Adaptive Optiken – Möglichkeiten für die Diagnostik hereditärer Netzhauterkrankungen

Abstract

The use of adaptive optics in ophthalmoscopy is a breakthrough technological achievement. With AO ophthalmoscopes, the microscopic retinal structure can be visualised non-invasively and on a cellular level, allowing for cellular scale imaging of the retinal nerve fibre layer, the smallest retinal capillaries, rod and cone photoreceptors, and the retinal pigment epithelium mosaic in the living subject. Regarding the diagnostic evaluation of retinal diseases, the current research focuses on monogenetic retinal diseases, which - when better understood - may allow for conclusions to be drawn about other multifactorial diseases and their underlying mechanisms (model disease). For disease monitoring and current and future pharmacological intervention (e.g. gene therapy), they will help to better establish novel and reliable clinical endpoints. New AO imaging devices have just become commercially available, and the number of retinal pathologies visualised with AO is increasing. Recently, an AO-based microstimulation technique has been introduced, which offers the possibility to directly correlate retinal structure with visual function on a cellular level.

Comparison of Green Versus Blue Fundus Autofluorescence inABCA4-Related Retinopathy

“… 58 Still, future studies on innovative technics such as swept-source OCT devices or adaptive optics are of interest and merit further investigations. 59 , 60 Small study cohorts are common as ABCA4 -related retinopathy ranks among the rare retinal diseases. Nevertheless, this is the overall largest study to provide a systematic investigation of the interreader and intermodality agreement for semiautomated grading of RPE atrophy using GAF and BAF imaging to date.…”

Multimodal imaging and deep learning in geographic atrophy secondary to age‐related macular degeneration

“…Commercial adaptive optics (AO) imaging devices allow for resolving the cone mosaic in healthy eyes (Domdei et al., 2017; Reiniger et al., 2017). In eyes with AMD, drusen and the altered outer retinal structure can impair the resolution.…”

Adaptive Optics for Photoreceptor-Targeted Psychophysics

“…With AO imaging, it is apparent that many retinal diseases exhibit structural changes of the photoreceptor mosaic involving cell loss or disruption, often only discernible at the microscopic level. That cell-resolved imaging may be a tool for early detection of latent disease onset holds considerable promise for vision health, and future therapeutic approaches may be identified efficiently with photoreceptor based imaging biomarkers [93,94].…”