2008
DOI: 10.3748/wjg.14.180
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Abstract: Gastric cancer is one of the most common malignancies worldwide. With current therapeutic approaches the prognosis of gastric cancer is very poor, as gastric cancer accounts for the second most common cause of death in cancer related deaths. Gastric cancer like almost all other cancers has a molecular genetic basis which relies on disruption in normal cellular regulatory mechanisms regarding cell growth, apoptosis and cell division. Thus novel therapeutic approaches such as gene therapy promise to become the a… Show more

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Cited by 28 publications
(19 citation statements)
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References 52 publications
(45 reference statements)
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“…gastric cancer is a genetic disease that develops from a multi-step process (3). Single or multiple mutations in genes related to growth control, apoptosis, invasion and metastasis form the molecular genetic basis of malignant transformation and tumor progression (4).…”
Section: Introductionmentioning
confidence: 99%
“…gastric cancer is a genetic disease that develops from a multi-step process (3). Single or multiple mutations in genes related to growth control, apoptosis, invasion and metastasis form the molecular genetic basis of malignant transformation and tumor progression (4).…”
Section: Introductionmentioning
confidence: 99%
“…Current therapeutic modalities include surgical resection, radiosurgical/external irradiation, chemotherapy and biological therapy, however, the overall prognosis is poor (1,2). Single or multiple mutations in genes related to growth control, apoptosis, invasion and metastasis form the molecular genetic basis of malignant transformation and tumor progression (3).…”
Section: Introductionmentioning
confidence: 99%
“…Gastric cancer is the second most common cause of cancer death worldwide [1] . Within the Asian region, high incidence areas include Japan, China and Korea.…”
Section: Introductionmentioning
confidence: 99%