Addressing the selective role of distinct prefrontal areas in response suppression: A study with brain tumor patients

Arbula, Sandra; Pacella, Valentina; Pellegrin, Serena De; Rossetto, Marta; Denaro, Luca; D’Avella, Domenico; Puppa, Alessandro Della; Vallesi, Antonino

doi:10.1016/j.neuropsychologia.2017.04.018

Cited by 24 publications

(21 citation statements)

References 73 publications

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“…During acquisition and extinction, we also observed reduced left iFG activation in ATO REN relative to ATO NoREN, and relative to PLAC REN during acquisition. Left iFG appears to have a role in response inhibition too, as shown in studies with human lesion patients performing a Go–NoGo task (Swick et al, 2008), one of which attributed the observed deficit to decisional rather than inhibitory processes (Arbula et al, 2017). A different hypothesis posits that left iFG is part of a network of frontal lobe subsystems that detect and resolve incompatible stimulus representations (Novick, 2005), suggesting that left iFG has a role in conflict resolution.…”

Section: Discussionmentioning

confidence: 90%

Effects of Noradrenergic Stimulation Upon Context-Related Extinction Learning Performance and BOLD Activation in Hippocampus and Prefrontal Cortex Differ Between Participants Showing and Not Showing Renewal

Lissek

Klass

Tegenthoff

2019

Front. Behav. Neurosci.

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While the neural structures mediating context-related renewal of extinction are well established, the neurotransmitter systems processing renewal remain elusive. Noradrenergic stimulation before extinction improved learning, but did not alter renewal. Since context processing already during initial conditioning can influence renewal, in this fMRI study we investigated how noradrenergic stimulation by a single dose of atomoxetine (ATO) before initial acquisition of a context-related predictive-learning task affects subsequent learning and renewal in humans. ATO participants showing contextual renewal (REN) exhibited a selective extinction learning deficit compared to placebo (PLAC) and ATO participants lacking renewal (ATO NoREN), probably owing to formation of more stable associations during acquisition. New learning and retrieval during the extinction phase as well as initial acquisition were unimpaired. In ATO REN, higher activation in right inferior frontal gyrus (iFG) during acquisition may have supported the formation of more stable associations, while reduced activation in hippocampus and left iFG during extinction was associated with impaired context encoding and response inhibition. During recall, ATO REN showed reduced overall context-dependent renewal associated with higher activation in medial PFC and right hippocampus. The results demonstrate the importance of noradrenergic processing in inferior frontal cortex and hippocampus for human extinction learning, but not necessarily initial conditioning. Since an identical atomoxetine treatment evoked diverging blood-oxygen level dependent (BOLD) activation patterns in REN and NoREN participants, the effect is presumably related to the participants’ preferred processing strategies that may have recruited differentially interconnected networks in which noradrenergic stimulation produced diverging consequences. In the ATO REN group, probably an additive effect of their preferred processing strategy, which pre-activated the noradrenergic system, and the experimental treatment caused a shift beyond the optimal working range of the noradrenergic system, thus modulating BOLD activation in a way that impaired extinction learning and recall.

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Section: Discussionmentioning

confidence: 90%

Effects of Noradrenergic Stimulation Upon Context-Related Extinction Learning Performance and BOLD Activation in Hippocampus and Prefrontal Cortex Differ Between Participants Showing and Not Showing Renewal

Lissek

Klass

Tegenthoff

2019

Front. Behav. Neurosci.

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“…Although the same authors conducted the analysis, there existed slight differences from Jimura et al ( 2014 ) regarding the brain activation and the across-subject correlation, presumably due to differences in update versions of OS (MS Windows), Matlab and SPM8. However, as reported previously, activations were observed in multiple areas including the inferior frontal gyrus, pre-supplementary motor area, and temporo-parietal junction and anterior insula (Konishi et al, 1998 , 1999 ; Garavan et al, 1999 ; de Zubicaray et al, 2000 ; Liddle et al, 2001 ; Menon et al, 2001 ; Rubia et al, 2001 ; Bunge et al, 2002 ; Durston et al, 2002a , b ; Mostofsky et al, 2003 ; Hester et al, 2004 ; Kelly et al, 2004 ; Matsubara et al, 2004 ; Brass et al, 2005 ; Aron and Poldrack, 2006 ; Chambers et al, 2006 , 2009 ; Li et al, 2006 , 2008 ; Leung and Cai, 2007 ; Sumner et al, 2007 ; Nakata et al, 2008 ; Zheng et al, 2008 ; Cai and Leung, 2009 ; Chao et al, 2009 ; Chikazoe et al, 2009a , b ; Sharp et al, 2010 ; van Gaal et al, 2010 ; Zandbelt and Vink, 2010 ; Boecker et al, 2011 ; Arbula et al, 2017 ). Correlations were also calculated between the SSRTs and the brain activity (STOP minus GO) in the 3rd to 12th runs (Figure 2C , see Supplementary Figure S1 for whole-brain slices).…”

Section: Resultsmentioning

confidence: 99%

Within-Subject Correlation Analysis to Detect Functional Areas Associated With Response Inhibition

Yamasaki

Ogawa

Osada

et al. 2018

Front. Hum. Neurosci.

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Functional areas in fMRI studies are often detected by brain-behavior correlation, calculating across-subject correlation between the behavioral index and the brain activity related to a function of interest. Within-subject correlation analysis is also employed in a single subject level, which utilizes cognitive fluctuations in a shorter time period by correlating the behavioral index with the brain activity across trials. In the present study, the within-subject analysis was applied to the stop-signal task, a standard task to probe response inhibition, where efficiency of response inhibition can be evaluated by the stop-signal reaction time (SSRT). Since the SSRT is estimated, by definition, not in a trial basis but from pooled trials, the correlation across runs was calculated between the SSRT and the brain activity related to response inhibition. The within-subject correlation revealed negative correlations in the anterior cingulate cortex and the cerebellum. Moreover, the dissociation pattern was observed in the within-subject analysis when earlier vs. later parts of the runs were analyzed: negative correlation was dominant in earlier runs, whereas positive correlation was dominant in later runs. Regions of interest analyses revealed that the negative correlation in the anterior cingulate cortex, but not in the cerebellum, was dominant in earlier runs, suggesting multiple mechanisms associated with inhibitory processes that fluctuate on a run-by-run basis. These results indicate that the within-subject analysis compliments the across-subject analysis by highlighting different aspects of cognitive/affective processes related to response inhibition.

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“…Specifically, explicit timing is usually associated with the supplementary motor area, basal ganglia, cerebellum and right inferior frontal and parietal cortices (Coull and Nobre, 2008 ; Wiener et al, 2010 ). Implicit timing, when measured through the variable foreperiod effect, has been linked to the functioning of the right lateral prefrontal cortex (Arbula et al, 2017 ) and at least in one occurrence also of the left one (Triviño et al, 2010 ), whereas sequential effects have been related to the motor/premotor circuitry (Vallesi et al, 2007a ) and left subcortical structures (Triviño et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Dissociating Explicit and Implicit Timing in Parkinson’s Disease Patients: Evidence from Bisection and Foreperiod Tasks

Mioni

Capizzi

Vallesi

et al. 2018

Front. Hum. Neurosci.

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A consistent body of literature reported that Parkinson’s disease (PD) is marked by severe deficits in temporal processing. However, the exact nature of timing problems in PD patients is still elusive. In particular, what remains unclear is whether the temporal dysfunction observed in PD patients regards explicit and/or implicit timing. Explicit timing tasks require participants to attend to the duration of the stimulus, whereas in implicit timing tasks no explicit instruction to process time is received but time still affects performance. In the present study, we investigated temporal ability in PD by comparing 20 PD participants and 20 control participants in both explicit and implicit timing tasks. Specifically, we used a time bisection task to investigate explicit timing and a foreperiod task for implicit timing. Moreover, this is the first study investigating sequential effects in PD participants. Results showed preserved temporal ability in PD participants in the implicit timing task only (i.e., normal foreperiod and sequential effects). By contrast, PD participants failed in the explicit timing task as they displayed shorter perceived durations and higher variability compared to controls. Overall, the dissociation reported here supports the idea that timing can be differentiated according to whether it is explicitly or implicitly processed, and that PD participants are selectively impaired in the explicit processing of time.

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Addressing the selective role of distinct prefrontal areas in response suppression: A study with brain tumor patients

Cited by 24 publications

References 73 publications

Effects of Noradrenergic Stimulation Upon Context-Related Extinction Learning Performance and BOLD Activation in Hippocampus and Prefrontal Cortex Differ Between Participants Showing and Not Showing Renewal

Effects of Noradrenergic Stimulation Upon Context-Related Extinction Learning Performance and BOLD Activation in Hippocampus and Prefrontal Cortex Differ Between Participants Showing and Not Showing Renewal

Within-Subject Correlation Analysis to Detect Functional Areas Associated With Response Inhibition

Dissociating Explicit and Implicit Timing in Parkinson’s Disease Patients: Evidence from Bisection and Foreperiod Tasks

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