Adenoid cystic carcinoma of the Bartholin's gland: Report of two cases and review of the literature

Yang, Sook-Young Vivian; Lee, Jeong‐Won; Kim, Woo-Sun; Jung, Kyoung-Lan; Lee, Sun-Joo; Lee, Je‐Ho; Bae, Duk-Soo; Kim, Byoung-Gie

doi:10.1016/j.ygyno.2005.08.030

Cited by 51 publications

(67 citation statements)

References 18 publications

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“…The major histological types of BGC include squamous cell and adenocarcinoma, and the other types include adenoid-cystic, transitional or undifferentiated carcinomas; ACC accounts for ~25% of all BGCs (6). An extensive search of the currently available cases revealed that only 62 were ACC of Bartholin’s gland (7). BGCs are slow-growing tumors associated with frequent recurrences that exhibit local invasion, and metastasis to tissues and/or organs.…”

Section: Discussionmentioning

confidence: 99%

Bartholin gland carcinoma: A case report

Zhan

Liu

et al. 2014

Oncology Letters

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Bartholin gland carcinomas (BGCs) are extremely rare tumors accounting for <1% of all female genital malignancies. The current study presents a 49-year-old female with an eight-year history of BGC. A mass was identified in the vulva and the patient underwent an excisional biopsy, which revealed a left Bartholin adenoid cystic carcinoma. The patient subsequently received surgery, chemotherapy and biological therapy, and has survived. Therefore, the present case indicates that surgery is important for the treatment of BGC, however; multimodal therapy may be a more effective treatment strategy.

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Section: Discussionmentioning

confidence: 99%

Bartholin gland carcinoma: A case report

Zhan

Liu

et al. 2014

Oncology Letters

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“…These symptoms can even be experienced before the physical appearance of any vulval mass. Among other nonspecific signs like bleeding, dyspareunia, and/or discharge from an abscess [4], the presence of an inguinal lymph node should be considered as being highly suspicious of malignancy. However, in most cases of symptomatic Bartholin’s cysts, patients will be treated with only drainage and marsupialization as the diagnosis of a benign condition is expected.…”

Section: Discussionmentioning

confidence: 99%

Brain and lung metastasis of Bartholin’s gland adenoid cystic carcinoma: a case report

et al. 2013

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IntroductionAdenoid cystic carcinoma of Bartholin’s gland is a very rare disease.Case presentationA 48-year-old premenopausal woman of Caucasian origin was delivered adjuvant pelvic and inguinal radiotherapy after prior complete left Bartholin’s gland tumor excision and inguinal lymph node dissection for adenoid cystic carcinoma of Bartholin’s gland with one metastatic inguinal lymph node.Two years after primary treatment, she presented to the Emergency Room with acute headache, hypoacousia, decrease in visual acuity, and a decrease in right leg muscle strength. A cranial magnetic resonance imaging scan demonstrated three cystic brain lesions with associated perifocal edema. Chest and abdomen computed tomography scans and a magnetic resonance imaging scan of the pelvis did not find any metastatic or residual disease elsewhere. A physical examination found no local recurrence.Stereotactic brain biopsies with pathology examination revealed the presence of adenoid cystic carcinoma metastasis. She thus received 30Gy of brain radiotherapy but, three months later, the brain lesions did not decrease in size and left mid lobular lung lesions appeared on her chest computed tomography scan. A mid left lobe lung excision was undertaken followed by chemotherapy consisting of six cycles of cyclophosphamide, adriamycin and cisplatin. Five months after beginning chemotherapy, the brain disease progressed and our patient died.ConclusionOur case report shows the difficulty in managing brain and lung metastasis of Bartholin’s gland adenoid cystic carcinoma as no consensus on the optimal treatment exists.

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“…Es necesario un margen de resección adecuado, ya que este tumor puede infiltrar la pared lateral de la vagina y la fosa isquiorectal. No se recomienda la vulvectomía total como primera alternativa debido a que no ha demostrado mejoría en la sobrevida, lo que se explica por la radioterapia adyuvante que reciben los pacientes con márgenes positivos 1 .…”

Section: Presentación Del Casounclassified

“…En la intervención con intención curativa realizar lifadenectomía regional y radioterapia posterior en caso de encontrar criterios oncológicos de agresividad 1,[3][4][5][6][7][8][9][10][11][12] .…”

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Metastasis pulmonares tardías de carcinoma adenoideo quístico de la glandula de bartolino.

Quiroz

Moya

Rojas

et al. 2017

Rev. chil. obstet. ginecol.

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RESUMENEl carcinoma adenoideo quístico de la glándula de Bartolino (GB) es una entidad infrecuente, de crecimiento lento y comportamiento agresivo con alta recurrencia local y metástasis.Presentamos el caso de una paciente de 48 años, con antecedente de tratamiento quirúrgico de un absceso Bartolino derecho. La biopsia demostró un carcinoma adenoideo quístico (CAQ) de la GB, por lo que se realizó hemivulvectomía radical derecha y linfadenectomía inguinofemoral. El resultado de la biopsia mostró 4 ganglios positivos de 12 y margen lateral positivo a menos de 2 mm. Por lo que se realizó adyuvancia con radioterapia.La paciente no se presenta a su control y acude luego de tres años por dolor urente desde cadera izquierda hacia rodilla y cara lateral de la pierna y pie. Se realiza cintigrama óseo que muestra lesión osteoblástica sacroilíaca izquierda de 2 cm, por lo que se completó estudio de diseminación con tomografía computada de tórax, abdomen y pelvis con contraste que evidenció múltiples lesiones nodulares pulmonares bilaterales de distribución generalizada en parénquima central, periférico y subpleurales.Se deriva al Instituto Nacional del Tórax, completando estudio preoperatorio y se realizó una biopsia quirúrgica por video toracoscopía resecando un nódulo subpleural, el informe histológico señaló una metástasis de CAQ concordante con primario en GB.La paciente fue presentada en el comité oncológico y se indicó radioterapia paliativa a lesión sacroilíaca y control clínico ambulatorio. Ha evolucionado estable desde el punto de vista funcional pulmonar. PALABRAS CLAVE: Glándulas de Bartolino; carcinoma adenoideo quístico; metástasis neoplásicas ABSTRACTAdenoid cystic carcinoma of Bartholin glands (BG) is a rare, slow-growing but a highly aggressive tumor with remarkable capacity for local recurrence and distant metastasis. We present the case of a 48 year-old female patient with a history of surgical treatment for right Bartholin abscess. The biopsy showed a cystic adenoid carcinoma of the BG, which led to radical hemivulvectomy and inguinofemoral lymphadenectomy. The biopsy show inguinal lymph node metastasis on 4 of 12 lymph nodes and positive surgical resection margin. Adjuvant radiotherapy was applied.

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Adenoid cystic carcinoma of the Bartholin's gland: Report of two cases and review of the literature

Cited by 51 publications

References 18 publications

Bartholin gland carcinoma: A case report

Bartholin gland carcinoma: A case report

Brain and lung metastasis of Bartholin’s gland adenoid cystic carcinoma: a case report

Metastasis pulmonares tardías de carcinoma adenoideo quístico de la glandula de bartolino.

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