao, Ye; Jiang, Can; Wang, Yan; Zhang, Pengzi; Zang, Mengwei; Zhu, Dalong; Bi, Yan

doi:10.1038/s41467-019-11270-1

Cited by 83 publications

(71 citation statements)

References 34 publications

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“…Higher numbers of circulating and adipose ILC1-like cells expressing IFN-γ have also been detected in obese subjects. Numbers of adipose ILC1-like cells are further increased in obese subjects with type 2 diabetes and correlate with insulin resistance [107]. A caveat with this hypothesis is that the genetic ablation tools to definitively differentiate between the contribution of each subset of group 1 ILCs to obesity-associated insulin resistance do not currently exist, and current flow cytometry-based strategies to identify human ILC1s are not specific [9].…”

Section: Ilc Activation Disrupts Metabolic Homeostasis During Diet-inmentioning

confidence: 99%

RETRACTED: Living with Yourself: Innate Lymphoid Cell Immunometabolism

Rolot

O’Sullivan

2020

Cells

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Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activating signals become dysregulated. Recent work has demonstrated that the crosstalk between ILCs and their environment has a significant impact on host metabolism in health and disease. In this review, we summarize studies that support evidence for the ability of ILCs to influence tissue and systemic metabolism, as well as how ILCs can be regulated by environmental changes in systemic host metabolism. We also highlight studies demonstrating how ILC- intrinsic metabolism influences their activation, proliferation, and homeostasis. Finally, this review discusses the challenges and open questions in the rapidly expanding field of ILCs and immunometabolism.

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Section: Ilc Activation Disrupts Metabolic Homeostasis During Diet-inmentioning

confidence: 99%

RETRACTED: Living with Yourself: Innate Lymphoid Cell Immunometabolism

Rolot

O’Sullivan

2020

Cells

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“…In T2DM, the numbers of circulating as well as adipose tissue-resident ILC1s are increased compared with normal individuals (184,185). The frequency of circulating ILC1s is positively correlated with fasting plasma glucose (FPG), HbA1c, homeostasis model assessment for insulin resistance (HOMA-IR), serum-free fatty acids (FFAs) and adipose tissue insulin resistance index (Adipo-IR) (184,185). It has also been shown that patients with increased numbers of ILC1 have an elevated risk of developing T2DM (184).…”

Section: Innate Lymphoid Cells (Ilcs)mentioning

confidence: 99%

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

et al. 2020

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Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM). The field of immunometabolism implies a bidirectional link between the immune system and metabolism, in which inflammation plays an essential role in the promotion of metabolic abnormalities (e.g., obesity and T2DM), and metabolic factors, in turn, regulate immune cell functions. Obesity as the main inducer of a systemic low-level inflammation is a main susceptibility factor for T2DM. Obesity-related immune cell infiltration, inflammation, and increased oxidative stress promote metabolic impairments in the insulin-sensitive tissues and finally, insulin resistance, organ failure, and premature aging occur. Hyperglycemia and the subsequent inflammation are the main causes of micro-and macroangiopathies in the circulatory system. They also promote the gut microbiota dysbiosis, increased intestinal permeability, and fatty liver disease. The impaired immune system together with metabolic imbalance also increases the susceptibility of patients to several pathogenic agents such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus, the need for a proper immunization protocol among such patients is granted. The focus of the current review is to explore metabolic and immunological abnormalities affecting several organs of T2DM patients and explain the mechanisms, whereby diabetic patients become more susceptible to infectious diseases.

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“…Moreover, obesity could drive the secretion of IL-15 by adipose tissue macrophages, which has been demonstrated to have a positive effect on NK cell metabolism, proliferation and activation ( 84 ). In addition to NK cells, it is recently found that IL-12 activation of ILC1s is also implicated in driving obesity-associated adipose tissue inflammation ( 85 , 86 ). In summary, these studies suggest that obesity leads to the overaction of adipose NK cells, but loss of function of peripheral NK cells, which further contributes to obesity-related pathology and attenuated immunosurveillance, respectively.…”

Section: Nk Cell Metabolism In Diseasementioning

confidence: 99%

Metabolism of Natural Killer Cells and Other Innate Lymphoid Cells

Cong

2020

Front. Immunol.

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Natural killer (NK) cells are the host's first line of defense against tumors and viral infections without prior sensitization. It is increasingly accepted that NK cells belong to the innate lymphoid cell (ILC) family. Other ILCs, comprising ILC1s, ILC2s, ILC3s and lymphoid tissue inducer (LTi) cells, are largely non-cytotoxic, tissue-resident cells, which function to protect local microenvironments against tissue insults and maintain homeostasis. Recently, evidence has accumulated that metabolism supports many aspects of the biology of NK cells and other ILCs, and that metabolic reprogramming regulates their development and function. Here, we outline the current understanding of ILC metabolism, and describe how metabolic processes are affected, and how metabolic defects are coupled to dysfunction of ILCs, in disease settings. Furthermore, we summarize the current and potential directions for immunotherapy involving targeting of ILC metabolism. Finally, we discuss the open questions in the rapidly expanding field of ILC metabolism.

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Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity

Cited by 83 publications

References 34 publications

RETRACTED: Living with Yourself: Innate Lymphoid Cell Immunometabolism

RETRACTED: Living with Yourself: Innate Lymphoid Cell Immunometabolism

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

Metabolism of Natural Killer Cells and Other Innate Lymphoid Cells

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