Adenocarcinoma of the Uterine Cervix with Predominantly Villogladular Papillary Growth Pattern

Kaku, Tsunehisa; Kamura, Toshiharu; Shigematsu, Toshiyuki; Sakai, Kunihiro; Nakanami, Naoyuki; Uehira, Kenji; Amada, Satoshi; Kobayashi, Hiroaki; Saito, Toshiaki; Nakano, Hitoo

doi:10.1006/gyno.1996.4539

Cited by 59 publications

(62 citation statements)

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“…Heatley (10) retrospectively collected 140 cases of VGPA and found that 40 cases (28.6%) were associated with squamous or glandular intraepithelial neoplasia. Moreover, to date, various lesions have been described in at least 12 out of 173 cases, including squamous carcinoma, glandular carcinoma, adenosquamous carcinoma and small cell carcinoma (14,(21)(22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature

et al. 2015

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Abstract. To investigate the clinicopathological features, management and prognosis of villoglandular papillary adenocarcinoma (VGPA) of the uterine cervix, the current study presents 4 cases of VGPA of the uterine cervix. The median age of the patients was 55 years (range, 47-70 years), with all 4 patients presenting with stage Ib disease. Human papillomavirus (HPV) infection was detected in 3 patients; this was mainly HPV-16. No history of oral contraceptive use was found in these cases. While 2 of the patients underwent a radical hysterectomy with bilateral salpingo-oophorectomy plus bilateral pelvic lymphadenectomy, 1 patient underwent a radical hysterectomy with bilateral pelvic lymphadenectomy and the remaining patient received a simple total hysterectomy plus post-operative radiotherapy. Of these patients, only 1 had been correctly diagnosed pre-operatively. In 2 patients, the biopsy results had been interpreted as cervical adenocarcinoma, and in the third, the biopsy result was of cervical intraepithelial neoplasia. All 4 patients presented with cervical wall invasion, including invasion of the inner two-thirds in 1 patient. No lymphovascular space invasion or lymph node metastasis was detected. The follow-up time ranged from 49 to 83 months (median, 64 months), and the patients are currently alive and well, with no evidence of recurrent disease. Taking these results as a whole, VGPA is an uncommon type of cervical adenocarcinoma, characterized by its excellent prognosis. HPV infection is associated with the molecular pathogenesis of VGPA, while oral contraceptive use can be excluded. As the disease has a low pre-operative diagnostic accuracy, frequent cervical wall invasion and concomitant lesions, conservative treatment strategies should be carefully considered.

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Section: Discussionmentioning

confidence: 99%

Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature

et al. 2015

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“…Although stromal invasion was identified in 8 of 13 cases, no deaths from tumor were described in this or another study of an additional 24 patients (43). However, occasional cases display a conventional cribriform or glandular pattern confined to the deep stromal interface, and four cases with greater cytologic atypia and nodal spread have been reported (13,44,45), emphasizing the importance of a complete histologic examination.…”

Section: Villoglandular Carcinomamentioning

confidence: 99%

Glandular Lesions of the Uterine Cervix

Zaino

2000

Modern Pathology

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“…Both squamous cell carcinoma situ and ADK VG were described in three cases (3) and both invasive squamous cell carcinoma and ADK VG in two cases (5,6). In our case, HSIL was co-existed with ADK VG in an endocervical polyp.…”

Section: Discussionmentioning

confidence: 49%

“…In the literature, cases with long follow-up periods and underwent cervical conization have been reported only (3,4,9). Most of the authors had a radical surgical approach and in some cases, para-aortic lymph node dissection (5,6,10). The advantage of hysterectomy compared to conservative treatment is not requiring long-term clinical follow-up (3).…”

Section: Discussionmentioning

confidence: 99%

Villoglandulary papillary adenocarcinoma co-existing with high-grade squamous intraepitelial lesion; arising from an endocervical polyp

Fındık

Görkemli

2017

Electron J Gen Med

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Adenocarcinomas account for 10-20% of invasive cervical carcinomas. The villoglandular papillary adenocarcinoma has been recognized as a subtype of mucinous adenocarcinoma and identified as a distinctive histological entity from the usual invasive adenocarcinomas of the uterine cervix. We report a new case of villoglandulary papillary adenocarcinoma, which was peculiar because of its association with a co-existing high grade squamous intraepithelial lesion and arising from an endocervical polyp. Excellent prognosis of isolated villoglandulary papillary adenocarcinoma is important in terms of making differential diagnosis from other adenocarcinomas and eliminating unnecessary aggressive treatments. It is also important to keep in mind for pathologists since it allows them to examine endocervical polyps that we often encounter in daily life and shows that malignant tumoral lesions can develop from polyps.

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Adenocarcinoma of the Uterine Cervix with Predominantly Villogladular Papillary Growth Pattern

Cited by 59 publications

References 0 publications

Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature

Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature

Glandular Lesions of the Uterine Cervix

Villoglandulary papillary adenocarcinoma co-existing with high-grade squamous intraepitelial lesion; arising from an endocervical polyp

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