Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

Pan, Yong; Hui, Xiaoyan; Hoo, Ruby L.C.; Ye, Dewei; Chan, Cyrus Yuk Cheung; Feng, Tianshi; Wang, Yudong; Lam, Karen Siu Ling; Xu, Aimin

doi:10.1172/jci123069

Cited by 325 publications

(293 citation statements)

References 69 publications

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“…24 Macrophage KLF4 determined the plasticity of adipose tissue resident macrophages and systemic inflammation in obese mice. 13 More importantly, studies also found KLF4 functioned as a suppressor of renal fibrogenesis. 15,16 Endothelial KLF4 exhibited protection against ischaemic acute kidney injury.…”

Section: Discussionmentioning

confidence: 99%

“…13,24 Therefore, present study further explored the effects of renal KLF4 in obesity-related nephropathy. 13,24 Therefore, present study further explored the effects of renal KLF4 in obesity-related nephropathy.…”

Section: Overexpression Of Klf4 Improves High-fat Diet-induced Renamentioning

confidence: 99%

“…Several studies have shown KLF4 is critical mediator of obesity-related complications, including cardiomyopathy, systemic inflammation and metabolic syndromes. 13,24 Therefore, present study further explored the effects of renal KLF4 in obesity-related nephropathy. Macrophage infiltration is one important character of obesity-related nephropathy.…”

Section: Overexpression Of Klf4 Improves High-fat Diet-induced Renamentioning

confidence: 99%

“…For examples, Mallipattu et al 10 found KLF6 was critical for maintaining renal mitochondrial function and decreasing podocyte death. [12][13][14] Xiao et al and Chen et al found KLF4 functioned as a suppressor of renal fibrogenesis. 11 Another widely studied member of KLFs is KLF4, which transcriptionally activating or repressing the expression of multiple genes.…”

mentioning

confidence: 99%

“…11 Another widely studied member of KLFs is KLF4, which transcriptionally activating or repressing the expression of multiple genes. [12][13][14] Xiao et al and Chen et al found KLF4 functioned as a suppressor of renal fibrogenesis. 15,16 KLF4 also determined the pharmacological benefits in renin-angiotensin blockade-mediated reduction in proteinuria.…”

mentioning

confidence: 99%

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Kruppel‐like factor 4 improves obesity‐related nephropathy through increasing mitochondrial biogenesis and activities

Jin

Pan

et al. 2019

J Cellular Molecular Medi

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Obesity is positively linked to multiple metabolic complications including renal diseases. Several studies have demonstrated Kruppel‐like factor 4 (KLF4) participated in renal dysfunction and structural disorders in acute kidney injuries, but whether it affected the process of chronic kidney diseases was unknown. Therefore, present study was to disclose the role of renal KLF4 in dietary‐induced renal injuries and underlying mechanisms in obesity. Through utilizing high‐fat diet‐fed mice and human renal biopsies, we provided the physiological roles of KLF4 in protecting against obesity‐related nephropathy. Decreased levels of renal KLF4 were positively correlated with dietary‐induced renal dysfunction, including increased levels of creatinine and blood urea nitrogen. Overexpression of renal KLF4 suppressed inflammatory response in palmitic acid‐treated mouse endothelial cells. Furthermore, overexpressed KLF4 also attenuated dietary‐induced renal functional disorders, abnormal structural remodelling and inflammation. Mechanistically, KLF4 maintained renal mitochondrial biogenesis and activities to combat obesity‐induced mitochondrial dysfunction. In clinical renal biopsies and plasma, the renal Klf4 level was negatively associated with circulating levels of creatinine but positively associated with renal creatinine clearance. In conclusions, the present findings firstly supported that renal KLF4 played an important role in combating obesity‐related nephropathy, and KLF4/mitochondrial function partially determined the energy homeostasis in chronic kidney diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Overexpression Of Klf4 Improves High-fat Diet-induced Renamentioning

confidence: 99%

Section: Overexpression Of Klf4 Improves High-fat Diet-induced Renamentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Kruppel‐like factor 4 improves obesity‐related nephropathy through increasing mitochondrial biogenesis and activities

Jin

Pan

et al. 2019

J Cellular Molecular Medi

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Differential expression of Ago2‐mediated microRNA signaling in adipose tissue is associated with food‐induced obesity

et al. 2022

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Adipose tissue is a major component for the regulation of energy homeostasis by storage and release of lipids. As a core element of RNA-induced silencing complex, Ago2 plays critical role in maintenance of systemic metabolic demand. Here we show that high-fat diet feeding mice exhibited an increase in body mass alongside systematic insulin resistance and altered rate of energy expenditure. Interestingly, Ago2 expression is associated with obesity and increased in adipose tissues. Moreover, increase of Ago2 inhibited the expression of AMPKα by promoting its targeting by miR-148a, the most abundant microRNA in the adipose tissues. Those results suggested that Ago2-miR-148a-AMPKα signaling pathway play an important function in the developing obesity and adiposity and will further provide basic research data for the potential clinic treatment of obesity.

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Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives

Sun

Scherer

2023

Comprehensive Physiology

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Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

Cited by 325 publications

References 69 publications

Kruppel‐like factor 4 improves obesity‐related nephropathy through increasing mitochondrial biogenesis and activities

Kruppel‐like factor 4 improves obesity‐related nephropathy through increasing mitochondrial biogenesis and activities

Differential expression of Ago2‐mediated microRNA signaling in adipose tissue is associated with food‐induced obesity

Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives

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