Additional antiprotozoal flavonol glycosides of the aerial parts of <i>Helianthemum glomeratum</i>

Calzada, Fernando; Alanís, Alma Delia

doi:10.1002/ptr.2031

Cited by 40 publications

(30 citation statements)

References 18 publications

(14 reference statements)

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“…The drug of choice in the treatment of giardiasis is metronidazole (Flagyl), which is among the nitroimidazole derivatives and effective on anaerobic bacteria and protozoa. Other drugs used to treat giardiasis are furazolidone and quinacrine (Harris et al 2001a;Calzada and Alanis 2007). Metronidazole has been used for several decades in the treatment of protozoan, bacterial and fungal infections; nonetheless, there have been some reports regarding the carcinogenic and teratogenic effects on laboratory rats and drug resistance to some isolates of Giardia.…”

Section: Introductionmentioning

confidence: 99%

Effect of olive leaf, Satureja khuzestanica, and Allium sativum extracts on Giardia lamblia cysts compared with metronidazole in vitro

et al. 2015

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Giardia lamblia is one of the common causes of worldwide diarrhea in children. Appropriate medicinal treatment for giardiasis is available but there are some evidences of drug resistance, insufficient efficacy, and unpleasant side effects. In order to reach a more natural drug with suitable efficacy and the lowest side effects, the effects of the hydroalcoholic extracts of olive leaf, Satureja khuzestanica, and Allium sativum on G. lamblia cysts were evaluated in vitro, as well as antigiardial effect of the extracts was compared with metronidazole as the drug of choice. 2 and 5 mg of the plants extracts and powder of metronidazole 250 mg pills were added to 1 ml of G. lamblia cysts suspension (containing 5,000 cyst/ml normal saline), and the percentages of bioavailability of G. lamblia cysts were examined at the 2nd and 4th h after exposure and in 4 and 37°C temperatures using eosin 0.1 % and a haemocytometer. The data were analyzed by multiway ANOVA test, Tukey's test, and the SPSS software, version 18. The examinations demonstrated that olive leaf extract had the most fatality rate on G. lamblia cysts in vitro (37.90 ± 7.01 %), followed by the extract of S. khuzestanica (32.52 ± 9.07 %). Metronidazole 250 mg pills had relatively effective fatality rate on G. lamblia cysts in vitro (28.75 ± 10.30 %), whereas A. sativum (garlic) had the lowest fatality effect on G. lamblia cysts in vitro (22.65 ± 10.47 %). With respect to higher fatality effect of olive leaf and S. khuzestanica extracts compared with metronidazole in vitro, these plants can be used as suitable candidates to make new antigiardial drugs with low side effects and without drug resistance in the treatment of giardiasis in children.

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Section: Introductionmentioning

confidence: 99%

Effect of olive leaf, Satureja khuzestanica, and Allium sativum extracts on Giardia lamblia cysts compared with metronidazole in vitro

et al. 2015

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“…It has been reported that astragalin and kaempferol-3-O-glucuronide isolated from Vahlia capensis and kaempferol-3-O-glucuronide from Rubus ulmifolius showed antibacterial activity [17]. Antioxidant [6][7][8], antiprotozoal [9], hepatoprotective [18] and glycation inhibitory effects [19] were also observed with these two bioactive compounds. Despite reports on the use of folk medicine together with reports on medicinal potentials of this plant, information on the hepatoprotective activity is unavailable to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 93%

“…India, the abode of Ayurvedic system of medicine, assigns much importance to the pharmacological aspects of many plants. Hepatoprotective effect of some plants like Spirulina maxima [5], Eclipta alba [6], Boehmeria nivea [7], Cichorium intybus [8], Picrorhiza kurroa [9], Maydis stigma (10), Gmelina arborea Roxb. (11) and Manilkara zapota [12] etc.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of <i>Alpina nigra</i> Leaves Extract in Mouse Liver Injury Induced by Carbon Tetrachloride

Islam¹,

Chowdhury²,

Uddin³

et al. 2016

J. Sci. Res.

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The present study was aimed to evaluate the hepatoprotective activity of methanol extract against carbon tetrachloride (CCl 4 ) induced hepatic damage in rats. CCl 4 caused liver damage in rats manifested by significant rise in serum enzyme levels. To examine the effect of the extract male albino rats were used and extract was administered orally at a dose of 300 mg/kg once daily. The results obtained showed that there were reductions in the activities of serum SGOT, SGPT, ALP, total protein, total bilirubin from 97.67±1.78, 275.67±2.86, 934 ± 1.41, 1.13±0.227 and 7.50±0.707 in animals treated with toxic doses of CCl 4 to 78.33±1.08, 53±1.41, 870±0.707, 0.67±0.04 and 6.47±0.356 in animal treated with extract before CCl 4 intoxication. The extract could also repair the abnormal lipid profile. From these results, it is concluded that methanol extract of Alpina nigra leaves has hepatoprotective activity in CCl 4 -induced hepatic damage in rats.

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“…The more glycosyl of gracillin indicates a stronger ability of the chemical to be dissolved in body fluid resulting in much more easily interact with its target in the parasites. Therefore, it is postulated that the more sugar moiety might be responsible for the higher anthelmintic efficacy of gracillin (Calzada and Alanis 2007).…”

Section: Samplementioning

confidence: 99%

Anthelmintic activity of steroidal saponins from Dioscorea zingiberensis C. H. Wright against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus)

Wang

Jiang

et al. 2010

Parasitol Res

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Dactylogyrus intermedius is one of the most pathogenic monogenean parasites on the gills of captive fish and can cause serious problem in aquaculture. To attempt controlling this parasite and explore novel potential antiparasitic agents, the present study was designed to investigate the anthelmintic activity of Dioscorea zingiberensis C. H. Wright against D. intermedius in goldfish under in vivo conditions. Bioactivity-guided fractionation and isolation of the compounds responsible for anthelmintic activity was carried out with the ethanolic extract yielding two bioactive compounds. Using MS, (1)H NMR, (13)C NMR spectroscopic analyses, the two compounds were identified as trillin and gracillin. The results of in vivo anthelmintic efficacy assay showed that the 48-h median effective concentrations (EC(50)) are 26.48 mg L(-1) for trillin and 0.18 mg L(-1) for gracillin. The 48-h acute toxicity tests (LD(50)) of trillin and gracillin were found to be 73.11 and 1.40 mg L(-1) for goldfish, respectively. The resulting therapeutic indices for the two active compounds are 2.76 and 7.78, respectively. These data confirmed that both trillin and gracillin are effective against D. intermedius, and the gracillin exhibits more interesting perspectives for the development of a candidate antiparasitic agent.

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Additional antiprotozoal flavonol glycosides of the aerial parts of Helianthemum glomeratum

Cited by 40 publications

References 18 publications

Effect of olive leaf, Satureja khuzestanica, and Allium sativum extracts on Giardia lamblia cysts compared with metronidazole in vitro

Effect of olive leaf, Satureja khuzestanica, and Allium sativum extracts on Giardia lamblia cysts compared with metronidazole in vitro

Protective Effect of <i>Alpina nigra</i> Leaves Extract in Mouse Liver Injury Induced by Carbon Tetrachloride

Anthelmintic activity of steroidal saponins from Dioscorea zingiberensis C. H. Wright against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus)

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