Adesão à terapêutica anti-retroviral por indivíduos com HIV/AIDS assistidos em uma instituição do interior paulista

Abstract

Inadequate adherence to highly active anti-retroviral therapy (HAART) provokes important secondary effects in people living with aids. The objective was to identify the factors that make HAART adherence easy or difficult, according to aids patients attended at a university hospital in the state of São Paulo, Brazil. We interviewed 200 diagnosed aids patients using HAART for at least 6 months. Patients were interviewed individually, using a semi-structured design. Qualitative and quantitative analysis was used. 59% of the participants were men; average age was 38.2 years; 51% did not finish basic education; 50.5% did not perform any remunerated work. Patients had been using anti-retroviral agents for an average time of 5 years. The number of anti-retroviral pills ranged from 3 to 24. The main difficulties mentioned for adherence were: taste, size, number, smell of pills (40.0%); intense collateral effects (14.4%); psychological factors (13.7%); different times to take the pills (10.8%). Patients mentioned the following facilitators: coincidence of times to take the drugs (26.2%), no facility (16.4%), and administration associated to some habit (16.0%). The nursing group needs to reinforce supervised surveillance, educational and intervention actions.

Associação entre uso de álcool em indivíduos com AIDS e adesão ao tratamento antirretroviral: uma revisão da literatura

“…Desde que a doença foi descoberta, no início da década de 1980, muitos avanços foram dados em relação à maior compreensão da doença e desenvolvimento terapêutico. Atualmente, uma combinação de medicamentos conhecida como HAART (highly active antiretroviral therapy) é indiscutivelmente reconhecida por tornar mais lento o curso da doença e prolongar a vida 1,2 . Entretanto, um novo problema emergiu com o desenvolvimento e o uso dos antirretrovirais: a adesão aos esquemas terapêuticos.…”

Evaluation of inadequate anti-retroviral treatment in patients with HIV/AIDS

“…Most therapies were triple (n = 18); 7 consisted of 4 drugs and 2 with 5 combinations. Gir Vaichulonis and Oliveira 19 found similar data, since 84.5% of their patients were using a regimen of up to 3 medications. Therapies involving a combination of more than 4 drugs are used in order to achieve immune rescue or as a resource for those patients whose treatment has already encountered some kind of resistance.…”

Evaluation of laboratory markers of progression of HIV disease to death

“…Gir et al 10 determined a median age of 38.2 years old, while it was 36 years old in the study of Lewden 18 . All these findings are in agreement with the prevalence determined in this work.…”

“…In a study involving 200 patients in a hospital in Ribeirão Preto, in the State of São Paulo, Brazil, a rate of 59% male patients was determined 10 , while Cavassani et al 11 found 69.1%; however, in the current phase of the disease, an increased incidence of infection among women is occurring 12 .…”