RETRACTED: Adding l-carnitine to clomiphene resistant PCOS women improves the quality of ovulation and the pregnancy rate. A randomized clinical trial

Ismail, Alaa M.; Hamed, Ali Hassan; Saso, Srdjan; Thabet, Hossam H.

doi:10.1016/j.ejogrb.2014.06.008

Cited by 53 publications

(64 citation statements)

References 21 publications

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“…This was in agreement with the study of Ismail et al, as they reported that there was a highly statistical significant difference (P<0.0001) between the two groups, in which the L-carnitine group had a mean number of follicles more than the placebo group [10] . This was also in agreement with the study of Latifian et al, as they reported that there was a statistical significant difference (P<0.05) in the favour of the women that received L-carnitine [6] .…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

“…The main outcome measures were the ovulation rate and cumulative pregnancy rate. A previous study reported that the ovulation and cumulative pregnancy rates were 64.4% versus 17.4% and 51.5% versus 5.8% in PCO patients receiving L-carnitine with clomiphene citrate or clomiphene citrate alone, respectively [10] .…”

Section: Sample Size Calculationmentioning

confidence: 95%

“…A study by Celik et al, in 2017 showed that the women with PCOS had significantly lower L-carnitine levels than those of the healthy controls [9] . Another study by Ismail et al, depicted that combined L-carnitine and clomiphene citrate resulted in significant improvement in both ovulation and cumulative pregnancy rates in women with clomiphene-resistant PCOS [10] .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

L-Carnitine and Clomiphene Citrate for induction of ovulation in women with Polycystic Ovary Syndrome : Randomized controlled trial

Kortam¹,

Abdelrahman

Fateen

2020

Evidence Based Women's Health Journal

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Aim:The aim of the study was to assess the efficacy of adding L-carnitine to clomiphene citrate for increasing the ovulation and the pregnancy rate in women with PCOS. The primary outcome was the ovulation rate and the secondary outcome was the pregnancy rate. Materials and Methods: This study was a randomized controlled clinical trial that was conducted on 94 women who attended at the Obstetrics and Gynecology Outpatient Infertility Clinic at Ain-Shams University Maternity Hospital, and they were diagnosed with PCOS according to the Rotterdam Criteria (11). The women were distributed randomly into two equal groups; Group L (n=47) received 100 mg of clomiphene citrate plus 3 gm of L-carnitine orally from day 3 to day 7 of the cycle with continuation of L-carnitine till the day of pregnancy test and Group C (n=47) received 100 mg of clomiphene citrate orally from day 3 to day 7 of the cycle. Results: There was a significant difference (P<0.05) between the two groups regarding the ovulation rate (Group L: 70.2%; Group C: 44.7%). There was no significant difference (P>0.05) between the two groups regarding the pregnancy rate (Group L: 8.5%; Group C: 6.4%). There was a highly significant difference (P<0.01) between the two groups as regards to the number of mature follicles (Group L: 1.6 ± 1.2; Group C: 0.8 ± 0.7), the days needed till hCG injection (Group L: 12.2 ± 1.5; Group C: 14.0 ± 1.8), the Endometrial thickness (Group L: 10.4 ± 1.2 mm; Group C: 9.1 ± 0.8 mm). There was no significant difference (P>0.05) between the two groups regarding the level of progesterone after 8 days from the hCG injection. Conclusion: L-carnitine added to clomiphene citrate for induction of ovulation in PCOS women had a significant effect on the ovulation rate, but it didn't have a significant effect on the pregnancy rate when compared to clomiphene citrate alone.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Sample Size Calculationmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

L-Carnitine and Clomiphene Citrate for induction of ovulation in women with Polycystic Ovary Syndrome : Randomized controlled trial

Kortam¹,

Abdelrahman

Fateen

2020

Evidence Based Women's Health Journal

View full text Add to dashboard Cite

show abstract

“…There were 33 RCTs comprising a total of 4349 women with WHO group II anovulation, undergoing 7210 treatment cycles. Of the 33 included studies, participants were women with PCOS (without CC resistance) in 25 studies, women with CC‐resistant PCOS in five studies, women with WHO group II anovulation (with or without PCOS) in two studies and women with WHO group II anovulation (without PCOS) in one study. The characteristics of these 33 included studies are listed in Table .…”

Section: Resultsmentioning

confidence: 99%