2017
DOI: 10.14814/phy2.13523
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Abstract: Adiponectin (APN) is a multifunctional adipocytokine that inhibits myocardial fibrosis, dilatation, and left ventricular (LV) dysfunction after myocardial infarction (MI). Coxsackievirus B3 (CVB3) myocarditis is associated with intense extracellular matrix (ECM) remodeling which might progress to dilated cardiomyopathy. Here, we investigated in experimental CVB3 myocarditis whether APN inhibits adverse ECM remodeling following cardiac injury by affecting matrix metalloproteinase (MMP) expression. Cardiac injur… Show more

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Cited by 16 publications
(10 citation statements)
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“…Significant progress has been made to elucidate molecular mechanisms related to liver fibrosis, and we now have a far better understanding of liver myofibroblast biology. While the anti-fibrotic properties of adiponectin have been well-characterized in preclinical settings [6,7,42,43], recombinant adiponectin therapy is not practical to administer to humans. Here, we investigated the potential role of adiponectin as an activator of PTEN expression that could reverse hepatic fibrosis.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Significant progress has been made to elucidate molecular mechanisms related to liver fibrosis, and we now have a far better understanding of liver myofibroblast biology. While the anti-fibrotic properties of adiponectin have been well-characterized in preclinical settings [6,7,42,43], recombinant adiponectin therapy is not practical to administer to humans. Here, we investigated the potential role of adiponectin as an activator of PTEN expression that could reverse hepatic fibrosis.…”
Section: Discussionmentioning
confidence: 99%
“…When activated, HSCs transdifferentiate into α-smooth muscle actin (α-SMA) expressing myofibroblast-like cells, which are the major matrix-producing cells involved in hepatic fibrosis [1]. We and others have recently demonstrated that adiponectin, a 30 kDa adipocytokine primarily secreted by white adipose tissue (WAT), has anti-fibrotic properties both in vivo and in vitro [610]. Adiponectin signaling occurs via its two cognate receptors: adiponectin receptor 1 and 2 [11,12].…”
Section: Introductionmentioning
confidence: 99%
“…While the degradation of collagen fibers found in the ECM will stiffen the heart and reduce its elasticity further worsening the ability to contract. 83 At the cellular level, pathogens have been demonstrated to activate different cell death pathways including apoptosis, 84 necrosis, pyroptosis, 85,86 and necroptosis 87 resulting in decreased viability. Whether a cause or effect, activation of different cell death pathways are proposed to be involved in the pathogenesis of FM, even myocardium necrosis has been observed in EMB samples.…”
Section: Pathophysiological Mechanisms Underlying Fmmentioning
confidence: 99%
“…Similarly, elevated concentration of IL-10, IL-6, IL-1β and decreased concentration of IL-1ra in blood plasma might be markers of a fructose-induced systemic inflammatory state. Finally, high concentration of leptin and adiponectin in BALF of fructose-exposed mice might have a connection with accumulation of collagen in the alveolar septa as both have been reported to modulate the remodeling of extracellular matrix in cardiovascular tissues 27,28 .…”
Section: Discussionmentioning
confidence: 97%