Addition of Low-Dose Methotrexate to Infliximab in the Treatment of a Patient With Severe, Recalcitrant Pustular Psoriasis

Infectious Urticaria with Purpura: A Mild Subtype of Urticarial Vasculitis?

“…Newland et al (7) treated a 44-year-old Caucasian woman with the von Zumbusch type pustular psoriasis with 5 mg/kg infliximab, 100 mg cyclosporin and 150 mg bexarotene and observed a rapid clearing of pustules and erythema, normalization of fever, leukocytosis, erythrocyte sedimentation rate and CRP levels within 24 h. Elewski (6) described a 39-year-old Caucasian man with generalized pustular psoriasis who cleared rapidly after treatment with 5 mg/kg infliximab, 25 mg/ week MTX, 75 mg/day acitretin and 20 mg/day prednisolone. An additional case report describes favourable responses to infliximab in pustulosis palmo-plantaris (8). Our data further support the conclusion that infliximab produces a rapid amelioration of pustular psoriasis (cases 1 and 2).…”

The Efficacy of Biologic Therapy for the Management of Palmoplantar Psoriasis and Palmoplantar Pustulosis: A Systematic Review

“…Case reports and case series describe effective treatment of PPP with etanercept, infliximab, and ustekinumab [ 20 , 29 , 31 , 32 , 46 – 50 , 53 , 54 ]. Multiple reports of treatment with infliximab describe a period of initial improvement with eventual recurrence (Tables 3 , 4 ) [ 36 , 38 , 40 ].…”

Infliximab for the treatment of psoriasis: Clinical experience at the State University of New York at Buffalo

“…Patients received a mean total number of treatments of 12 (range, [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Patients were followed up for a minimum of 4 months and maximum of 33 months (median, 22 months).…”