Adenosine mechanisms in the regulation of breathing in the rat

Wessberg, Per; Hedner, Jan; Hedner, Thomas; Persson, Bengt; Jonason, Jan

doi:10.1016/0014-2999(84)90678-2

Cited by 63 publications

(34 citation statements)

References 16 publications

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“…The effects which we describe are also unlikely to be mediated by effects on the central nervous system. Adenosine (Kattwinkel & Darnall, 1982), and its synthetic analogues (Lagercrantz et al, 1984;Wessberg et al, 1984;Hedner et al, 1982;Mueller et al, 1982) inhibit respiration when applied directly to the brain, and adenosine administered intravascularly appears to cross the blood-brain barrier slowly, if at all (Berne et al, 1974). The aortic chemoreceptors appear to play a significant role in the control of respiration in some species but in man they appear to be relatively unimportant (Whipp & Wassermann, 1980).…”

Section: Discussionmentioning

confidence: 99%

Adenosine stimulates respiration in man.

Watt¹,

Routledge²

1985

Brit J Clinical Pharma

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Section: Discussionmentioning

confidence: 99%

Adenosine stimulates respiration in man.

Watt¹,

Routledge²

1985

Brit J Clinical Pharma

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“…Adenosine mechanisms were originally implicated in the central nervous regulation of breathing in several species (Hedner et al, 1982;Mueller et al, 1984;Wessberg et al, 1984;Eldridge and Millhorn, 1987;Norsted et al, 1987;Bissonette et al, 1991;Barros and Branco, 2000). Adenosine injected into the caudal nucleus of the NTS decreased respiratory frequency by an action on A 2A receptors expressed on glutamatergic nerve terminals (Phillis et al, 1997).…”

Section: Central Control Of Respirationmentioning

confidence: 99%

Purinergic Signaling in the Airways

Burnstock

Brouns²,

Adriaensen³

et al. 2012

Pharmacol Rev

173

158

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“…The carotid bodies in animals [12,13], and also probably in humans [4,5], are stimulated directly by adenosine. Centrally-mediated respiratory depression by adenosine has also been observed in animals [14]. We argued that, if peripheral adenosine-related mechanisms could be silenced, central mechanisms might be elucidated.…”

Section: Discussionmentioning

confidence: 88%

The effect of dipyridamole and theophylline on hypercapnic ventilatory responses: the role of adenosine

Griffiths

Christie²,

Parsons³

et al. 1997

Eur Respir J

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The purine nucleoside, adenosine, has been implicated as a neuromodulator in central respiratory depression during prolonged exposure to hypoxia. It may also be a mediator of hypoxic hyperpnoea, acting on the carotid bodies. As there may be adenosine-sensitive mechanisms of hypoxic respiratory control, we sought to determine whether adenosine might be involved as a respiratory modulator in another central but non-oxygen-related control mechanism, the ventilatory response to hyperoxic hypercapnia.Twelve normal subjects were studied following 3 days of oral treatment with placebo, dipyridamole (which potentiates adenosine effects by inhibiting cellular uptake), and theophylline (a specific adenosine antagonist of cell surface receptors). The drugs were given in a random order, double-blind fashion. Resting endtidal carbon dioxide tension (PET,CO 2 ) and the maximum rate of isometric inspiratory pressure change at the mouth ((dP/dt )max), an index of respiratory drive, were determined in all subjects on each treatment. Hyperoxic, hypercapnic ventilatory responses were determined in seven of these subjects using a rebreathing technique. For each hypercapnic response, minute ventilation (V 'E) and (dP/dt )max were plotted against PET,CO 2 breath-by-breath.Resting PET,CO 2 breathing room air was lower with theophylline (5.47 (SD 0.21) kPa) than with placebo (5.74 (0.26) kPa) or dipyridamole (5.86 (0.34) kPa), with no significant drug differences in resting (dP/dt )max. However, neither the slope nor the PET,CO 2 intercept of the relationship between ventilation or respiratory drive and PET,CO 2 were altered by the study drugs under hyperoxic conditions. We conclude that endogenous adenosine-related mechanisms are unlikely to be involved in determining either the sensitivity or the threshold of the ventilatory response to carbon dioxide under hyperoxic conditions. However, in normoxia, a centrally-acting, tonic, adenosine-mediated, respiratory modulation is not ruled out.

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Adenosine mechanisms in the regulation of breathing in the rat

Cited by 63 publications

References 16 publications

Adenosine stimulates respiration in man.

Adenosine stimulates respiration in man.

Purinergic Signaling in the Airways

The effect of dipyridamole and theophylline on hypercapnic ventilatory responses: the role of adenosine

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