Acyclovir-containing liposomes for potential ocular delivery

Role of hydroxypropyl-β-cyclodextrin on freeze-dried and gamma-irradiated PLGA and PLGA–PEG diblock copolymer nanospheres for ophthalmic flurbiprofen delivery

“…This might be related to the slower diffusion of drug from NSs as can be observed from the results obtained in the in vitro release study giving a more sustained release of the drug from the colloidal systems, due to the complex formation between nonentrapped FB and the HPβCD. 55,56 The results suggest two mechanisms of penetration of the corneal membrane: NSs containing the entrapped drug penetrate the first layers of the corneal epithelium as demonstrated in the images obtained by CLSM. However, free FB not entrapped into the polymeric network forms a complex with HPβCD.…”

Cytotoxicity and potential antiviral evaluation of violacein produced by Chromobacterium violaceum

“…One strategy used to improve biological activity is the incorporation of active substances into liposomes which offer a substancial improvement in the therapeutic indices of the molecules entrapped in them (Gulati et al 1998). Some antiviral drugs and their liposomal formulations have been subjected to in vitro and in vivo studies and have been shown to result in an increase of drug absorption, less toxicity than conventional drug formulations and a more prolonged effect (Law et al 2000, Wutzler et al 2002. In this way, violacein-containing liposomes have been prepared and preliminary results show that its antiviral activity against HSV-1 is increased (data not shown).…”

Solid lipid nanoparticles for ocular drug delivery

“…The liposomes were formulated in the form of modified eye drops and the authors hope that this system can replace currently used invasive delivery routes in the treatment of major ocular conditions such as age-related macular degeneration, diabetic macular edema, and endophthalmitis. Others have reported that acyclovir containing liposomes are more effective than simple eye drop preparations, due to better penetration and absorption through the cornea (Law et al, 2000).…”