ADIPOQ rs2241766 SNP as protective marker against DIBC development in Mexican population

Abstract

BackgroundAdiponectin protein and some variations in its gene, ADIPOQ have recently been associated with cancer because they regulate glucose and lipid metabolism as well as anti-apoptotic and anti-inflammatory proteins.AimThe aim of this study was to analyse the relationship between selected biochemical markers, anthropometric indices and ADIPOQ rs2241766 and rs1501299 SNPs in ductal infiltrating breast cancer (DIBC) in a Mexican population.MethodsThis cross-sectional study included 64 DIBC patients and 167 healthy women. Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) analysis was performed to identify the genotypes of the rs2241766 (exon 2) and rs1501299 (intron 2) ADIPOQ polymorphisms. Corporal composition and biochemical markers included body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR), glucose, cholesterol, triglycerides and high- and low-density lipoprotein cholesterol.ResultsPatients with DIBC had higher serum glucose, WC and WHR than controls. Intergroup differences in allele and genotype frequencies were found for both polymorphisms (P < 0.05). Patients carrying the rs2241766 TT and TG genotypes had higher values of WC, HC and WHR, but only TG carriers had higher levels of glucose. For the SNP rs1501299, carriers of the GG genotype in the DIBC group had higher values of glucose, WC, HC and WHR than the respective control group.ConclusionsThese results suggest that WC, HC and WHR are better predictors of DIBC than BMI. The ADIPOQ SNP rs2241766 emerges as a protective factor, whereas rs1501299 is a risk factor for DIBC development in a Mexican population.

Excavation of Genes Related to the Mining of Growth, Development, and Meat Quality of Two Crossbred Sheep Populations Based on Comparative Transcriptomes

“…IGF-1 and IGF-2, both endocrine hormones, are responsible for the growth and development of muscles and bones [ 29 ]. ADIPOQ is involved in the regulation of glucose and lipid metabolism and anti-apoptosis, and is directly involved in the growth and development process [ 30 ]. Glycan (GPC) is a membrane proteoglycan containing a glucose-6-phosphate isomerase (GPI) anchor.…”

“…Glutathione peroxidase 1(GPX1) also plays an important role in regulating the growth and development of muscles and has a high expression in muscle tissues [ 35 ]. In summary, through a review of the literature, it was found that the roles of eight key genes in 13 co-expressed genes in growth, development, and meat quality have been confirmed, including PPARD [ 27 ], IGF1 [ 29 ], ADIPOQ [ 30 ], GPC1 [ 31 ], FGFRL1 [ 32 ], SIX1 [ 33 ], MYL2 [ 34 ], and GPX1 [ 35 ]. The role of five genes ( LARGE , CRYAB , LOC10110646 , PLCB1 and CDC42 ) in growth, development, and meat quality has not been extensively studied, and they can be used as candidate genes for further research.…”

ADIPOQ single nucleotide polymorphisms and breast cancer in northeastern Mexican women

“…Another study reports no association between ADIPOQ SNPs and BC in American white women [ 25 ]. Genotypes TG and GG of SNP rs2241766 have also been associated with a decreased risk for BC when compared to the TT genotype, the rs2241766 variation with the G allele and the TG and TG + GG genotypes may have a protective effect in ductal infiltrating breast cancer in Mexican women [ 26 ].…”

<p>Polymorphism Of The <em>APM1</em> Gene In Subjects With Central Obesity Related To Lower High-Density Lipoprotein Cholesterol</p>

“…These variations are also correlated with cancer because of its function in glucose and lipid metabolism. In a Mexican population with ductal infiltrating breast cancer (DIBC), patients with the TT and GT genotypes of the APM1 SNP (rs2241766) showed higher values of WC, hip circumference (HP), and waist-hip ratio (WHR) 58…”