Adenomatoid tumours of the gastrointestinal tract – a case‐series and review of the literature

Abstract

Adenomatoid tumours of the gastrointestinal tracta case-series and review of the literature Aims: Adenomatoid tumours are mesothelial-derived benign neoplasms with a predilection for the genital tract. Extragenital sites are rare and can cause significant diagnostic challenges. Herein, we describe the clinicopathological features of a cohort of adenomatoid tumours involving the gastrointestinal tract and liver in order to more clearly characterise their histological findings and aid in diagnosis. Methods and results:The pathology databases at four institutions were searched for adenomatoid tumours involving the gastrointestinal tract or liver, yielding eight cases. Available clinicoradiological and followup data were collected from the medical records. Six tumours were incidentally discovered during imaging studies or at the time of surgical exploration for unrelated conditions; presenting symptoms were unknown in two patients. Histologically, the tumours were well-circumscribed, although focal illdefined borders were present in four cases. No infiltration of adjacent structures was identified.Architectural heterogeneity was noted in five (63%) tumours; an adenoid pattern often predominated. The neoplastic cells were flattened to cuboidal with eosinophilic cytoplasm. Cytoplasmic vacuoles mimicking signet ring-like cells were present in five (63%) cases. Three (38%) cases showed involvement of the mesothelium with reactive mesothelial hyperplasia. Cytological atypia or increased mitotic activity was not identified. The surrounding stroma ranged from oedematous/myxoid to densely hyalinised. Immunohistochemistry confirmed mesothelial origin in all cases evaluated. No patients developed recurrence of disease. Conclusions: The current study evaluates the clinicopathological findings in a collective series of gastrointestinal and hepatic adenomatoid tumours, correlating with those described in individually reported cases. We highlight common histological features and emphasise variable findings that could mimic a malignant neoplasm.

A Rare Pancreatic Tumor with Adenomatoid Tumor-like Findings

“…The pathogenesis of adenomatoid tumor in the pancreas is considered to include residual mesothelial cells in the developmental stage, although the exact mechanism is unknown. Importantly, to our knowledge, there have been no cases of recurrence, and adenomatoid tumors are considered to have a good prognosis (10).…”

Epididymal adenomatoid tumor: a case report and literature review

“…Adenomatoid tumor is a very rare benign neoplasm affecting mainly female and male genital tracts [1][2][3]. However, other extra-genital organs can be involved by adenomatoid tumors, such as adrenal gland, pleura, mediastinum, mesentery, omentum, liver and gastrointestinal tract [4][5][6][7][8]. The name "adenomatoid tumor" was first introduced by Golden and Ash as the origin of these tumors was controversial in 1945 when they reported their study [9].…”