2015
DOI: 10.2337/db15-0274
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Adipokines play important roles in metabolic homeostasis and disease. We have recently identified a novel adipokine Metrnl, also known as Subfatin, for its high expression in subcutaneous fat. Here, we demonstrate a prodifferentiation action of Metrnl in white adipocytes. Adipocyte-specific knockout of Metrnl exacerbates insulin resistance induced by high-fat diet (HFD), whereas adipocyte-specific transgenic overexpression of Metrnl prevents insulin resistance induced by HFD or leptin deletion. Body weight and… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

7
156
3

Year Published

2016
2016
2022
2022

Publication Types

Select...
6
1

Relationship

2
5

Authors

Journals

citations
Cited by 131 publications
(166 citation statements)
references
References 39 publications
(57 reference statements)
7
156
3
Order By: Relevance
“…9) Our previous studies showed that Metrnl is highly expressed in white adipose tissue in both rodents and humans and plays important roles in adipose biology. 3,7) Recently, in line with our animal results, Löffler et al 10) showed that Metrnl expression is higher in subcutaneous adipocytes of obese children when compared with lean children and is associated with adipocyte size.…”
supporting
confidence: 75%
See 2 more Smart Citations
“…9) Our previous studies showed that Metrnl is highly expressed in white adipose tissue in both rodents and humans and plays important roles in adipose biology. 3,7) Recently, in line with our animal results, Löffler et al 10) showed that Metrnl expression is higher in subcutaneous adipocytes of obese children when compared with lean children and is associated with adipocyte size.…”
supporting
confidence: 75%
“…Chemical and Pharmaceutical Bulletin Advance Publication the conclusion from our previous studies that adipose Metrnl is an insulin sensitizer against insulin resistance induced by a high-fat diet, 7) indicated that Metrnl might be related to the pathophysiology of insulin resistance in the patients. However, this experiment has some limitations such as the numbers of two groups are small.…”
Section: Chemical and Pharmaceutical Bulletin Advance Publicationmentioning
confidence: 99%
See 1 more Smart Citation
“…Metrnl expression is dramatically increased during adipogenesis and in white fat during obesity. Through generation of adipose-specific Metrnl transgenic overexpression and knockout mice, we demonstrate that Metrnl can upregulate PPARγ; promote white adipocyte differentiation, expandability, and lipid metabolism; inhibit adipose inflammation; and ultimately antagonize obesity-induced insulin resistance [6] . It has also been reported that Metrnl is upregulated in white adipose tissue upon acute cold exposure and in muscle after an acute bout of concurrent exercise.…”
Section: Introductionmentioning
confidence: 99%
“…Until now, there have only been a few studies exploring the function of Metrnl [1,[4][5][6] . Metrnl has a similar function to its only homologous gene, Meteorin (Metrn), which is a novel neurotrophic factor [7] .…”
Section: Introductionmentioning
confidence: 99%