Biochemical Pharmacology volume 79, issue 2, P180-187 2010 DOI: 10.1016/j.bcp.2009.08.010 View full text
Avishag K. Emanuelov, Asher Shainberg, Yelena Chepurko, Doron Kaplan, Alex Sagie, Eyal Porat, Michael Arad, Edith Hochhauser

Abstract: Cardiotoxicity associated with doxorubicin (DOX) treatment limits the therapeutic efficiency of this drug against cancer. 2-Chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (Cl-IB-MECA), a selective agonist of A(3) adenosine receptor (A(3)R), reduces DOX toxicity in newborn rat cultured cardiomyocytes. The study's aim was to determine whether the protection demonstrated by Cl-IB-MECA attenuates cardiac depression in vivo. In addition, we wished to examine whether this protective pathway affects the sar…

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