A novel three-dimensional fault-tolerant control guidance law is proposed for interception of maneuvering targets in the presence of external disturbances, actuator failures, and control input constraints. The input-to-state stability (ISS) method is introduced to design the fault-tolerant control guidance law to guarantee robust tracking of a maneuvering target. Then, a saturated fault-tolerant control guidance law is constructed using a modified saturation function to ensure the resulting control signal will never incur input constraints, and the convergence to a small neighborhood of origin is ensured in theory. Simulation results show that the presented approach is effective in achieving a successful interception against target maneuvers, external disturbances, actuator failures, and control input constraints.