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Cited by 5 publications
(2 citation statements)
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“…This helps alleviate the daunting task of transduction of each tumor cell (17). In contrast, genetic immunopotentiation efforts involve the modification of either immune or tumor cells to augment immunological recognition of neoplastic cells (18). In addition, investigators have utilized a variety of strategies to modify resistance or sensitivity of cells for chemotherapy or radiation in order to enhance the therapeutic index (19,20).…”
Section: Cancer Gene Therapy Approachesmentioning
confidence: 99%
“…This helps alleviate the daunting task of transduction of each tumor cell (17). In contrast, genetic immunopotentiation efforts involve the modification of either immune or tumor cells to augment immunological recognition of neoplastic cells (18). In addition, investigators have utilized a variety of strategies to modify resistance or sensitivity of cells for chemotherapy or radiation in order to enhance the therapeutic index (19,20).…”
Section: Cancer Gene Therapy Approachesmentioning
confidence: 99%
“…Double mutant AdV additionally lacking the integrin-binding penton base RGD motif were shown to efficiently target epidermal growth factor receptor or epithelial cell adhesion molecules, depending on the choice of the bispecific linker, resulting in a relative glioma/normal brain transduction ratio of 60 times that achieved with native AdV. Adenovirus-mediated IFN-γR gene transfer was shown to be effective in augmenting the biological activity of IFN-γ, a strategy which should be useful in studying other applications of cytokine receptor-based gene therapy for cancer [28]. Regarding the transfer of p53, Ad5CMV-p53-infected cells underwent apoptosis, and cell growth was greatly suppressed.…”
Section: Vectors (Table 1)mentioning
confidence: 99%