Adenoid cystic breast carcinoma: a salivary gland-type tumour with excellent prognosis and implications for management

Soon, Sue Rene; Yong, Wei Sean; Wong, Chow Yin; Ho, Bernard; Tan, Puay Hoon

doi:10.1080/00313020802036830

Cited by 11 publications

(5 citation statements)

References 9 publications

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“…Supporting findings in previous reports [15,17-21,27,29,31,35-38,48,50,52,54-57], the majority of breast-ACC in the SEER Program was ER-negative/PR-negative; however, hormone receptor-positive tumors have also been described in a minority of cases [22,23,25,32,34,42,58]. Although information on HER-2-neu is not available in the SEER Program, other series have uniformly reported HER-2-neu-negative status in breast-ACC [18,20,21,23,31,34,37,38,42,50,52,55,56].…”

Section: Discussionsupporting

confidence: 91%

“…In contrast to what might be expected with ER-negative, PR-negative, HER-2-neu-negative (triple-negative) breast cancers, the majority of cases of breast-ACC in the SEER Program rarely involved regional LN and most were associated with excellent survival. These findings support clinical reports that largely [12,20-25,29,31,32,34-38,41,42,48,50-52,55,56], but not exclusively [21-24,34,42,49], describe absence of LN involvement and excellent survival [22,24,25]. Metastatic breast-ACC has been rarely reported at initial diagnosis [22], and only one case was observed in the SEER Program over a 30-year period.…”

Section: Discussionsupporting

confidence: 90%

“…Although information on HER-2-neu is not available in the SEER Program, other series have uniformly reported HER-2-neu-negative status in breast-ACC [18,20,21,23,31,34,37,38,42,50,52,55,56]. Like HER-2-neu negativity, c-kit expression is typically a poor prognostic feature that also characterizes breast-ACC [18,21,29,31,34] as well as medullary breast cancer, another basal-like breast cancer [59,60].…”

Section: Discussionmentioning

confidence: 99%

“…The mainstay of therapy for breast-ACC has been surgical excision with or without local radiotherapy, with infrequent use of chemotherapy and hormonal therapy [21-24,38,41,42,52,55]. Single or multiple recurrences may occur years after initial diagnosis [8,11,13,20,21,23,27,32,33,39,40,49], and a similar pattern of recurrence has been observed for other triple-negative breast cancers [61].…”

Section: Discussionmentioning

confidence: 99%

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Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study

et al. 2010

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IntroductionAdenoid cystic carcinoma of the breast (breast-ACC) is a rare and special type of basal-like tumor for which scant population-based descriptive data exist. We sought to provide new population-based information on breast-ACC incidence, relative survival, and associated cancer risk in the United States.MethodsUsing data from the Surveillance, Epidemiology and End Results Program, we calculated age-adjusted incidence rates (IRs), IR ratios (IRRs), and relative survival for breast-ACC, and standardized incidence ratios (SIRs) for other cancers.ResultsOverall 338 women (IR = 0.92/1 million person-years) were diagnosed with breast-ACC during 1977 to 2006. Blacks had 39% lower IRs than Whites (IRR = 0.61, 95% confidence interval = 0.37 to 0.96), and IRs remained constant over the 30-year period. Ninety-five percent of cases presented with localized stage (n = 320; IR = 0.87), and the highest IRs were observed for estrogen receptor (ER)-negative/progesterone receptor (PR)-negative tumors (IR = 0.56). Like other typically ER-negative tumors, age-specific IRs increased until midlife and then plateaued. Five-year, 10-year, and 15-year relative survival was 98.1%, 94.9%, and 91.4%, respectively. The risk of female breast cancer was not increased following (SIR = 0.89, 95% confidence interval = 0.43 to 1.64) or preceding (SIR = 0.71, 95% confidence interval = 0.28 to 1.46) breast-ACC. Similarly, no association was observed for breast-ACC and risk of all other cancers combined, solid tumors, or lymphohematopoietic malignancies.ConclusionsBreast-ACC among women is characterized by ER-negative/PR-negative expression, rare regional lymph node involvement, a favorable prognosis with excellent survival, and absence of associated cancers. These findings reinforce the importance of tailored treatments for breast-ACC and lend credence to the apparent heterogeneity of basal-like breast cancers.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study

et al. 2010

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“…In general, basal-like carcinoma breast carcinomas are characterized by a poor prognosis, yet ACC had been previously associated with an excellent prognosis [21][22][23][24][25][26][27], so although ACCs share some features of basallike carcinomas, there are important biological differences.…”

Section: Discussionmentioning

confidence: 99%