Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver

Matsuura, Fumihiko; Oku, Hiroyuki; Koseki, Masahiro; Sandoval, Jose C.; Yuasa-Kawase, Miyako; Tsubakio-Yamamoto, Kazumi; Masuda, Daisuke; Maeda, Norikazu; Tsujii, K.; Ishigami, Masato; Nishida, Makoto; Hirano, Ken‐ichi; Kihara, Shinji; Hori, Masatsugu; Shimomura, Iichiro; Yamashita, Shizuya

doi:10.1016/j.bbrc.2007.05.040

Cited by 126 publications

(74 citation statements)

References 19 publications

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“…The adiponectin receptors respond differently to the various forms of adiponectin, which are primarily either full length or globular (i.e., fAdpn or gAdpn) [32]. Adiponectin has been shown to regulate inflammation and protect against atherogenesis by antagonizing the pro-inflammatory effects of tumor necrosis factor-α [14,[33][34][35][36][37]. Due to C1q-like, collagenous domains, fAdpn monomers can aggregate into multimers of low, medium, and high (HMW) molecular weight forms, with the HMW form accounting for half of total adiponectin in normal individuals [32,[38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Adiponectin Receptor-1 C-Terminal Fragment (CTF) in Plasma: Putative Biomarker for Diabetes

et al. 2009

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Introduction Polypeptide fragments from cell surface receptors when found in plasma may be indicators of receptor regulation in disease conditions. It is known that subjects with diabetes have significantly lower plasma concentrations of adiponectin, a hormone released by adipose tissue, compared with nondiabetic controls. This hormone interacts with cell surface receptors in muscle (AdipoR1) and liver (AdipoR2). Methods We analyzed the relative distribution of specific fragments of AdipoR1 in healthy and diabetic individuals using an immunoaffinity mass spectrometry approach. We used antibodies raised against AdipoR1 immobilized on pre-activated protein chip surfaces to determine the molecular weights of bound polypeptide fragments using immunomass spectrometry (immuno-MS). Results Initially, immuno-MS analyses using a polyclonal antibody revealed two peaks (m/z 3,902 and 7,812) in plasma from normal, healthy individuals (n=5) that were not present in the plasma of diabetics (n=5). To confirm the detection of these fragments, a monoclonal antibody was developed against the last 25 amino acids of the AdipoR1 C-terminal fragment (CTF). Using the immuno-MS method, the monoclonal antibody detected the AdipoR1 CTF (m/z 3475) in all healthy controls (n=10), but did not detect these fragments in the diabetic patients (n=10). Discussion These preliminary observations suggest that the plasma levels of this receptor fragment may serve as an indicator of diabetic condition.

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Section: Discussionmentioning

confidence: 99%

Adiponectin Receptor-1 C-Terminal Fragment (CTF) in Plasma: Putative Biomarker for Diabetes

et al. 2009

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“…Adiponectin levels correlate positively with HDL-C levels 76) . Adiponectin promotes HDL production via ApoA-I production and increased ABCA1 expression in the liver 77,78) , and also in macrophages to activate RCT 79) . Pitavastatin and pravastatin elevate adiponectin expression in adipocytes 80) .…”

Section: Other Factors Involved In Rct 1) Adiponectinmentioning

confidence: 99%

Molecular Mechanisms of HDL-Cholesterol Elevation by Statins and Its Effects on HDL Functions

Yamashita

Tsubakio-Yamamoto

Ohama

et al. 2010

JAT

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“…8 Adiponectin may protect against atherosclerosis by increasing HDL assembly through enhancing ABCA1-mediated cholesterol efflux and apoAI synthesis in the liver. [9][10] Concerning macrophage RCT, in vitro experiments have shown that adiponectin can upregulate the expression of ABCA1 and cholesterol efflux from human macrophages. [11][12] In adiponectin knockout mice, the expression of ABCA1 and cholesterol efflux from macrophages is decreased compared with wild-type mice.…”

Section: Introductionmentioning

confidence: 99%

The expression of ATP-binding cassette transporter A1 in Chinese overweight and obese patients

Zhou

Wang

et al. 2009

Int J Obes

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Background: ATP-binding cassette transporters (ABCA1, ABCG1) and scavenger receptor class B type I (SR-BI) are the three most important cellular cholesterol transporters/receptor in regulating cholesterol efflux. We have investigated whether the expression of these transporters/receptor is altered in overweight and obese patients, and the potential association with the circulating adipokines. Methods: Adiponectin, leptin and resistin were assayed in two groups of healthy controls, overweight and obese patients. The expression of ABCA1, ABCG1 and SR-BI in monocytes was measured. Cholesterol efflux from monocyte-derived macrophages was also determined. Results: Circulating adiponectin was decreased, whereas leptin and resistin were increased in overweight and obese patients compared with healthy controls. ABCA1 expression was significantly decreased in overweight and obese patients (Po0.01), whereas the levels of ABCG1 and SR-BI were comparable between the two groups. Adiponectin was correlated with ABCA1 (r ¼ 0.44, Po0.001), but not with ABCG1 and SR-BI. No associations between leptin, resistin and the expression of ABCA1, ABCG1 and SR-BI were found. Cholesterol efflux from monocyte-derived macrophages to apolipoprotein AI or to autologous serum was significantly impaired in overweight and obese patients, which were correlated with ABCA1 expression (r ¼ 0.47, Po0.001; r ¼ 0.43, Po0.001, respectively). Conclusion: The expression of ABCA1 in monocytes is reduced in overweight and obese patients, and the reduction in ABCA1 is associated with the impairment of cholesterol efflux from monocyte-derived macrophages.

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Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver

Cited by 126 publications

References 19 publications

Adiponectin Receptor-1 C-Terminal Fragment (CTF) in Plasma: Putative Biomarker for Diabetes

Adiponectin Receptor-1 C-Terminal Fragment (CTF) in Plasma: Putative Biomarker for Diabetes

Molecular Mechanisms of HDL-Cholesterol Elevation by Statins and Its Effects on HDL Functions

The expression of ATP-binding cassette transporter A1 in Chinese overweight and obese patients

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