2002
DOI: 10.1590/s0001-37652002000300007
View full text | Cite
|
Sign up to set email alerts
|

Abstract: The nucleoside adenosine plays an important role as a neurotransmitter or neuromodulator in the central nervous system, including the retina. In the present paper we review compelling evidence showing that adenosine is a signaling molecule in the developing retina. In the chick retina, adenosine transporters are present since early stages of development before the appearance of adenosine A1 receptors modulating dopamine-dependent adenylate cyclase activity orA2 receptors that directly activate the enzyme. Expe… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
26
1
1

Year Published

2005
2005
2016
2016

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 43 publications
(29 citation statements)
references
References 91 publications
(53 reference statements)
1
26
1
1
Order By: Relevance
“…Although it was not possible under our experimental conditions (retina isolated from the epithelium) to observe full recovery of the extracellular adenosine level in the dark after a period of intense light illumination, our observations nonetheless indicate that during bright light illumination, the extracellular level of adenosine is likely the lowest. Overall, our results are in complete agreement with the darkness-and nighttimemimicking effects of exogenous adenosine in the vertebrate retina that have been reported previously (Blazynski and Perez, 1991;Rey and Burnside, 1999;Paes-De-Carvalho, 2002;Sun et al, 2002;Stella et al, 2003).…”
Section: Environmental Lighting Conditions Modulate the Extracellularsupporting
confidence: 93%
“…In fact, dark adaptation during the day has been reported to decrease the oxygen tension of the mammalian retina and especially in the synaptic layers and outer nuclear layer, where it reaches 0 mmHg (Linsenmeier, 1986;Ahmed et al, 1993). If the clock produces a slight hypoxic-like state at night, then the resultant increase in adenosine may have a neuroprotective effect (Dunwiddie and Masino, 2001;Latini and Pedata, 2001;Paes-De-Carvalho, 2002) in addition to its neuromodulatory role.…”
Section: Circadian Control Of Extracellular Adenosinementioning
confidence: 99%
See 1 more Smart Citation
“…Adenosine is a signaling molecule in the retina. 35 Adenosine, along with the excitatory amino acids glutamate and aspartate, is known to be released from ischemic and hypoxic neural tissue. 36,37 We have demonstrated an asymmetrical response to exogenous adenosine in retinal arteries in that extraluminal administration of adenosine produces a dosedependent dilation, whereas intraluminal adenosine fails to produce a significant dilation response.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, beyond the well-described role of A 2A R during CNS development, the genetic deletion of A 2A R promotes the development of relative myopia [90], demonstrating the importance of A 2A R for normal eye function. The adenosinergic system is present in the retina from early embryogenesis, and it also plays an important role for normal retinal development [91,92]. …”
Section: A2ar Blockade: Potential Therapeutic Strategy For Neuroprotementioning
confidence: 99%