Adiponectin Isoforms and Leptin Impact on Rheumatoid Adipose Mesenchymal Stem Cells Function

Skalska, Urszula; Kontny, Ewa

doi:10.1155/2016/6532860

Cited by 12 publications

(15 citation statements)

References 18 publications

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“…This means that HMW both triggers inflammation and stimulates the release of IL-6 and IL-8, which is associated with pro-destructive effects in RA FLS [127]. The secretion of TGFβ, IL-6, IL-1Ra, PGE 2 , IL-8, and VEGF was considerably increased in HMW-treated RA-adipose mesenchymal stem cells but not in LMW-treated cells [128]. Furthermore, the ratio of three full-length adiponectin isoforms was compared in the serum of RA patients.…”

Section: Issues Related To Hmw: Pro-inflammatory or Anti-inflammatorymentioning

confidence: 94%

Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases

Choi

Doss

Kim

2020

IJMS

279

231

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Adiponectin is the richest adipokine in human plasma, and it is mainly secreted from white adipose tissue. Adiponectin circulates in blood as high-molecular, middle-molecular, and low-molecular weight isoforms. Numerous studies have demonstrated its insulin-sensitizing, anti-atherogenic, and anti-inflammatory effects. Additionally, decreased serum levels of adiponectin is associated with chronic inflammation of metabolic disorders including Type 2 diabetes, obesity, and atherosclerosis. However, recent studies showed that adiponectin could have pro-inflammatory roles in patients with autoimmune diseases. In particular, its high serum level was positively associated with inflammation severity and pathological progression in rheumatoid arthritis, chronic kidney disease, and inflammatory bowel disease. Thus, adiponectin seems to have both pro-inflammatory and anti-inflammatory effects. This indirectly indicates that adiponectin has different physiological roles according to an isoform and effector tissue. Knowledge on the specific functions of isoforms would help develop potential anti-inflammatory therapeutics to target specific adiponectin isoforms against metabolic disorders and autoimmune diseases. This review summarizes the current roles of adiponectin in metabolic disorders and autoimmune diseases.

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Section: Issues Related To Hmw: Pro-inflammatory or Anti-inflammatorymentioning

confidence: 94%

Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases

Choi

Doss

Kim

2020

IJMS

279

231

View full text Add to dashboard Cite

show abstract

“…[17] Thus, leptin levels may be a risk factor for the pathogenesis of RA [18]. Olama et al (2012) [15] evaluated the ratio of synovial and serum leptin in patients with RA and found that the local utilization of leptin at the joint cavity has a Records identified through database searching (n = 38)…”

Section: Leptinmentioning

confidence: 99%

“…However, this association was not mediated by the selective effect of HMW adiponectin. [69] Recently, Skalska and Kontny (2016) [18] observed that HMW and MMW adiponectins potentially stimulated the secretion of rheumatoid ASC (adipose-derived stem cells) in patients with RA, but did not exert a strong impact on ASC towards RA-FLS (fibroblast-like synoviocytes) and peripheral blood mononuclear cells. Furthermore, Rho et al (2010) [19] did not find any association between adiponectin levels and insulin resistance or coronary artery calcium score.…”

Section: Mirfeizi Et Al (2014) [30]mentioning

confidence: 99%

Adipokines in rheumatoid arthritis

et al. 2018

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Rheumatoid arthritis affects millions of people worldwide and is considered a chronic multisystem disease whose causes are unknown. In general, the main objective of rheumatoid arthritis treatment is to improve the quality of life of patients by relieving pain, maintaining or improving functional capacity, preventing thus, disability. In recent years the role of adipokines in the pathogenesis of rheumatoid arthritis has been discussed but results are still conflicting. Although results from some studies have shown the implications of adipokines in the pathophysiology of autoimmune diseases, including rheumatoid arthritis, their role in the pathogenesis of disease progression is not clear. Thus, this review aimed to describe the association of key adipokines (leptin, resistin, visfatin and adiponectin) and rheumatoid arthritis, given the high prevalence of this disease and the important social impact caused by this chronic disabling disease.

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“…Adiponectin aggravated bone erosions by promoting osteopontin production in RA synovial tissue, suggesting that adiponectin induced the expression of osteopontin, which in turn recruited osteoclasts [58]. Recently, the effects of adiponectin were assessed on adipose mesenchymal stem cells (ASCs) derived from the infrapatellar fat pad of RA patients [59]. ASCs were stimulated with both low molecular weight (LMW) and high/middle molecular weight (HMW/MMW) adiponectin isoforms.…”

Section: Adipocytokines In Ra: Generality Pathogenic Mechanisms mentioning

confidence: 99%

“…The authors observed that the secretion of proinflammatory mediators was upregulated by HMW/MMW adiponectin, but not by LMW adiponectin. In addition, they observed that the stimulation with HMW/MMW adiponectin reduced the proproliferative effects of ASC-derived soluble factors on RA synovial fibroblasts [59]. Taking together these results, it is possible to suggest a proinflammatory and joint destructive role of adiponectin in RA [55–59].…”

Section: Adipocytokines In Ra: Generality Pathogenic Mechanisms mentioning

confidence: 99%

Adipocytokines in Rheumatoid Arthritis: The Hidden Link between Inflammation and Cardiometabolic Comorbidities

Ruscitti

Benedetto

Berardicurti

et al. 2018

Journal of Immunology Research

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Rheumatoid arthritis is a chronic autoimmune disease affecting typically synovial joints and leading to progressive articular damage, disability, and reduced quality of life. Despite better recent therapeutic strategies improving long-term outcomes, RA is associated with a high rate of comorbidities, infections, malignancies, and cardiovascular disease (CVD). Remarkably, some well-known pathogenic proinflammatory mediators in RA, such as interleukin-1β (IL-1β) and tumor necrosis factor (TNF), may play a pivotal role in the development of CVD. Interestingly, different preclinical and clinical studies have suggested that biologic agents commonly used to treat RA patients may be effective in improving CVD. In this context, the contribution of adipocytokines has been suggested. Adipocytokines are pleiotropic molecules, mainly released by white adipose tissue and immune cells. Adipocytokines modulate the function of different tissues and cells, and in addition to energy homeostasis and metabolism, amplify inflammation, immune response, and tissue damage. Adipocytokines may contribute to the proinflammatory state in RA patients and development of bone damage. Furthermore, they could be associated with the occurrence of CVD. In this study, we reviewed available evidence about adipocytokines in RA, because of their involvement in disease activity, associated CVD, and possible biomarkers of prognosis and treatment outcome and because of their potential as a possible new therapeutic target.

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Adiponectin Isoforms and Leptin Impact on Rheumatoid Adipose Mesenchymal Stem Cells Function

Cited by 12 publications

References 18 publications

Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases

Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases

Adipokines in rheumatoid arthritis

Adipocytokines in Rheumatoid Arthritis: The Hidden Link between Inflammation and Cardiometabolic Comorbidities

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