Adiponectin gene expression in subcutaneous and deep neck adipose tissue

Jakšić, Vlatka Pandžić; Grizelj, Danijela; Marušić, Maruška; Boscic, Drago; Ozegovic, Ivan; Vlasic, Ana; Ajduk, Marko; Pavić, Predrag; Šubarić, Marin; Kušec, Rajko; Jakšić, Ozren

doi:10.1530/endoabs.35.p785

Cited by 2 publications

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“…Our previous results suggested significantly lower adiponectin gene expression in pericarotid than in subcutaneous NAT, but in females without advanced atherosclerotic disease. 66 The current analysis was performed in men who typically have less SAT, less adiponectin, and are more prone to atherosclerosis development. 4 In fact, adiponectin gene expression signal might also divert as in recent reports from patients undergoing endarterectomy that found a paradoxically elevated pericarotid adiponectin expression.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Gene Expression in Neck Perivascular and Subcutaneous Adipose Tissue in Men With Carotid Stenosis

et al. 2021

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The inflammatory phenotype of neck adipose tissue (NAT) might reflect its involvement in the pathogenesis of carotid atherosclerosis. We investigated inflammatory gene expression in the subcutaneous and the perivascular (pericarotid) adipose tissue from patients with carotid stenosis (CS) undergoing endarterectomy and a control group of patients without significant carotid atherosclerosis undergoing thyroid surgery. Only male patients were included (n = 13 in each study group). Clinical and biochemical data along with serum leptin, adiponectin, and monocyte chemoattractant protein 1 (MCP-1) were collected. Adipose tissue samples were obtained from both the subcutaneous and pericarotid compartments. Real-time polymerase chain reaction was used to measure gene expression of macrophage markers and adipokines. The CS group had higher subcutaneous and pericarotid visfatin gene expression and higher pericarotid expression of MCP-1 and CD68 genes. The ratio between pericarotid CD206 and CD68 gene expression was similar between study groups. Adiponectin gene expression in both NAT compartments did not differ between groups, but it was negatively associated with body weight. These observations suggest that NAT, and especially the pericarotid compartment, express enhanced inflammatory properties in patients with CS, but the proportion of anti-inflammatory macrophages in advanced atherosclerosis seems to be maintained.

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Section: Discussionmentioning

confidence: 99%

Inflammatory Gene Expression in Neck Perivascular and Subcutaneous Adipose Tissue in Men With Carotid Stenosis

et al. 2021

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Neck adipose tissue – tying ties in metabolic disorders

Jakšić

Grizelj

Livun

et al. 2018

Hormone Molecular Biology and Clinical Investigation

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Upper body adipose tissue accumulation has been associated with clustering of metabolic disorders and increased cardiovascular risk. Neck circumference (NC) indicated that subcutaneous adipose tissue (SAT) in that region is an independent pathogenic depot that might account for the additional risk missed by visceral adipose tissue (VAT). Neck adipose tissue (NAT) is not only one more ectopic depot but has several particular features that might modulate its metabolic role. Besides a controversial impact on obstructive apnea syndrome, neck fat encompasses carotid arteries as an important perivascular adipose tissue (PVAT) depot. With dysfunctional changes in obesity, physiologic vascular regulation is lost and inflammatory signals accelerate atherogenesis. Unexpected was the discovery of brown and beige adipocytes in the neck of human adults. When stimulated, brown adipose tissue (BAT) dissipates energy through thermogenesis and it is associated with other favorable metabolic effects. Moreover, the neck is the region where the browning mechanism was disclosed. With this unique plastic nature, NAT revealed multiple ties, challenging dynamics and potential new therapeutic targets that might have significant implications on metabolic outcomes and vascular risk.

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Adiponectin gene expression in subcutaneous and deep neck adipose tissue

Cited by 2 publications

References 0 publications

Inflammatory Gene Expression in Neck Perivascular and Subcutaneous Adipose Tissue in Men With Carotid Stenosis

Inflammatory Gene Expression in Neck Perivascular and Subcutaneous Adipose Tissue in Men With Carotid Stenosis

Neck adipose tissue – tying ties in metabolic disorders

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