“…10 Initial investigations of medication synchronization programs show that patients who have signed up for the program are satisfied 11 and have improved claims-based refill rates compared to those that have not enrolled. [12][13][14] A limitation of these analyses of secondary data, however, is the potential for residual confounding, particularly due patient self-selection into the medication synchronization program through their voluntary sign-up, possibly resulting in greater tendency toward adherence than their matched counterparts who perhaps are not as committed to their regimen and therefore would not want to be locked into a rigid refill structure. 9,15 One study of medication synchronization without a clinical component found patients that voluntary signed up for synchronization already had high levels of adherence and only improved their rates slightly after participating in the program.…”