Adhesion of poly(vinyl alcohol) hydrogels by the electrophoretic manipulation of phenylboronic acid copolymers

Asoh, Taka‐Aki; Takaishi, K.; Kikuchi, Akihiko

doi:10.1039/c5tb00569h

Cited by 12 publications

(7 citation statements)

References 36 publications

(70 reference statements)

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“…Using the similar method, the above research group tried to quickly bond polyvinyl alcohol (PVA) hydrogels to each other by using an electric field and a water‐soluble intermediate phenylboronic acid copolymer (Figure 9C). 111 The adhered PVA interface is stable under physiological conditions, but separation is observed in the presence of excess sugar and acid. The separated gel adhered again under the same conditions, indicating that the adhesion of the hydrogel exhibited repeatability.…”

Section: Electrostatic Attractionmentioning

confidence: 99%

“…(C) Schematic illustration of AC electrophoretic adhesion of poly(vinyl alcohol) (PVA) hydrogels by manipulation of intermediate poly(3‐methacrylamidophenylboronic acid‐co‐N,N‐dimethylacrylamide) (PBA) copolymers. Reprinted from Reference 111 with permission, copyright the Royal Society of Chemistry 2015 [Color figure can be viewed at wileyonlinelibrary.com]…”

Section: Electrostatic Attractionmentioning

confidence: 99%

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Recent progress in polymer hydrogel bioadhesives

Pei

Wang

Cong

et al. 2021

Journal of Polymer Science

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Adhesive hydrogels have broad applications in tissue adhesives, hemostatic agents, and biomedical sensors. Various bio‐inspired glues and synthetic adhesives are clinically used as conventional hemostatic agents and auxiliary tools for wound closure. Medical adhesives are needed to effectively and quickly control bleeding, thereby reducing the risk of complications caused by severe blood loss. Medical sensors need to have excellent skin compliance, mechanical properties, sensitivity, and biological safety. This review focuses on recent progress in adhesive hydrogel systems, their structures, adhesion mechanisms, construction strategies, and emerging applications in the biomedical field.

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Section: Electrostatic Attractionmentioning

confidence: 99%

Section: Electrostatic Attractionmentioning

confidence: 99%

Recent progress in polymer hydrogel bioadhesives

Pei

Wang

Cong

et al. 2021

Journal of Polymer Science

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“…PVA hydrogels are biocompatible, chemically stable and non-adhesive to proteins and cells, thus are widely used in drug delivery and tissue engineering. [32][33][34][35][36] PVA-based hydrogels have been engineered to exhibit robust mechanical properties, low coefficients of friction and structural similarity to cartilage. 37 Equally popular is PHEMA, a neutral, water-insoluble polymer synthesized via free radical polymerization of 2-hydroxyethyl methacrylate.…”

Section: Common Hydrogel Building Blocksmentioning

confidence: 99%

Chemical synthesis of biomimetic hydrogels for tissue engineering

2017

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Owing to the high water content, porous structure, biocompatibility and tissue-like viscoelasticity, hydrogels have become attractive and promising biomaterials for use in drug delivery, 3D cell culture and tissue engineering applications. Various chemical approaches have been developed for hydrogel synthesis using monomers or polymers carrying reactive functional groups. For in vivo tissue repair and in vitro cell culture purposes, it is desirable that the crosslinking reactions occur under mild conditions, do not interfere with biological processes and proceed at high yield with exceptional selectivity. Additionally, the cross-linking reaction should allow straightforward incorporation of bioactive motifs or signaling molecules, at the same time, providing tunability of the hydrogel microstructure, mechanical properties, and degradation rates. In this review, we discuss various chemical approaches applied to the synthesis of complex hydrogel networks, highlighting recent developments from our group. The discovery of new chemistries and novel materials fabrication methods will lead to the development of the next generation biomimetic hydrogels with complex structures and diverse functionalities. These materials will likely facilitate the construction of engineered tissue models that may bridge the gap between 2D experiments and animal studies, providing preliminary insight prior to in vivo assessments.

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“…A number of authors have explored LbL systems based on polyhydroxy polymers and those containing boronic acid units, forming borate/diol complexes through the LbL approach (Asoh et al., 2015 ; Nurpeissova et al., 2015 ; Aly & El-Mohdy, 2016 ). Unfortunately, those systems release a drug load over a relatively short period of time (12 h to 6 days) and also commonly exhibit an initial burst release.…”

Section: Introductionmentioning

confidence: 99%

Insulin-loaded PLGA microspheres for glucose-responsive release

Williams

et al. 2017

Drug Delivery

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Porous poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared, loaded with insulin, and then coated in poly(vinyl alcohol) (PVA) and a novel boronic acid-containing copolymer [poly(acrylamide phenyl boronic acid-co-N-vinylcaprolactam); p(AAPBA-co-NVCL)]. Multilayer microspheres were generated using a layer-by-layer approach depositing alternating coats of PVA and p(AAPBA-co-NVCL) on the PLGA surface, with the optimal system found to be that with eight alternating layers of each coating. The resultant material comprised spherical particles with a porous PLGA core and the pores covered in the coating layers. Insulin could successfully be loaded into the particles, with loading capacity and encapsulation efficiencies reaching 2.83 ± 0.15 and 82.6 ± 5.1% respectively, and was found to be present in the amorphous form. The insulin-loaded microspheres could regulate drug release in response to a changing concentration of glucose. In vitro and in vivo toxicology tests demonstrated that they are safe and have high biocompatibility. Using the multilayer microspheres to treat diabetic mice, we found they can effectively control blood sugar levels over at least 18 days, retaining their glucose-sensitive properties during this time. Therefore, the novel multilayer microspheres developed in this work have significant potential as smart drug-delivery systems for the treatment of diabetes. ARTICLE HISTORY

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Adhesion of poly(vinyl alcohol) hydrogels by the electrophoretic manipulation of phenylboronic acid copolymers

Cited by 12 publications

References 36 publications

Recent progress in polymer hydrogel bioadhesives

Recent progress in polymer hydrogel bioadhesives

Chemical synthesis of biomimetic hydrogels for tissue engineering

Insulin-loaded PLGA microspheres for glucose-responsive release

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