2017
DOI: 10.18632/aging.101180
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Abstract: Maximum lifespan varies by two orders of magnitude across mammals. How such divergent lifespans have evolved remains an open question, with ramifications that may potentially lead to therapies for age-related diseases in humans. Several species of microbats as well as the naked mole-rat live much longer than expected given their small sizes, show reduced susceptibility to neoplasia, and largely remain healthy and reproductively capable throughout the majority of their extended lifespans. The convergent evoluti… Show more

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Cited by 8 publications
(5 citation statements)
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References 50 publications
(55 reference statements)
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“…The electron transport chain proteins are the machinery for generating ATP and changes in these molecules could be postulated to alter the efficiency of intracellular energy production. In brain mitochondria we also found significant differences in two RAS oncogene family RAB proteins 1B and 14, these are GTPases involved in intracellular trafficking between Golgi and endosomes [26,27], there is accumulating evidence that differential regulation of tumour pathway proteins occurs also in species of bats [2830]. In the skeletal muscle we found many mitochondria specific protein differences.…”
Section: Discussionmentioning
confidence: 68%
“…The electron transport chain proteins are the machinery for generating ATP and changes in these molecules could be postulated to alter the efficiency of intracellular energy production. In brain mitochondria we also found significant differences in two RAS oncogene family RAB proteins 1B and 14, these are GTPases involved in intracellular trafficking between Golgi and endosomes [26,27], there is accumulating evidence that differential regulation of tumour pathway proteins occurs also in species of bats [2830]. In the skeletal muscle we found many mitochondria specific protein differences.…”
Section: Discussionmentioning
confidence: 68%
“…ADAMTS9 is a pleiotropic gene that belongs to a large, diversified family of ADAMTS genes and has been implicated in several crucial female reproductive processes, namely: ovulation, implantation, placentation and parturition (Russell et al., 2015). ADAMTS9 is also a novel tumour suppressor (Du et al., 2013) and has undergone strong selection for increased longevity in a number of small‐bodied mammal lineages (Lambert & Portfors, 2017). This is particularly interesting in our context, as Tasmanian devils have a short lifespan (maximum 5 years in the wild) in comparison to other mammals of their size and show unusually high vulnerability to tumours (Griner, 1979).…”
Section: Discussionmentioning
confidence: 99%
“…Differences have been reported in DNA repair capacity via a positive selection for DNA repair enzymes, such as Ku80 that is involved in the repair of DNA double strand breaks [ 64 ]. Furthermore, insulin signaling is downregulated during periods of hibernation in bats, which has been linked to an overall reduction in cellular growth and proliferation in bats and other cancer resistant vertebrates [ 67 , 68 , 69 , 70 , 71 ].…”
Section: Potential Protective Mechanisms Responsible For Cancer-resis...mentioning
confidence: 99%