Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina

Zhang, Yan; Rha, Jungtae; Jonnal, Ravi S.; Miller, Donald T.

doi:10.1364/opex.13.004792

Cited by 262 publications

(158 citation statements)

References 21 publications

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“…A simple 1-D FFT (after λ → k interpolation, k is wavenumber) along the spectral dimension of the data yields an X-Z cross-sectional image. [94][95][96][97][98][99] Zuluaga and Kortum were among the first to demonstrate a working LF FD OCT system using a technical sample. 94 Grajciar et al developed the first LF FD OCT system (shown in Fig.…”

Section: Line-field Octmentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

419

264

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Abstract. In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Line-field Octmentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

419

264

View full text Add to dashboard Cite

show abstract

“…One of the most promising applications of AO systems in ophthalmology is optical coherence tomography (OCT) which provides depth resolution, allowing clinicians to visualize different retinal layers (Zhang et al 2005). Moreover, when incorporated into a scanning laser ophthalmoscope (SLO), AO systems have significantly improved the lateral resolution of this type of ophthalmoscopy (Zhang et al 2006).…”

Section: Modeling Of a Mfdm For Retinal Imaging 181mentioning

confidence: 99%

Modeling of a Magnetic-Fluid Deformable Mirror for Retinal Imaging Adaptive Optics Systems

Iqbal

Amara

2007

International Journal of Optomechatronics

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Magnetic-fluid deformable mirrors (MFDMs) offer a simple alternative to the costly yet inefficient wavefront correctors currently in use in adaptive optics (AO) systems. They have been found particularly suitable for AO systems used in ophthalmic applications, such as retinal imaging. However, their practical implementation in clinical devices is contingent on the development of effective methods to model and control their surface-shape. This article presents a model of the dynamic response of the surface of a MFDM to the applied magnetic field. The resulting model allows the development of high-performance shape control algorithms for the mirror surface.

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“…Both of these groups used adaptive optics technology with a Hartmann-Shack wavefront sensor and a deformable mirror operating in a closed loop. Miller et al [8] have recently described the use of AO line-illumination parallel Fourier Domain OCT allowing photoreceptor imagining on single B-scans. Improvements in transverse resolution sufficient to image the photoreceptor mosaic have also been realized with adaptive optics in flood-illumination imaging and the scanning laser ophthalmoscope [9][10], but axial resolution is lower than that expected from OCT.…”

Section: Introductionmentioning

confidence: 99%