Additively manufactured Bi-functionalized bioceramics for reconstruction of bone tumor defects

Belluomo, Ruggero; Khodaei, Azin; Yavari, Saber Amin

doi:10.1016/j.actbio.2022.08.042

Cited by 16 publications

(7 citation statements)

References 178 publications

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“…Chemotherapy is a method of treating malignant tumors through the use of chemotherapeutic agents, which are applied systemically or locally to kill or control tumor cells and stop tumor growth. [100] Although chemotherapy plays a key role in cancer treatment, chemotherapeutic drugs themselves have some problems such as instability, poor solubility, low absorption efficiency and non-specific targeting of cancer cells. [101] To overcome these problems, nanocarriers based on LDH were introduced to effectively improve the stability, solubility, and controlled release of drugs.…”

Section: Chemotherapymentioning

confidence: 99%

Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

Ma,

Chen,

Qiao

2024

The Chemical Record

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Layered double hydroxides (LDH) are a class of functional anionic clays that typically consist of orthorhombic arrays of metal hydroxides with anions sandwiched between the layers. Due to their unique properties, including high chemical stability, good biocompatibility, controlled drug loading, and enhanced drug bioavailability, LDHs have many potential applications in the medical field. Especially in the fields of bioimaging and tumor therapy. This paper reviews the research progress of LDHs and their nanocomposites in the field of tumor imaging and therapy. First, the structure and advantages of LDH are discussed. Then, several commonly used methods for the preparation of LDH are presented, including co‐precipitation, hydrothermal and ion exchange methods. Subsequently, recent advances in layered hydroxides and their nanocomposites for cancer imaging and therapy are highlighted. Finally, based on current research, we summaries the prospects and challenges of layered hydroxides and nanocomposites for cancer diagnosis and therapy.

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Section: Chemotherapymentioning

confidence: 99%

Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

Ma,

Chen,

Qiao

2024

The Chemical Record

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“…Combined with AM, it can regulate pore size, pore shape, pore arrangement, and morphology to prepare multiscale porous structures suitable for cell growth. Consequently, additively manufactured calcium phosphate-based ceramics have been broadly adopted as bone regeneration materials, including hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP), and biphasic calcium phosphate (BCP), for autologous bone graft substitutes due to their remarkably bioactive and osteoinductive qualities Table lists the advantages and disadvantages, technologies, mechanical properties, and biological experiments of several major types of additively manufactured bioactive ceramics.…”

Section: Advances In Additive Manufacturing Of Bioceramic Implantsmentioning

confidence: 99%

“…Polymer or organic implants have superior biological properties but insufficient mechanical properties and induce inflammation. Similar to metals, inflammation following ion release is one of the biggest drawbacks of polymer implants. , …”

Section: Introductionmentioning

confidence: 99%

Additive Manufacturing of Bioceramic Implants for Restoration Bone Engineering: Technologies, Advances, and Future Perspectives

Zhou

Su²,

et al. 2023

ACS Biomater. Sci. Eng.

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Treating bone defects is highly challenging because they do not heal on their own inside the patients, so implants are needed to assist in the reconstruction of the bone. Bioceramic implants based on additive manufacturing (AM) are currently emerging as promising treatment options for restoration bone engineering. On the one hand, additively manufactured bioceramic implants have excellent mechanical properties and biocompatibility, which are suitable for bone regeneration. On the other hand, the designable structure and adjustable pores of additively manufactured bioceramic implants allow them to promote suitable cell growth and tissue climbing. Herein, this review unfolds to introduce several frequently employed AM technologies for bioceramic implants. After that, advances in commonly used additively manufactured bioceramic implants, including bioinert ceramic implants, bioactive ceramic implants, and bioceramic/organic composite implants, are categorized and summarized. Finally, the future perspectives of additively manufactured bioceramic implants, in terms of mechanical performance improvement, innovative structural design, biological property enhancement, and other functionalization approaches, are proposed and forecasted. This review is believed to provide some fundamental understanding and cutting-edge knowledge for the additive manufacturing of bioceramic implants for restoration bone engineering.

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“…[ 4 ] However, these materials lack antitumor properties and are not able to inhibit the proliferation and metastasis of local residual tumor cells, resulting in limited clinical treatment effects. [ 5 ] Consequently, urgent innovation is required to find more effective treatment strategies for the postoperative treatment of osteosarcoma.…”

Section: Introductionmentioning

confidence: 99%

Single‐Atom Cu Nanozyme‐Loaded Bone Scaffolds for Ferroptosis‐Synergized Mild Photothermal Therapy in Osteosarcoma Treatment

Yan,

Wu,

Tan

et al. 2024

Adv Healthcare Materials

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The rapid multiplication of residual tumor cells and poor reconstruction quality of new bone are considered the major challenges in the postoperative treatment of osteosarcoma. It is a promising candidate for composite bone scaffold which combines photothermal therapy (PTT) and bone regeneration induction for the local treatment of osteosarcoma. However, it is inevitable to damage the normal tissues around the tumor due to the hyperthermia of PTT, while mild heat therapy shows a limited effect on anti‐tumor treatment as the damage can be easily repaired by stress‐induced heat shock proteins (HSP). This study reports a new type of single‐atom Cu nanozyme‐loaded bone scaffolds, which exhibited exceptional photothermal conversion properties as well as peroxidase and glutathione oxidase mimicking activities in vitro experiments. This led to lipid peroxidation (LPO) and reactive oxygen species (ROS) upregulation, ultimately causing ferroptosis. The accumulation of LPO and ROS also contributed to HSP70 inactivation, maximizing PTT efficiency against tumors at an appropriate therapeutic temperature and minimizing the damage to surrounding normal tissues. Further, the bone scaffold promoted bone regeneration via a continuous release of bioactive ions (Ca2+, P5+, Si4+, Cu2+). The results of in vivo experiments revealed that scaffolds inhibited tumor growth and promoted bone repair.This article is protected by copyright. All rights reserved

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Additively manufactured Bi-functionalized bioceramics for reconstruction of bone tumor defects

Cited by 16 publications

References 178 publications

Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

Additive Manufacturing of Bioceramic Implants for Restoration Bone Engineering: Technologies, Advances, and Future Perspectives

Single‐Atom Cu Nanozyme‐Loaded Bone Scaffolds for Ferroptosis‐Synergized Mild Photothermal Therapy in Osteosarcoma Treatment

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