Adherence with topical treatment is poor compared with adherence with oral agents: Implications for effective clinical use of topical agents

Krejci‐Manwaring, Jennifer; McCarty, Martha Ann; Camacho, Fabian; Carroll, Christie L.; Johnson, Katherine; Manuel, Janeen; Balkrishnan, Rajesh; Hartle, Jennifer; Fleischer, Alan B.; Feldman, Steven R.

doi:10.1016/j.jaad.2005.10.060

Cited by 63 publications

(59 citation statements)

References 4 publications

(2 reference statements)

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“…In fact, in our study adherence was higher with oral than topical treatments. Krejci-Manwaring et al [24] had the same results, but Lee and Maibach [25] found no difference in adherence with topical or oral treatments.…”

Section: Discussionmentioning

confidence: 85%

Creation of a Tool to Assess Adherence to Treatments for Acne

et al. 2009

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Background: Acne is a disorder in which adherence has a major impact on treatment outcome. Objective: To create an easy-to-use tool to assess treatment adherence, based on a questionnaire that can be used on a daily basis by dermatologists. Methods: First, we evaluated adherence by comparing responses to a self-administered questionnaire with the dermatologist’s prescription. Second, concordance was assessed between adherence and each question of a dermatologist-directed questionnaire (DDQ) administered during the consultation. Third, DDQ questions were combined to construct a mini-questionnaire, and these combinations were tested to maximize specificity. Results: The study included 246 patients, who were prescribed topical treatment alone, combined treatment (excluding oral isotretinoin) or oral isotretinoin alone. The mini-questionnaires for oral and topical treatments had 89% specificity for detecting poor adherence. An inappropriate answer to one question classified the patient as a probable poor complier. Conclusions: Our mini-questionnaires provide dermatologists with specific tools to rapidly identify poor compliers.

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Section: Discussionmentioning

confidence: 85%

Creation of a Tool to Assess Adherence to Treatments for Acne

et al. 2009

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“…Adherence is another critical determinant of blood levels and drug effects. Furthermore, adherence to topical medication is even worse than systemic drugs, and can even vary based on the type of vehicle used (7).…”

Section: Discussionmentioning

confidence: 99%

“…Better medication adherence improves patient outcomes and has the potential to reduce healthcare costs by preventing unnecessary hospitalizations (6). Poor adherence is a particular challenge in the field of dermatology, given the preponderance of chronic diseases and messy, inconvenient topical medications that are the mainstay of therapy in dermatological diseases (7,8).…”

Section: Introductionmentioning

confidence: 99%

How often do pharmacology textbooks address medication adherence?

Farhangian¹,

Barnes²,

Huang³

et al. 2015

Journal of Dermatological Treatment

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“…Non-adherence is the main reason why treatment of chronic skin diseases is unsuccessful [30][31][32][33]. Patients more often prematurely terminate topical rather than systemic therapy [33,34]. Low adherence/compliance worsens the course of the disease and increases the cost of health care [30].…”

Section: Of Adherence To the Doctor's Recommendations (Data Not Shown)mentioning

confidence: 99%

Satisfaction with treatment of atopic dermatitis in children

Maciejewska-Franczak¹,

Majak²,

Kaczmarek³

et al. 2016

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Introduction. Atopic dermatitis is a frequent chronic skin disease in children. The major clinical manifestations include itching and dryness of the skin. The pathomechanism of skin changes results from an interaction of genetic and environmental factors as well as impairments of skin barrier function and immune response. Despite chronic treatment the disease is characterized by exacerbation and remission periods and lowers the quality of life of patients and their families. Objective. To evaluate treatment satisfaction in children with atopic dermatitis, identify components of medical care which contribute to treatment satisfaction, and evaluate the relationship between satisfaction and adherence to a doctor's recommendations. Material and methods. One hundred and nineteen children (6 months to 12 years old, mean age 4.9 years) with atopic dermatitis were enrolled in the study. The doctor performed physical examinations and history taking and filled in questionnaires evaluating the course and exacerbation of the disease, the type of administered therapy and diagnostics. The patients' parents completed two questionnaires: a questionnaire assessing satisfaction with the therapy (the type of recommended therapy, adherence to recommendations, contact with the doctor, obtained information, degree of psychological support, role of parents in taking decisions regarding the therapy) and a quality of life questionnaire. Results. The authors observed that 56% of parents were dissatisfied with the administered treatment, and 40% failed to adhere to at least one therapeutic recommendation. Parents of children with mild atopic dermatitis significantly more often stop using emollients. It was also observed that lack of treatment satisfaction in children with severe atopic dermatitis whose parents are insufficiently educated contributes to decreased adherence. The authors identified independent factors of lack of treatment satisfaction: failure to obtain enough psychological support (OR = 20.00), failure to obtain reliable information on the disease (OR = 5.91), failure to actively get engaged in the treatment procedure (OR = 5.31), dissatisfaction with the contact with the doctor (OR = 4.9), dissatisfaction with the diagnostics (OR = 4.93) and severe course of the disease (OR = 2.82). Conclusions. Elimination of risk factors of dissatisfaction with the treatment might potentially improve the adherence to chronic treatment in atopic dermatitis. atopic dermatitis, satisfaction with treatment. Wprowadzenie. Atopowe zapalenie skóry (AZS) jest częstą przewlekłą chorobą skóry u dzieci. Głównymi objawami klinicznymi są suchość skóry i świąd. Patomechanizm zmian skórnych jest wynikiem interakcji między czynnikami genetycznymi, środowiskowymi, zaburzeniami funkcjonowania bariery skórnej a odpowiedzią immunologiczną. Pomimo stosowania przewlekłego leczenia choroba przebiega z okresami zaostrzeń i remisji, obniża jakość życia pacjentów i ich rodzin. Cel pracy. Próba zdefiniowania składowych opieki medycznej, które mają wpływ n...

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Adherence with topical treatment is poor compared with adherence with oral agents: Implications for effective clinical use of topical agents

Cited by 63 publications

References 4 publications

Creation of a Tool to Assess Adherence to Treatments for Acne

Creation of a Tool to Assess Adherence to Treatments for Acne

How often do pharmacology textbooks address medication adherence?

Satisfaction with treatment of atopic dermatitis in children

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