Adherence to a combination of artemether and lumefantrine (Coartem®) in Kajo Keji, southern Sudan

Successful introduction of artesunate combination therapy is not enough to fight malaria: results from an adherence study in Sierra Leone

“…[7][8][9][10] Focusing on studies that used a related study design, our results (23% certainly non-adherent) were comparable with two studies in South Sudan (18% certainly non-adherent) 20 and Zambia (21%). 13 Both settings were similar to this study: a remote rural area; low patient educational level; treatment intake over 3 days; and this specific treatment already implemented for some time.…”

“…In this study, definitions that had already proven their reliability in two similar settings were used. 13,20 Patients were classified according to following three adherence categories: (i) certain non-adherence: patients who had any AS and/or AQ tablets remaining in the coblister package at the time of the home visit; (ii) probable non-adherence: patients with a verbal account that not all the tablets were taken but no AS+AQ co-blister package could be shown or it was empty, and/or patients with a verbal account that AS+AQ was not taken according to the prescribed time schedule or in the prescribed dosage of the treatment protocol but no AS+AQ co-blister package could be shown or it was empty; and (iii) probable adherence: patients with a verbal account of complete treatment exactly following the treatment protocol but no AS+AQ coblister package could be shown or it was empty. Table 1 shows the final classification scheme of study patients according to the treatment intake and the presence of the AS+AQ co-blister package.…”

Compliance, Safety, and Effectiveness of Fixed-Dose Artesunate-Amodiaquine for Presumptive Treatment of Non-Severe Malaria in the Context of Home Management of Malaria in Madagascar

“…Consistent with previous studies [15][16][17] based on home visits at day 3 and questionnaires addressed to the parents, compliance with treatment was classified into four categories: 1) certain compliance for patients for whom complete treatment was reported, with the treatment protocol followed exactly, supported by the evidence of an empty blister pack for the drug; 2) probable compliance for patients for whom complete treatment was reported with the treatment protocol followed exactly but without the supporting evidence of the empty blister pack; 3) probable non-compliance in cases in which all tablets were reported to have been taken, but not consistent with the prescribed time/ dosage schedule; and 4) certain non-compliance for patients for whom tablets remained in the blister pack at the time of the home visit. Compliance was assessed by the MO on day 3.…”

Patients’ adherence to antimalarial medication; self-report of patients at the Volta regional hospital of Ho, Ghana

“…In some countries where studies have been done, adherence to anti-malaria medications have been reported to be poor. [17][18][19][20] According to McDonnel et al, little attention is paid to the appropriate dosage and completion of the prescribed doses. 21 A number of studies have linked poor or nonadherence to the increased malaria related morbidity and mortality, therapeutic failure, drug resistance and missuse of the left-over drugs.…”