Adenosquamous Carcinoma of the Duodenum

Cruz, Alberto De La; Cruz, ErnestoP.; Sánchez, María José; Ortiz, Santiago; Lobato, Alejandro; Ovejero-Merino, Enrique

doi:10.1016/s0344-0338(11)80345-6

Cited by 8 publications

(3 citation statements)

References 11 publications

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“…Although mucinous carcinoma occurs frequently in the gastrointestinal tract, it is scarcely found in the duodenum. Signet‐ring cell carcinoma, adenosquamous cell carcinoma and small cell carcinoma have also been reported 16 –18…”

Section: Discussionmentioning

confidence: 99%

“…Signet-ring cell carcinoma, adenosquamous cell carcinoma and small cell carcinoma have also been reported. [16][17][18] Assessment of cell proliferation has been a valuable method for estimating tumor growth, potential for metastasis and prognosis in a variety of human cancers. Although several studies have evaluated cell proliferation fractions in sporadic or FAP-associated duodenal adenomas and carcinomas, little is known regarding the proliferative characteristics of primary duodenal carcinomas.…”

Section: Discussionmentioning

confidence: 99%

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Primary adenocarcinoma of the duodenum in the elderly: Clinicopathological and immunohistochemical study of 17 cases

Arai

Murata

Sawabe

et al. 1999

Pathology International

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Seventeen cases of primary duodenal adenocarcinoma occurring in the elderly (older than 65 years) were examined to clarify their clinicopathological features and biological behavior. The mean age was 77.4 years (range, 66-104), and there was no appreciable difference in the incidence between the sexes (female: male ratio, 8: 9). Thirteen patients had tumors located in the first portion of the duodenum, three in the second portion and one in the third portion. Grossly, there were three varieties of lesions: six polypoid, four flat-elevated and seven ulcerative-invasive. Sixteen cases showed well-differentiated adenocarcinoma, three of which were difficult to distinguish from adenoma, and one was poorly differentiated adenocarcinoma. Three of 16 tumors had poor differentiation in the invasive area, whereas mucosal lesions were well differentiated. Eight tumors had invaded the duodenal wall with occasional involvement of the pancreas. Immunohistochemistry demonstrated p53 protein overexpression in two intramucosal (22.2%) and five invasive (62.5%) cancers. In the intramucosal area the mean Ki-67-positive rate (PR) of the tumors with distant metastasis was significantly higher than that of the tumors without metastasis (46.0 vs 31.6%; P < 0.05), while there was no significant difference in the association between PR and gross feature or depth of the tumors. Clinical follow-up showed three of the five patients with invasive cancer died of carcinoma within 28 months. Compared with published data from other investigators, the results of the present study indicate a proximal shift of duodenal carcinoma in the elderly. Furthermore, it is concluded that invasive duodenal adenocarcinomas with high PR should be considered as potentially aggressive tumors, although their histology may indicate a high degree of differentiation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary adenocarcinoma of the duodenum in the elderly: Clinicopathological and immunohistochemical study of 17 cases

Arai

Murata

Sawabe

et al. 1999

Pathology International

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“…A review of the literature revealed only two cases of squamous cell carcinoma of the duodenum [2, 3]. Adenosquamous carcinoma was also reported [4]. The author encountered a case of primary pure squamous cell carcinoma of the duodenum and reported herein.…”

Section: Introductionmentioning

confidence: 99%

Primary Pure Squamous Cell Carcinoma of the Duodenum: A Case Report

Terada

2010

Gastroenterol Res

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Only two cases of squamous cell carcinoma of the duodenum have been reported in the literature. The author herein reports a case of squamous cell carcinoma of the duodenum. A 75-year-old man was admitted to our hospital because of nausea, vomiting, and weakness. An endoscopic examination revealed a duodenal tumor. The tumor was circumferential elevated one with duodenal obstruction, and located in the descending part near and distal to the ampulla of Vater. Imaging modalities also detected the duodenal tumor, but did not show tumors of other locations including the pancreas. The duodenal tumor was different from ampullary tumor and pancreatic tumor. Six biopsies were obtained from the duodenal tumor. All the six biopsies showed malignant cells arranged in a medullary pattern. The malignant cells showed hyperchromatic nuclei, and mitotic figures were scattered. Keratinization and intercellular bridges were recognized. The pathologic features were interpreted as a squamous cell carcinoma of the duodenum. The carcinoma was pure squamous cell carcinoma without differentiation into adenocarcinoma or endocrine carcinoma. Operation was not possible because of the patient’s age and weakness. The patient was treated by chemotherapy and radiation, but he showed a downhill course. Metastases emerged, and he died of systemic metastasis 17 months after the first presentation. Autopsy was not performed.

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