1992
DOI: 10.1001/archderm.128.1.119
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Acyclovir in the prevention of severe aphthous ulcers

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Cited by 10 publications
(4 citation statements)
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“…Although acyclovir (400 mg twice a day for 1 year) is ineffective for RAS (28), high doses of antiviral treatment did appear to produce some improvement and a preventive effect in one study (29). Further investigation regarding the possibility of a contributing viral etiology and the pathogenesis of RAS should be conducted.…”
Section: Predisposing Factorsmentioning
confidence: 94%
“…Although acyclovir (400 mg twice a day for 1 year) is ineffective for RAS (28), high doses of antiviral treatment did appear to produce some improvement and a preventive effect in one study (29). Further investigation regarding the possibility of a contributing viral etiology and the pathogenesis of RAS should be conducted.…”
Section: Predisposing Factorsmentioning
confidence: 94%
“…Furthermore VZV‐DNA can be detected in lesional tissue by PCR (Pedersen et al , 1993), but contamination is possible and may underlie these observations (Pedersen et al , 1993). The evidence on the potential therapeutic benefits of aciclovir also requires further investigation (Wormser et al , 1988; Pedersen, 1992).…”
Section: Microbial Aspects Of Rasmentioning
confidence: 99%
“…Topical tetracyclines used alone or in combination with amphotericin can reduce the severity of ulceration, but do not alter the recurrence rate of RAS (Guggenheimer et al, 1968;Graykowski and Kingman, 1978;Denman and Schiff, 1979;Hayrinen-Immonen et al, 1994). The evidence on the therapeutic benefits of acyclovir requires further investigation (Wormser et al, 1988;Pedersen, 1992).…”
Section: Management (A) Diagnosismentioning
confidence: 99%