2008
DOI: 10.1111/j.1365-2826.2008.01735.x
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Abstract: Pregnancy and lactation have been shown over the last 40 years to be physiological states in which hypothalamic-pituitary-adrenal (HPA) axis responses to stressors are markedly attenuated (1, 2). These phenomena provide an unequalled opportunity to understand natural mechanisms that reduce stress responses, and the prospect of new therapies for stress-related disorders.The (HPA) axis comprises the corticotropin-releasing factor (CRF) neurones in the parvocellular paraventricular nucleus (pPVN), which also vari… Show more

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Cited by 242 publications
(185 citation statements)
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References 160 publications
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“…Even during the first week of late pregnancy, fGC levels already averaged~200 ng/g feces and levels of up to~400 ng/g feces were common; with this rising tõ 1000 ng/g feces in some females by the start of the final third of gestation. That all our females carried to term despite high levels of fGC, in conjunction with known reduced sensitivity of maternal HPA axis to stressors toward parturition in other species (Brunton et al, 2008;Douglas et al, 2003;Johnstone et al, 2000), suggests that further work is required to test the link between adrenal activity and abortions.…”
Section: Discussionmentioning
confidence: 95%
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“…Even during the first week of late pregnancy, fGC levels already averaged~200 ng/g feces and levels of up to~400 ng/g feces were common; with this rising tõ 1000 ng/g feces in some females by the start of the final third of gestation. That all our females carried to term despite high levels of fGC, in conjunction with known reduced sensitivity of maternal HPA axis to stressors toward parturition in other species (Brunton et al, 2008;Douglas et al, 2003;Johnstone et al, 2000), suggests that further work is required to test the link between adrenal activity and abortions.…”
Section: Discussionmentioning
confidence: 95%
“…First, during gestation, GCs can arise from both maternal and feto-placental sources, with the relative contribution by the latter increasing as pregnancy proceeds (deM Fencl et al, 1980;Keller-Wood and Wood, 2001;Ilias, 2000, 2003;Waddell, 1993). However, it is not unusual for the fetoplacental unit to have little impact on maternal GCs levels, as is the case in rodents (Brunton et al, 2008). If feto-placental sources of GCs contribute significantly to maternal fGC levels in meerkats, we would expect fGC to peak at parturition.…”
Section: Discussionmentioning
confidence: 99%
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“…Por otra parte, la expresión placentaria de 11-beta hidroxiesteroide deshidrogenasa tipo 2, limita la exposición fetal a los glucocorticoides maternos a través de la metabolización de corticosterona en 11-dehidrocorticosterona, un metabolito inactivo 32 . Si bien la exposición reiterada a estrés en el embarazo reduce significativamente la actividad de esta enzima en la barrera placentaria y su expresión génica 33,34 , debe considerarse también que las respuestas del eje HHA materno en situaciones estresantes se reducen drásticamente al final del embarazo, lo que supone minimizar la transmisión de glucocorticoides hacia el feto 34 .…”
Section: Estrés Y Glucocorticoidesunclassified
“…There is a complex set of interactions between the hypothalamus, the pituitary and the adrenal glands (HPA axis). CRH is released from the hypothalamus and travels to the anterior pituitary to orchestrate an integrated stress response (Brunton, Russell, & Douglas, 2008: Grammatopoulos, 2008. It stimulates the release of beta-endorphin and adrenocorticotropin hormone (ACTH).…”
Section: The Role Of Corticotrophin Releasing Hormonementioning
confidence: 99%