Adenovirus-mediated expression of BmK CT suppresses growth and invasion of rat C6 glioma cells

Du, Jun; Fu, Yuejun; Wang, Jia‐Ning; Liang, Aihua

doi:10.1007/s10529-013-1167-9

Cited by 9 publications

(2 citation statements)

References 19 publications

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“…BmKCT interacts specifically with human glioma (SHG-44) cells, but not with normal astrocytes, as a Cl‒ channel blocker [54] and inhibits the invasion and migration of rat glioma (C6) cells by antagonizing MMP-2 [55]. Similarly, the recombinant adenovirus-produced BmKCT, Ad-BmKCT, reduced rat glioma (C6) cell viability in vitro and the growth and metastasis of xenografted rat glioma (C6) tumors in female athymic nude mice following intratumoral injection of Ad- BmKCT (100 µL, 1010 viral particles, every five days) [56].…”

Section: Effect Of Scorpion and Spider Venoms On Cancer Cellsmentioning

confidence: 99%

Scorpion and spider venoms in cancer treatment: state of the art, challenges, and perspectives

Rapôso

2017

J Clin Transl Res

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Background and Aim: Animal venoms comprise a mix of bioactive molecules with high affinity for multiple targets in cells and tissues. Scorpion and spider venoms and purified peptides exhibit significant effects on cancer cells, encompassing four potential mechanisms: 1) induction of cell cycle arrest, growth inhibition, and apoptosis; 2) inhibition of angiogenesis; 3) inhibition of invasion and metastasis; and 4) blocking of specific transmembrane channels. Tumor biology is complex and entails many intertwined processes, as reflected in the putative hallmarks of cancer. This complexity, however, gives rise to numerous (potential) pharmacological intervention sites. Molecules that target multiple proteins or pathways, such as components of animal venoms, may therefore be effective anti-cancer agents. The objective of this review was to address the anti-cancer properties and in vitro mechanisms of scorpion and spider venoms and toxins, and highlight current obstacles in translating the preclinical research to a clinical setting.Relevance for patients: Cancer is a considerable global contributor to disease-related death. Despite some advances being made, therapy remains palliative rather than curative for the majority of cancer indications. Consequently, more effective therapies need to be devised for poorly responding cancer types to optimize clinical cancer management. Scorpion and spider venoms may occupy a role in the development of improved anti-cancer modalities.

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Section: Effect Of Scorpion and Spider Venoms On Cancer Cellsmentioning

confidence: 99%

Scorpion and spider venoms in cancer treatment: state of the art, challenges, and perspectives

Rapôso

2017

J Clin Transl Res

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“…Targeting BmK CT to C6 glioma cells specifically through this delivery system had been developed by them. Thus, the replication-defective recombinant adenovirus Ad-BmK CT could provide a powerful delivery system to treat glioblastoma 52 Moreover, improved antitumor effects on the subcutaneous U251 or SHG-44 tumors of the nude mouse models had been achieved by the CTX-Onc conjugate compared to the CTX+Onc control. These results were indicative of the promotion of the tumor targeting of Onc through the chemically reversible conjugated CTX.…”

Section: Data Extractionmentioning

confidence: 99%

Untitled

2018

IJPSR

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The use of scorpion venom has a very old history in traditional medicine for thousands years ago in China, India and Africa worldwide. The inhibition of cancer progression and induce apoptosis have shown in an increasing number in-vitro and in-vivo studies. We accomplished this systematic review to evaluate the performance of scorpion venom and its components in the growth inhibition of cancer cell lines. To provide a full data for future researches, the in-vitro and in-vivo studies were adopted in this research. The literature search for the published articles from January 1 st , 1968 to January 1 th , 2018 was done in PubMed, ISI Web of Science, Scopus, and Science Direct. All the articles were independently screened by applying some predefined criteria by two reviewers in three consecutive steps. We identified 53 eligible studies from among 1,209 studies. So far, scorpion venom and its components have been discovered to inhibit the growth of 38 various types of cancer cell lines. This was the first systematic review includes some tables that provided some valuable information to the reader on the therapeutic properties of scorpion venom and its components in the sphere of cancer treatment. We found some studies showing that these agents have been able to inhibit the growth of cancer cell lines, while having no effects on the normal cells using the same doses. The findings of this research strongly reinforced the hypothesis that these agents provide a new efficient approach to cancer treatment.

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Biological evaluation of [99mTc]Tc-labeled Buthus martensii Karsch Chlorotoxin peptide for glioma imaging

Liu

Wang

Zhao

et al. 2020

J Radioanal Nucl Chem

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Adenovirus-mediated expression of BmK CT suppresses growth and invasion of rat C6 glioma cells

Cited by 9 publications

References 19 publications

Scorpion and spider venoms in cancer treatment: state of the art, challenges, and perspectives

Scorpion and spider venoms in cancer treatment: state of the art, challenges, and perspectives

Untitled

Biological evaluation of [99mTc]Tc-labeled Buthus martensii Karsch Chlorotoxin peptide for glioma imaging

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