Adipose Derived Stem Cells Protect Skin Flaps Against Ischemia-Reperfusion Injury

Reichenberger, M; Heimer, Sina; Schaefer, Amelia; Laß, Ulrike; Gebhard, Martha Maria; Germann, Günter; Leimer, Uwe; Köllensperger, Eva; Mueller, Wolf

doi:10.1007/s12015-012-9368-5

Cited by 56 publications

(45 citation statements)

References 31 publications

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“…It was found that stem cell treatment significantly enhances skin flap survival in the aftermath of ischemia, to an extent that almost equals surgical results without ischemia. This effect is accompanied by a pronounced and significant angiogenic response and improved blood perfusion [28]. If these results can be confirmed by other studies, they will mark substantial progress in microsurgical reconstruction surgery.…”

Section: The Use Of Selected Sc Fractions In Plastic and Reconstructisupporting

confidence: 54%

The Use of Stem Cells in Plastic and Reconstructive Surgery

Koźlik

Wójcicki

2014

Adv Clin Exp Med

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As part of their clinical practice, plastic surgeons perform procedures in the fields of skin and adipose tissue grafting, the reconstruction of compound tissue loss and congenital malformations, the treatment of acute and chronic wounds and burns, as well as cosmetic surgery. On account of the great expectations associated with their use in therapy, stem cells (SCs) are increasingly frequently employed in in vitro experiments, animal models and clinical trials. The most commonly utilized SCs for these purposes are adult stem cells (AS), which are present in small amounts in every tissue; among these are two types of cells: bone marrow mesenchymal stem cells (BM-MSCs) and adipose-derived stem cells (ADSCs). The aim of this review is to present current findings in experimental research on the use of stem cells in the field of plastic and reconstructive surgery. Many studies have described the progress of trials using ADSCs and BM-MSCs mainly in the treatment of compound tissue loss and chronic wounds. The use of their paracrine, proangiogenic and osteogenic functions is emphasized. However, because of the very high harvesting and culturing expenses and the limited availability of data on their safety for human use, SCs are not a first-choice therapy. Further developments in SC research and gradually decreasing costs mean that along with commercial-scale SC culturing, the use of SCs will become a viable alternative to traditional surgical procedures (Adv Clin Exp Med 2014, 23, 6, 1011-1017).

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Section: The Use Of Selected Sc Fractions In Plastic and Reconstructisupporting

confidence: 54%

The Use of Stem Cells in Plastic and Reconstructive Surgery

Koźlik

Wójcicki

2014

Adv Clin Exp Med

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“…Cells at P4, which still possessed multipotent differentiation potential (Figure 2), were used for transplantation in this study. Compared with similar studies, the number of cells injected in this study was higher than others [8,[30][31][32][33]. Despite this, cells expanded at passage 6 could increase the number of cells for injection, but did not improve the protective effects in skin flap survival (data not shown).…”

Section: Discussioncontrasting

confidence: 79%

Comparison of Bone Marrow-derived Mononuclear Cells vs. Mesenchymal Stem Cells in Protecting Random-pattern Skin Flap Survival in Rats

Xu¹,

Yang²

2016

J Stem Cell Res Ther

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“…Although the mean survival area ratios in the ADSCs treatment group and in the BMSCs treatment group had no significant difference, higher levels of bFGF and VEGF were found in the BMSCs transplantation group [21] . In addition, ADSCs also had a significantly angiogenic response [22] , better immune compatibility and potential for enhancing the blood supply. These together suggest that both ADSCs and BMSCs have proangiogenic effect, but their promoting angiogenesis mechanisms may be quite different.…”

Section: Mscs Therapy Against Pedicle Flaps Necrosismentioning

confidence: 99%

New advances in the mesenchymal stem cells therapy against skin flaps necrosis

Zhang¹

2014

WJSC

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Mesenchymal stem cells (MSCs), multipotential cells that reside within the bone marrow, can be induced to differentiate into various cells, such as osteoblasts, adipocytes, chondrocytes, vascular endothelial progenitor cells, and other cell types. MSCs are being widely studied as potential cell therapy agents due to their angiogenic properties, which have been well established by in vitro and in vivo researches. Within this context, MSCs therapy appears to hold substantial promise, particularly in the treatment of conditions involving skin grafts, pedicle flaps, as well as free flaps described in literatures. The purpose of this review is to report the new advances and mechanisms underlying MSCs therapy against skin flaps necrosis.

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Adipose Derived Stem Cells Protect Skin Flaps Against Ischemia-Reperfusion Injury

Cited by 56 publications

References 31 publications

The Use of Stem Cells in Plastic and Reconstructive Surgery

The Use of Stem Cells in Plastic and Reconstructive Surgery

Comparison of Bone Marrow-derived Mononuclear Cells vs. Mesenchymal Stem Cells in Protecting Random-pattern Skin Flap Survival in Rats

New advances in the mesenchymal stem cells therapy against skin flaps necrosis

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