Additive effect of lithium and clonidine with 5HT1A agonists in the forced swimming test

NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test

“…This effect of lithium was significant at the doses of 30 and 100 mg/kg, whereas lower doses of lithium (5 and 10 mg/kg) had no significant antidepressant-like effect. These results are in agreement with our recent study (Ghasemi, et al, 2008) and previous studies that have shown that either acute or chronic lithium treatment decreases the immobility time in the FST alone or in combination with other antidepressant agents (Bersudsky, et al, 2007;Cryns, et al, 2007;Gould, et al, 2008;Hascoet, et al, 1994;Nixon, et al, 1994;O'Brien, et al, 2004;Redrobe and Bourin, 1999a,b;Shaldubina, et al, 2006;Silva, et al, 2008). This effect of lithium in the FST could represent a parallel to the mood stabilising action of lithium on the depressive phase of bipolar administration of lithium (10 mg/kg, i.p.)…”

NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test

“…This effect of lithium was significant at the doses of 30 and 100 mg/kg, whereas lower doses of lithium (5 and 10 mg/kg) had no significant antidepressant-like effect. These results are in agreement with our recent study (Ghasemi, et al, 2008) and previous studies that have shown that either acute or chronic lithium treatment decreases the immobility time in the FST alone or in combination with other antidepressant agents (Bersudsky, et al, 2007;Cryns, et al, 2007;Gould, et al, 2008;Hascoet, et al, 1994;Nixon, et al, 1994;O'Brien, et al, 2004;Redrobe and Bourin, 1999a,b;Shaldubina, et al, 2006;Silva, et al, 2008). This effect of lithium in the FST could represent a parallel to the mood stabilising action of lithium on the depressive phase of bipolar administration of lithium (10 mg/kg, i.p.)…”

The behavioral actions of lithium in rodent models: Leads to develop novel therapeutics

“…Two, 4, and 8 mEq/kg lithium were shown to have a small but significant effect on immobility time, and when the subactive 1 mEq/kg was administered 15 minutes before a subactive dose of the 5HT(1A) agonist gepirone, immobility time was also reduced. This adjunctive effect of lithium, which it shares (though not identically) with clonidine and quinine, has been shown for a number of different kinds of antidepressants, including SSRIs, MAOIs, tricyclic, and atypical antidepressants (Malinge et al, 1988;Bourin et al, 1991;Hascoet et al, 1994;Nixon et al, 1994;Guo et al, 1995;Bourin et al, 1996;Redrobe et al, 1998). This additive mechanism is likely to be mediated at least in part by the serotonergic system, as antidepressants specific for dopaminergic and noradrenergic transmission are not affected by lithium in this model (Nixon et al, 1994).…”

Different effects of 5-HT 1A receptor agonists and benzodiazepine anxiolytics on the emotional state of naive and stressed mice: a study using the hole-board test

“…Therefore, the effects of any remaining drug also may be excluded. Previously, stress-induced decreases in various behaviors have been widely used as animal models of depression, and the effectiveness of 5-HT 1A receptor agonists has been demonstrated in these models (Schipper et al 1991;Van Dijken et al 1992;Hascoet et al 1994). However, these previous experiments were performed under conditions in which the administered drugs remained in the body, i.e.…”

NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test

“…This effect of lithium was significant at the doses of 30 and 100 mg/kg, whereas lower doses of lithium (5 and 10 mg/kg) had no significant antidepressant-like effect. These results are in agreement with our recent study (Ghasemi, et al, 2008) and previous studies that have shown that either acute or chronic lithium treatment decreases the immobility time in the FST alone or in combination with other antidepressant agents (Bersudsky, et al, 2007;Cryns, et al, 2007;Gould, et al, 2008;Hascoet, et al, 1994;Nixon, et al, 1994;O'Brien, et al, 2004;Redrobe and Bourin, 1999a,b;Shaldubina, et al, 2006;Silva, et al, 2008). This effect of lithium in the FST could represent a parallel to the mood stabilising action of lithium on the depressive phase of bipolar administration of lithium (10 mg/kg, i.p.)…”

The behavioral actions of lithium in rodent models: Leads to develop novel therapeutics

“…Two, 4, and 8 mEq/kg lithium were shown to have a small but significant effect on immobility time, and when the subactive 1 mEq/kg was administered 15 minutes before a subactive dose of the 5HT(1A) agonist gepirone, immobility time was also reduced. This adjunctive effect of lithium, which it shares (though not identically) with clonidine and quinine, has been shown for a number of different kinds of antidepressants, including SSRIs, MAOIs, tricyclic, and atypical antidepressants (Malinge et al, 1988;Bourin et al, 1991;Hascoet et al, 1994;Nixon et al, 1994;Guo et al, 1995;Bourin et al, 1996;Redrobe et al, 1998). This additive mechanism is likely to be mediated at least in part by the serotonergic system, as antidepressants specific for dopaminergic and noradrenergic transmission are not affected by lithium in this model (Nixon et al, 1994).…”

Different effects of 5-HT 1A receptor agonists and benzodiazepine anxiolytics on the emotional state of naive and stressed mice: a study using the hole-board test

“…Therefore, the effects of any remaining drug also may be excluded. Previously, stress-induced decreases in various behaviors have been widely used as animal models of depression, and the effectiveness of 5-HT 1A receptor agonists has been demonstrated in these models (Schipper et al 1991;Van Dijken et al 1992;Hascoet et al 1994). However, these previous experiments were performed under conditions in which the administered drugs remained in the body, i.e.…”

NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test

“…This effect of lithium was significant at the doses of 30 and 100 mg/kg, whereas lower doses of lithium (5 and 10 mg/kg) had no significant antidepressant-like effect. These results are in agreement with our recent study (Ghasemi, et al, 2008) and previous studies that have shown that either acute or chronic lithium treatment decreases the immobility time in the FST alone or in combination with other antidepressant agents (Bersudsky, et al, 2007;Cryns, et al, 2007;Gould, et al, 2008;Hascoet, et al, 1994;Nixon, et al, 1994;O'Brien, et al, 2004;Redrobe and Bourin, 1999a,b;Shaldubina, et al, 2006;Silva, et al, 2008). This effect of lithium in the FST could represent a parallel to the mood stabilising action of lithium on the depressive phase of bipolar administration of lithium (10 mg/kg, i.p.)…”

The behavioral actions of lithium in rodent models: Leads to develop novel therapeutics

“…Two, 4, and 8 mEq/kg lithium were shown to have a small but significant effect on immobility time, and when the subactive 1 mEq/kg was administered 15 minutes before a subactive dose of the 5HT(1A) agonist gepirone, immobility time was also reduced. This adjunctive effect of lithium, which it shares (though not identically) with clonidine and quinine, has been shown for a number of different kinds of antidepressants, including SSRIs, MAOIs, tricyclic, and atypical antidepressants (Malinge et al, 1988;Bourin et al, 1991;Hascoet et al, 1994;Nixon et al, 1994;Guo et al, 1995;Bourin et al, 1996;Redrobe et al, 1998). This additive mechanism is likely to be mediated at least in part by the serotonergic system, as antidepressants specific for dopaminergic and noradrenergic transmission are not affected by lithium in this model (Nixon et al, 1994).…”

Different effects of 5-HT 1A receptor agonists and benzodiazepine anxiolytics on the emotional state of naive and stressed mice: a study using the hole-board test

“…Therefore, the effects of any remaining drug also may be excluded. Previously, stress-induced decreases in various behaviors have been widely used as animal models of depression, and the effectiveness of 5-HT 1A receptor agonists has been demonstrated in these models (Schipper et al 1991;Van Dijken et al 1992;Hascoet et al 1994). However, these previous experiments were performed under conditions in which the administered drugs remained in the body, i.e.…”