Adding “hemodynamic and fluid leads” to the ECG. Part I: The electrical estimation of BNP, chronic heart failure (CHF) and extracellular fluid (ECF) accumulation

Skrabal, F.; Pichler, Georg P.; Gratze, Gerfried; Holler, Albert

doi:10.1016/j.medengphy.2014.03.015

Cited by 11 publications

(14 citation statements)

References 46 publications

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“…[19,24,25] Additionally, changes in body composition have been recently shown to be associated with abdominal aortic aneurysm growth after endovascular treatment. [26] The CombynECG uses segmental bioimpedance including a routine ECG that can also reliably assess body composition [20,21] and grants insight to hemodynamic parameters such as the aortofemoral pulse wave velocity [27]. Based on these premises it appears very reasonable that the device can facilitate AAA diagnosis and provide a non-invasive screening tool.…”

Section: Discussionmentioning

confidence: 99%

“…In the present work we present a potential solution in the quest for radiation-and contrast-enhancementfree diagnostic tools in the form of a non-invasive cardiovascular screening device. The added bene t of the device is the absent inter-rater variation of ultrasound studies and its simultaneous assessment of other physiological features and pathologies such as body composition [20] or heart failure [21]. Ultimately, promising results were discovered with a device that was not speci cally designed for the research question at hand.…”

Section: Discussionmentioning

confidence: 99%

“…Details of the CombynECG measurement protocol and nal output have been previously described elsewhere. [20,21] In total, it takes between 10 and 15 minutes to run the standard CombynECG protocol. Additionally, participants blood pressure and handgrip strength (on the dominant side) were measured three consecutive times.…”

Section: Combynecgmentioning

confidence: 99%

“…Recently, bioimpedance has re-emerged as an interesting non-invasive alternative to conventional imaging techniques as it has shown to be able to be used for large scale cardio-vascular and kidney disease screenings [20,21] or even for the prediction of arterio-venous stula maturation [22]. The CombynECG is a certi ed medical device that combines a standard 12 channel ECG and bioimpedance analysis functions combined with additional features such as blood pressure and handgrip strength measurements.…”

Section: Introductionmentioning

confidence: 99%

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Detection of Abdominal Aortic Aneurysms via Bioelectrical Impedance Analysis – a pilot study

Hofmann

Shoumariyeh

Domenig

et al. 2023

Preprint

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Objective: To assess the feasibility of abdominal aortic aneurysm (AAA) detection based on parameters obtained from segmental bioimpedance measurements. Design: Pilot study Methods: In this single center exploratory pilot study, measurements were conducted in three different cohorts: patients with AAA, end stage renal disease patients without AAA, and healthy controls. The device used in the study, CombynECG, is an open market accessible device for segmental bioelectrical impedance analysis. The data was preprocessed and used to establish 4 different machine learning models on a randomized training sample. Each model was then evaluated on a test sample. Results: The total sample included 22 patients with AAA, 16 chronic kidney disease patients, and 23 healthy controls. All four models showed strong predictive performance in the test partitions. Specificity ranged from 71.4 to 100 %, while sensitivity ranged from 66.7 to 100 %. The best performing model had 100% accuracy during classification on a test sample. Additionally, an exploratory analysis to approximate the maximum AAA diameter was conducted. An association analysis revealed potential variables that might hold predictive ability for aneurysm extent. Conclusion: AAA detection via bioelectrical impedance analysis is technically feasible and appears to be a promising technology for large scale clinical studies as well as routine clinical screening assessment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Combynecgmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Detection of Abdominal Aortic Aneurysms via Bioelectrical Impedance Analysis – a pilot study

Hofmann

Shoumariyeh

Domenig

et al. 2023

Preprint

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“…Segmental multifrequency bioimpedance analysis (BIA) is also an alternative approach for measuring AppMM 5,6 . Its inclusion into the 12‐channel electrocardiogram (ECG) 7 provides, without time delay, measurement of AppMM and hydration status and important clues for the diagnosis of CHF 7 —and this with a methodology that is performed routinely in internal medicine. We have shown that the measurement of AppMM by segmental multifrequency BIA can give erroneous results in patients with congestion 7 .…”

Section: Introductionmentioning

confidence: 99%

Sizing and mending of appendicular muscle mass for hydration during the 12‐lead electrocardiogram: True incidence of sarcopenia in heart failure

Skrabal,

Heymsfield,

Skrabal

et al. 2024

J cachexia sarcopenia muscle

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BackgroundOur aim was to develop and evaluate a method for the measurement of muscle mass during the 12‐channel electrocardiogram (ECG), to determine the incidence of sarcopenia in patients with overhydration and to correct it for congestion.MethodsA 12‐channel ECG that simultaneously provided multifrequency segmental impedance data was used to measure total body water (TBW), extracellular water (ECW), ECW/TBW ratio and appendicular muscle mass (AppMM), validated by whole‐body dual‐energy X‐ray absorptiometry. The mean ECW/TBW ratio was 0.24 ± 0.018 (SD) and 0.25 ± 0.016 for young (age range 20–25 years) healthy males (n = 77) and females (n = 88), respectively. The deviation of the ECW/TBW ratio from this mean was used to correct AppMM for excess ECW (‘dry AppMM’) in 869 healthy controls and in 765 patients with chronic heart failure (CHF) New York Heart Association classes II–IV. The association of AppMM and dry AppMM with grip strength was also examined in 443 controls and patients.ResultsWith increasing N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), a continuous decline of AppMM indices is observed, which is more pronounced for dry AppMM indices (for males with NT‐proBNP < 125 pg/mL: AppMM index mean = 8.4 ± 1.05, AppMM index dry mean = 8.0 ± 1.46 [n = 201, P < 0.001]; for females with NT‐proBNP < 150 pg/mL: AppMM index mean = 6.4 ± 1.0, AppMM index dry mean = 5.8 ± 1.18 [n = 198, P < 0.001]; for males with NT‐proBNP > 1000 pg/mL: AppMM index mean = 7.6 ± 0.98, AppMM index dry mean = 6.2 ± 1.11 [n = 137, P < 0.001]; and for females with NT‐proBNP > 1000 pg/mL: AppMM index mean = 5.9 ± 0.96, AppMM index dry mean = 4.8 ± 0.94 [n = 109, P < 0.001]). The correlation between AppMM and upper‐body AppMM and grip strength (r‐value) increased from 0.79 to 0.83 (P < 0.001) and from 0.80 to 0.84 (P < 0.001), respectively, after correction (n = 443). The decline of AppMM with age after correction for ECW is much steeper than appreciated, especially in males: In patients with CHF and sarcopenia, the incidence of sarcopenia may be up to 30% higher after correction for ECW excess according to the European (62% vs. 57%, for males, and 43% vs. 31%, for females) and Foundation for the National Institutes of Health (FNIH) (56% vs. 46%, for males, and 54% vs. 38%, for females) consensus guidelines.ConclusionsThe incidence of sarcopenia in CHF as defined by the European Working Group on Sarcopenia and FNIH consensus may be up to 30% higher after correction for ECW excess. This correction improves the correlation between muscle mass and strength. The presented technology will facilitate, on a large scale, screening for sarcopenia, help identify mechanisms and improve understanding of clinical outcomes.

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Systems, sensors, and devices in personal healthcare applications

Mühlsteff

Kate

Bonomi

et al. 2022

Personalized Health Systems for Cardiovascular Disease

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Adding “hemodynamic and fluid leads” to the ECG. Part I: The electrical estimation of BNP, chronic heart failure (CHF) and extracellular fluid (ECF) accumulation

Cited by 11 publications

References 46 publications

Detection of Abdominal Aortic Aneurysms via Bioelectrical Impedance Analysis – a pilot study

Detection of Abdominal Aortic Aneurysms via Bioelectrical Impedance Analysis – a pilot study

Sizing and mending of appendicular muscle mass for hydration during the 12‐lead electrocardiogram: True incidence of sarcopenia in heart failure

Systems, sensors, and devices in personal healthcare applications

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